Cystatin C predicts renal function impairment after partial or radical tumor nephrectomy

International Urology and Nephrology - To test the value of preoperative and postoperative cystatin C (CysC) as a predictor on kidney function after partial (PN) or radical nephrectomy (RN) in...     

Computer-aided evaluation of preparations for CAD/CAM-fabricated all-ceramic crowns

Objective

The aim of this study was the evaluation of preparations from general dental practitioners for zirconia crowns and their correlation with clinical recommendations using a digital approach.

Material and method

Seventy-five datasets of left first upper molars (FDI 16) prepared for single zirconia crowns by general dental practitioners were analyzed using a computer-aided design software (LAVA^TM Design; 3M ESPE, Seefeld, Germany) and a 3D-inspection software (COMETinspect®plus version 4.5; Steinbichler Optotechnik, Neubeuern, Germany). Evaluated parameters were convergence angle, undercuts, interocclusal reduction, abutment height, and design of preparation margin.

Results

The mean convergence angle was determined to be 26.7°. The convergence angle in the mesiobuccal to distopalatal dimension was significantly the highest (31.7°), and the abutment height showed a mean value of 4.1 mm. Convergence angle and abutment height showed a negative correlation. Seventy-three percent of the evaluated locations revealed a margin design conforming to ceramic restorations. In over 30 % of the cases, the interocclusal reduction was insufficient. Generally, no preparation fulfilled all recommendations. Five (6.66 %) of the preparations fulfilled four criteria, 16 (21.33 %) preparations fulfilled three criteria, 31 (41.33 %) fulfilled two criteria, 17 (22.66 %) preparations fulfilled one criterion, and 6 (8 %) fulfilled no criterion.

Conclusions

Within the limitations of this study, most general dental practitioners seem to have difficulties fulfilling all clinical recommendations given for the preparation of zirconia crowns. The presented digital approach seems to be a useful method to evaluate the preparation geometry.

Clinical relevance

The correct preparation geometry represents an important prerequisite for the success of all-ceramic full crowns. As preparations clearly need to be improved, the approach presented could be the basis of a future tool to increase preparation quality in practice and education by direct objective feedback.     

Ultrasonic diagnosis of primary sarcoma of the gallbladder

Real-time B-mode ultrasonography was employed in the identification of a primary sarcoma of the gallbladder. The ultrasonic findings of the tumor were an echogenic mass obliterating the gallbladder lumen with a stone in the center of the mass.     

Direct assessment of adherence and drug interactions in patients with hypertensive crisis—A cross‐sectional study in the Emergency Department

Though drug adherence is supposed to be low in hypertensive crisis (HTN‐C), there are no data available from direct adherence assessments. The aim of the present study was to evaluate adherence to prescribed antihypertensives and potential interactions of concomitant drugs and foods with prescribed antihypertensives in patients with HTN‐C by a direct evaluation via biochemical urine analysis. In the present cross‐sectional study, 100 patients with HTN‐C, admitted to the emergency department (ED), were included. A biochemical urine analysis using gas chromatography‐tandem mass spectrometry was performed. Out of 100 patients, 86 received antihypertensives. Urine analyses could be evaluated unambiguously in 62 patients. In 15 of these 62 patients (24%), a nonadherence could be demonstrated, and in 21 patients (34%), a partial nonadherence could be demonstrated. Patients with nonadherence or partial nonadherence showed a longer hypertension history (15[5‐22] vs 10[3‐15] years, P = 0.04) were prescribed more general medication (number 7.1 ± 3.4 vs 3.4 ± 1.8; P < 0.01) as well as antihypertensive drugs (number 2.8 ± 1.1 vs 1.5 ± 0.7, P < 0.01). A potential BP‐raising trigger by medications or food interaction was frequently detectable, predominantly with nonsteroidal anti‐inflammatory drugs (NSAIDs; n = 38), glucocorticoids (n = 8), antidepressants (n = 10), and licorice (n = 10). Nonadherence and partial nonadherence to prescribed antihypertensives might play a crucial role for the occurrence of HTN‐C. However, further case‐controlled studies are needed to confirm the present findings. Ingestion of concurrent over‐the‐counter drugs such as NSAIDs but also prescribed drugs as well as aliments may lead to critical BP elevation. In order to prevent HTN‐C, the present findings emphasize the importance for clinicians to pay attention to the issue of adherence and co‐medication.     

