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Guan Xiu-Hao Xu Tian-Hua Chen Xi Mu Qi-Shuang Suo Jing-Fei Xu Rui-Xue Chen John Xiao Ting Xing-Hua Gao Chen Hong-Duo 《Lasers in medical science》2021,36(8):1619-1623
Lasers in Medical Science - This study is to determine the role of the fractional CO2 laser in topical drug delivery and the impact of local immune responses. Experimental rabbit nails were treated... 相似文献
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Lei Ma Hai-Bo Xue Xiu-Hao Guan Chun-Mei Shu Yu-Jie Zhang Jun-Hua Zhang Rong-Zhen An 《Brazilian journal of medical and biological research》2013,46(5):460-464
Melanocyte loss in vitiligo vulgaris is believed to be an autoimmune process.
Macrophage migration inhibitory factor (MIF) is involved in many autoimmune skin
diseases. We determined the possible role of MIF in the pathogenesis of vitiligo
vulgaris, and describe the relationship between MIF expressions and disease
severity and activity. Serum MIF concentrations and mRNA levels in PBMCs were
measured in 44 vitiligo vulgaris patients and 32 normal controls, using ELISA
and real-time RT-PCR. Skin biopsies from 15 patients and 6 controls were
analyzed by real-time RT-PCR. Values are reported as median (25th-75th
percentile). Serum MIF concentrations were significantly increased in patients
[35.81 (10.98-43.66) ng/mL] compared to controls [7.69
(6.01-9.03) ng/mL]. MIF mRNA levels were significantly higher in PBMCs from
patients [7.17 (3.59-8.87)] than controls [1.67
(1.23-2.42)]. There was also a significant difference in MIF mRNA levels in
PBMCs between progressive and stable patients [7.86 (5.85-9.13)
vs 4.33 (2.23-8.39)] and in serum MIF concentrations
[40.47 (27.71-46.79) vs 26.80 (10.55-36.07) ng/mL].
In addition, the vitiligo area severity index scores of patients correlated
positively with changes of both serum MIF concentrations (r = 0.488) and
MIF mRNA levels in PBMCs (r = 0.426). MIF mRNA levels were significantly
higher in lesional than in normal skin [2.43 (2.13-7.59)
vs 1.18 (0.94-1.83)] and in patients in the
progressive stage than in the stable stage [7.52 (2.43-8.84)
vs 2.13 (1.98-2.64)]. These correlations suggest that
MIF participates in the pathogenesis of vitiligo vulgaris and may be useful as
an index of disease severity and activity. 相似文献
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