全文获取类型
收费全文 | 3201篇 |
免费 | 179篇 |
国内免费 | 12篇 |
专业分类
耳鼻咽喉 | 63篇 |
儿科学 | 171篇 |
妇产科学 | 37篇 |
基础医学 | 327篇 |
口腔科学 | 58篇 |
临床医学 | 156篇 |
内科学 | 795篇 |
皮肤病学 | 121篇 |
神经病学 | 117篇 |
特种医学 | 158篇 |
外科学 | 529篇 |
综合类 | 78篇 |
一般理论 | 1篇 |
预防医学 | 97篇 |
眼科学 | 129篇 |
药学 | 267篇 |
中国医学 | 22篇 |
肿瘤学 | 266篇 |
出版年
2023年 | 29篇 |
2022年 | 56篇 |
2021年 | 126篇 |
2020年 | 95篇 |
2019年 | 103篇 |
2018年 | 137篇 |
2017年 | 99篇 |
2016年 | 131篇 |
2015年 | 133篇 |
2014年 | 171篇 |
2013年 | 198篇 |
2012年 | 311篇 |
2011年 | 298篇 |
2010年 | 140篇 |
2009年 | 129篇 |
2008年 | 190篇 |
2007年 | 179篇 |
2006年 | 152篇 |
2005年 | 153篇 |
2004年 | 124篇 |
2003年 | 111篇 |
2002年 | 78篇 |
2001年 | 17篇 |
2000年 | 19篇 |
1999年 | 21篇 |
1998年 | 15篇 |
1997年 | 11篇 |
1996年 | 10篇 |
1995年 | 9篇 |
1994年 | 14篇 |
1993年 | 6篇 |
1992年 | 14篇 |
1991年 | 14篇 |
1990年 | 12篇 |
1989年 | 15篇 |
1988年 | 9篇 |
1987年 | 10篇 |
1986年 | 6篇 |
1985年 | 3篇 |
1984年 | 4篇 |
1979年 | 3篇 |
1976年 | 5篇 |
1975年 | 4篇 |
1974年 | 3篇 |
1972年 | 3篇 |
1971年 | 2篇 |
1970年 | 2篇 |
1969年 | 3篇 |
1968年 | 2篇 |
1903年 | 2篇 |
排序方式: 共有3392条查询结果,搜索用时 15 毫秒
1.
Koel Dutt P N Agarwal Rajdeep Singh Vikas Singh Tomar 《The Indian journal of surgery》2015,77(1):62-64
Haemophilia is a common cause of genetically inherited bleeding disorders. Pseudotumours occur in 1–2 % of persons with severe forms of haemophilia. These are a result of repeated haemorrhage into soft tissues, subperiosteum or a site of bone fracture with inadequate resorption of the extravasated blood. There are a number of therapeutic alternatives for this dangerous condition: surgical removal, percutaneous management, irradiation, embolization etc. In this case report, we describe the natural history, clinical course and successful surgical management of a patient with haemophilia who presented with a massive pseudotumour. We also briefly review the relevant literature on the various therapeutic modalities that have been implemented in the management of this rare complication. Though surgeons may be averse to operate on haemophiliacs, primary surgical management as done in our case may prove to be the definitive treatment option for such patients. 相似文献
2.
3.
Anti-rheumatic therapy has been targeted against the symptoms arising from chronic inflammation of the joint. This has resulted in the extensive use of non-steroidal anti-inflammatory drugs. It is now becoming apparent that these agents have no beneficial effect on disease progression. This mini review concentrates on the formation and maintenance of pannus, the granulomatous tissue responsible for cartilage and bone erosion. This reveals a number of possible therapeutic targets. Protease inhibitors could be used to interfere with the degradatory processes. The diverse functions of endothelial cells suggest oedema formation, cell accumulation and supply of nutrients to the granulomatous tissue could all be targeted by appropriate therapy. Alternatively the immune processes that control pannus formation and state of activation could be regulated by interfering with antigen presentation and the cytokine network. 相似文献
4.
Lidong Zhang James E Littlejohn Yu Cui Xiaobo Cao Chander Peddaboina W Roy Smythe 《Molecular cancer》2010,9(1):110
Background
Bortezomib, a proteasome-specific inhibitor, has emerged as a promising cancer therapeutic agent. However, development of resistance to bortezomib may pose a challenge to effective anticancer therapy. Therefore, characterization of cellular mechanisms involved in bortezomib resistance and development of effective strategies to overcome this resistance represent important steps in the advancement of bortezomib-mediated cancer therapy. 相似文献5.
