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KARL-ANTON KREUZER JU¨RGEN KURT ROCKSTROH WOLFGANG JELKMANN ALBERT THEISEN ULRICH SPENGLER & TILMANN SAUERBRUCH 《British journal of haematology》1997,96(2):235-239
Severe anaemia is a frequent complication in advanced HIV infection. In our study we investigated the interaction between cytokine network, HIV infection and erythropoietin (Epo) response with increasing anaemia levels. No correlations could be established between circulating tumour necrosis factor (TNF)-alpha and any of the examined parameters. However, a negative correlation was found between haemoglobin values and soluble TNF receptor levels (sTNF-R-I: r = −0.54; P < 0.001; sTNF-R II: r = −0.47; P < 0.001) as well as interleukin-6 levels ( r = −0.29; P < 0.001). In contrast, no significant increase in log[Epo], counterbalancing haemoglobin decline and paralleling the rise in sTNF receptors, was found. In patients classified as stage III, according to the Centers for Disease Control (CDC) classification, the erythropoietin response was significantly more impaired than in patients from CDC groups I and II ( P < 0.001). The results of this study suggest that similar to its action in vitro , activation of the TNF/TNF-R system may impair erythropoietin production in HIV-associated anaemia. Due to the brief half-life of TNF-α, this activation is particularly reflected by elevations of soluble TNF receptor levels. 相似文献
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BUSCHMANN JOCHEN; KOCH WOLFGANG; FUHST RAINER; HEINRICH UWE 《Toxicological sciences》1996,32(1):96-101
One of the uses of MDI is as an alternative to formaldehydein the manufacture of furniture, its main route of exposureto humans being by inhalation. There have been no previous studieson the potential prenatal toxic effects of this compound. Toclose this gap in information, gravid Wistar rats, Crl:(WI)BR,were exposed by whole-body inhalation to clean air (control)and to 1, 3, and 9 mg/m3 MDI, respectively, for 6 hr per dayfrom Days 6 to 15 post conception (p.c). Rats were killed onDay 20 p.c. and the following results were obtained: Treatmentcaused a dose-dependent decrease in food consumption in allsubstance-treated groups during exposure, returning to normalvalues after cessation of treatment. The lung weights in thehigh-dose group were significantly increased compared to thesham-treated control animals. Treatment did not influence anyother maternal and/or fetal parameters investigated (maternalweight gain, number of corpora lutea, implantation sites, preand postimplantation loss, fetal and placental weights, grossand visceral anomalies, degree of ossification), although aslight but significant increase in litters with fetuses displayingasymmetric sternebra(e) was observed after treatment with thehighest dose of 9 mg/m3. Although the relevance of an increaseof this minor anomaly in doses which cause toxic effects indams (reduced food consumption, increased lung weights) is limitedand the number observed is within the limits of biological variability,a substance-induced effect in the high-dose group cannot beexcluded with certainty. Consequently, a no embryotoxic effectlevel of 3 mg/m3 was determined. 相似文献
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Sexual attraction of male gametes toward females of many brownalgae species is induced by diffusible pheromones, which leadto a chemotactic modification of the loop-like 2-dimensionalswimming paths of the males. We propose a stochastic model andanalyse a suitable diffusion approximation in order to calculatequantities as the aggregation factor, the rotational flux component,and the mean mating time. 相似文献
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Exercise Induced Sympathetic Influences Do Not Change Interatrial Conduction Times in VDD and DDD Pacing 总被引:1,自引:0,他引:1
BRUNO ISMER GEORG H. VON KNORRE WOLFGANG VOSS WERNER GRILLE GEORG KLENKE KAMESH PULYA WALTER KOGLEK ANTON SUNTINGER HEIDRON LUESSOW 《Pacing and clinical electrophysiology : PACE》1996,19(11):1786-1790
Using telemetry, right atrial electrogram (RA), and marker channel of atrial sense events (MA ) in combination with the left atrial electrogram (LA), recorded by a filtered bipolar esophageal lead, interatrial conduction during submaximal exercise and at rest was examined in 46 DDD pacemaker patients. The RA-LA and MA -LA conduction times measured in the presence of atrial sensing (VDD) as well as the conduction time SA -LA from atrial stimulus (SA ) to LA, determined during atrial pacing (DDD) were found to be individual constants independent of exercise induced sympathetic influences. Thus, having determined an optima! mechanical interval (LA-LV)mech/opt from left atrium to ventricle by other methods, the optimal AV delay for DDD as well as for VDD operation can be calculated by the sum of the appropriate interatrial conduction time (SA -LA, respectively MA -LA) and the (LA-LV)mech/opt interval. Due to the constant SA -LA and MA -LA, the difference between these two values (AV delay correction interval) is a constant as well, which remains unchanged during exercise. Therefore, in selecting the rate responsive AV delay, only hemodynamic and not electrophysiologica] measurements need to be considered. 相似文献
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ALI ERDOGAN M.D. NORBERT GUETTLER M.D. OLIVER DOERR WOLFGANG FRANZEN M.D. NEDIM SOYDAN M.D. MEHMET BILGIN M.D. PASCAL VOGELSANG MARIANA PARAHULEVA M.D. HARALD TILLMANNS M.D. SIEGBERT STRACKE M.D. DURSUN GUENDUEZ M.D. CHRISTIANE NEUHOF M.D. 《Journal of cardiovascular electrophysiology》2010,21(10):1109-1113
Comparison of Radiofrequency Versus Conventional Catheter Ablation. Introduction: Radiofrequency (RF) catheter ablation has been established as an effective and curative treatment for atrial flutter (AFL). Approved methods include a drag‐and‐drop method, as well as a point‐by‐point ablation technique. The aim of this study was to compare the acute efficacy and procedural efficiency of a multipolar linear ablation catheter with simultaneous energy delivery to multiple catheter electrodes against conventional RF for treatment of AFL. Methods: Patients presenting to our department with symptomatic, typical AFL were enrolled consecutively and randomized to conventional RF ablation with an 8‐mm tip catheter (ConvRF) or a duty‐cycled, bipolar‐unipolar RF generator delivering power to a hexapolar tip‐versatile ablation catheter (T‐VAC) group. For both groups, the procedural endpoint was bidirectional cavotricuspid isthmus block. Results: Sixty patients were enrolled, 30 patients each assigned to ConvRF and T‐VAC groups. Total procedure time (40.2 ± 15.8 min vs 60.5 ± 12.7 min), energy delivery time (8.5 ± 3.7 min vs 14.7 ± 5.2 min), radiation dose (14.5 ± 3.5 cGy/cm2 vs 31.7 ± 12.1 cGy/cm2), and the minimum number of RF applications needed to achieve block (4.2 ± 2.4 vs 8.9 ± 7.2) were significantly lower in the T‐VAC group. In 7 patients treated with the T‐VAC catheter, bidirectional block was achieved with less than 3 RF applications, versus no patients with conventional RF energy delivery. Conclusion: The treatment of typical AFL using a hexapolar catheter with a multipolar, duty‐cycled, bipolar‐unipolar RF generator offers comparable effectiveness relative to conventional RF while providing improved procedural efficiency. (J Cardiovasc Electrophysiol, Vol. 21, pp. 1109‐1113) 相似文献
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Compartments of the adult parasellar region 总被引:1,自引:0,他引:1