Kidney protective effects of baroreflex activation therapy in patients with resistant hypertension

Baroreflex activation therapy (BAT) is approved for the treatment of resistant hypertension. In addition to blood pressure (BP) reduction, pilot studies suggested several organoprotective effects of BAT. Thirty‐two patients with resistant hypertension were prospectively treated with BAT. Besides office BP and 24‐hour ambulatory BP (ABP) measurements, detection of a urinary proteome‐based classifier (CKD273), which has been shown to predict chronic kidney disease (CKD) progression, was carried out at baseline and after 6 months of BAT. Office BP significantly decreased from 170 ± 25/90 ± 18 to 149 ± 29/82 ± 18 mm Hg. Analysis of CKD273 score and eGFR with CKD‐EPI equation at baseline revealed strong correlation (r = 0.568, P < 0.001). After 6 months of BAT, there was no significant change in CKD273 score (−0.061 [95% CI: −0.262 to 0.140], P = 0.601). However, by stratification of the data regarding ABP response, there was a statistically significant (P = 0.0113) reduction in the CKD273 score from a mean of 0.161 [95% CI: −0.093 to 0.414] to −0.346 [95% CI: −0.632 to −0.060] after BAT in patients with systolic ABP decrease of ≥5 mm Hg. These data emphasized potential nephroprotective effects of BAT in patients with sufficient BP response.     

Impact of medication adherence on the efficacy of Baroreflex activation therapy

Therapy adherence significantly determines the success of antihypertensive therapy, especially in patients with resistant hypertension. Our study investigates the impact of drug adherence on the efficacy of Baroreflex‐activation‐therapy (BAT). In this retrospective analysis, the authors measured blood pressure (BP) and antihypertensive medication adherence (by gas chromatography‐mass spectrometry [GC‐MS] urine analysis) before and 6 months after BAT initiation. Adherence was defined as detection of ≥80% intake of prescribed medication at the time of follow‐up. Response to BAT was defined as BP drop ≥5 mmHg in systolic 24 h‐ambulatory BP (ABP) after 6 months. Overall patients (n = 38) median medication adherence was low, but rose from 60% (IQR 25%–100%) to 75% (IQR 38%–100%; p = .0194). After 6 months of BAT, mean systolic and diastolic office BP (‐21 ± 25 mmHg and ‐9 ± 15 mmHg; p < .0001 and .0004) as well as 24 h‐ABP dropped significantly (‐9 ± 17 mmHg and ‐5 ± 12 mmHg; p = .0049 and .0280). After 6 months of BAT, 21 patients (60%) could be classified as responders. There was neither significant difference in mean office systolic (‐21 ± 23 mmHg vs. ‐21 ± 28 mmHg; p = .9581) nor in 24 h‐systolic ABP decrease (‐11 ± 19 mmHg vs. ‐7 ± 15 mmHg; p = .4450) comparing adherent and non‐adherent patients. Whereas Antihypertensive Therapeutic Index (ATI) was unchanged in non‐responders, it significantly decreased in responders (from 50 ± 16 to 46 ± 16; p = .0477). These data are the first to show that BAT‐initiation leads to a clear BP reduction independently of patients´ medication adherence. Response to BAT is associated with a significant lowering of ATI, which might contribute to an underestimation of BAT efficacy.     

Cytokine adsorption therapy in lymphoma-associated hemophagocytic lymphohistiocytosis and allogeneic stem cell transplantation

Journal of Artificial Organs - Lymphoma-associated Hemophagocytic lymphohistiocytosis (HLH) represents a severe complication of disease progression, mediated through cytokine release from the...