6.
Madhuri Dadwal Chander Mohan D. R. Sharma 《Indian journal of otolaryngology and head and neck surgery》2007,59(3):261-263
Secondary tuberculosis of pharynx is a rare condition as pharynx is not a common site for clinically manifest tuberculosis.
A rare and unusual case of secondary oropharyngeal tuberculosis in a 40 years male patient, who presented with an ulceroproliferative
lesion of oropharynx extending to nasopharynx and laryngopharynx is being reported. 相似文献
7.
This work presents the first sodium MRI functional renal study on a mouse model. The tissue sodium concentration was monitored during induced diuresis with furosemide. By using density-weighted chemical shift imaging (DWCSI) at high field strength a temporal resolution of less than 5 min for three dimensional (3D) data sets with high spatial resolution was achieved. A maximum increase of 20% in the cortex and a decrease of 45% of the original signal strength in the medulla were observed. These findings correspond well with experiments conducted on much larger rodent models. 相似文献
8.
Candidaemia: a 10-year study in an Indian teaching hospital 总被引:3,自引:0,他引:3
Retrospective evaluation of candidaemia patients was performed in an Indian teaching hospital over a 10-year period. The incidence of patients with candidaemia increased eleven-fold in the second half of the study period (55 patients) compared with the first half (5 patients). Haematological malignancies (11 patients), neonatal septicaemia (9), cardiac abnormalities and cardiac surgery (9) were the commonest underlying diseases in these patients. Candida albicans (50%), C. guilliermondii (17%), C. tropicalis (15%) and C. parapsilosis (8%) were the most common fungal pathogens isolated from blood culture. Therapy with two or more antibiotics (92%), corticosteroid administration (25%), intravascular catheter use for over 24 h (78%) and neutropenia (48%) were the accountable predisposing factors. Prolonged hospitalization (mean average 22.2 days as compared with 11.2 days in other patients) was an added risk factor in these patients. 相似文献
9.
Kevil CG Hicks MJ He X Zhang J Ballantyne CM Raman C Schoeb TR Bullard DC 《The American journal of pathology》2004,165(2):609-616
Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by immune complex-mediated tissue injury. Many different adhesion molecules are thought to participate in the development of SLE; however, few studies have directly examined the contributions of these proteins. Here we demonstrate that LFA-1 plays an essential role in the development of lupus in MRL/MpJ-Fas(lpr) mice. Mice deficient in LFA-1, but not Mac-1, showed significantly increased survival, decreased anti-DNA autoantibody formation, and reduced glomerulonephritis. The phenotype of the LFA-1-deficient mice was similar to that observed in beta(2) integrin-deficient (CD18-null) MRL/MpJ-Fas(lpr) mice, suggesting a lack of redundancy among the beta(2) integrin family members and other adhesion molecules. These studies identify LFA-1 as a key contributor in the pathogenesis of autoimmune disease in this model, and further suggest that therapeutic strategies targeting this adhesion molecule may be beneficial for the treatment of SLE. 相似文献
10.
Prabhakar V Grinstaff MW Alarcon J Knors C Solan AK Niklason LE 《Journal of biomedical materials research. Part A》2003,67(1):303-311
Techniques have been developed to culture bovine or porcine vascular cells on polyglycolic acid (PGA) scaffolds to form engineered vessels. Previously, it was shown that smooth muscle cells (SMCs) that were in close proximity to PGA remnants after 8 weeks of culture had lower expression of SMC markers of differentiation and were more mitotic compared with SMCs that were distant from polymer residuals. Modifications of PGA were explored as a means to minimize residual polymer fragments after culture. To hasten degradation, polymer was treated with heat, NaOH, or gamma-irradiation. Differential scanning calorimetry, mass and tensile strength degradation, and inherent viscosity were used to assess polymer characteristics. When polymer was maintained in aqueous conditions, tensile strength of treated PGA degraded to zero within 3 weeks for each treatment. Engineered vessel constructs cultured on NaOH and gamma-treated polymer displayed smooth muscle alpha-actin throughout the vessel wall. Scaffold treatment impacted graft morphology, cellular differentiation, and mechanical integrity. 相似文献