全文获取类型
收费全文 | 2358篇 |
免费 | 130篇 |
国内免费 | 5篇 |
专业分类
耳鼻咽喉 | 18篇 |
儿科学 | 52篇 |
妇产科学 | 218篇 |
基础医学 | 289篇 |
口腔科学 | 34篇 |
临床医学 | 154篇 |
内科学 | 534篇 |
皮肤病学 | 43篇 |
神经病学 | 100篇 |
特种医学 | 42篇 |
外科学 | 227篇 |
综合类 | 93篇 |
一般理论 | 3篇 |
预防医学 | 109篇 |
眼科学 | 200篇 |
药学 | 213篇 |
中国医学 | 10篇 |
肿瘤学 | 154篇 |
出版年
2024年 | 3篇 |
2023年 | 10篇 |
2022年 | 40篇 |
2021年 | 85篇 |
2020年 | 45篇 |
2019年 | 51篇 |
2018年 | 71篇 |
2017年 | 43篇 |
2016年 | 56篇 |
2015年 | 64篇 |
2014年 | 80篇 |
2013年 | 88篇 |
2012年 | 203篇 |
2011年 | 200篇 |
2010年 | 93篇 |
2009年 | 59篇 |
2008年 | 133篇 |
2007年 | 142篇 |
2006年 | 147篇 |
2005年 | 135篇 |
2004年 | 117篇 |
2003年 | 106篇 |
2002年 | 73篇 |
2001年 | 48篇 |
2000年 | 65篇 |
1999年 | 46篇 |
1998年 | 20篇 |
1997年 | 23篇 |
1996年 | 17篇 |
1995年 | 14篇 |
1994年 | 9篇 |
1993年 | 19篇 |
1992年 | 21篇 |
1991年 | 18篇 |
1990年 | 20篇 |
1989年 | 24篇 |
1988年 | 19篇 |
1987年 | 9篇 |
1986年 | 17篇 |
1985年 | 8篇 |
1984年 | 10篇 |
1983年 | 4篇 |
1981年 | 5篇 |
1979年 | 4篇 |
1978年 | 3篇 |
1977年 | 5篇 |
1970年 | 4篇 |
1969年 | 4篇 |
1968年 | 2篇 |
1967年 | 3篇 |
排序方式: 共有2493条查询结果,搜索用时 15 毫秒
1.
Allergic autoimmune reaction after exposure to heavy metals such as mercury may play a causal role in autism, a developmental disorder of the central nervous system. As metallothionein (MT) is the primary metal-detoxifying protein in the body, we conducted a study of the MT protein and antibodies to metallothionein (anti-MT) in normal and autistic children whose exposure to mercury was only from thimerosal-containing vaccines. Laboratory analysis by immunoassays revealed that the serum level of MT did not significantly differ between normal and autistic children. Furthermore, autistic children harboured normal levels of anti-MT, including antibodies to isoform MT-I (anti-MT-I) and MT-II (anti-MT-II), without any significant difference between normal and autistic children. Our findings indicate that because autistic children have a normal profile of MT and anti-MT, the mercury-induced autoimmunity to MT may not be implicated in the pathogenesis of autism. 相似文献
2.
Modulation of cytokine production from an EpiOcular corneal cell culture model in response to Staphylococcus aureus superantigen 总被引:3,自引:0,他引:3
A Thakur PhD A Clegg MSc A Chauhan MSc MDP Willcox PhD 《Clinical & experimental ophthalmology》1997,25(4):43-45
The present study investigated the hypothesis that Staphylococcus aureus enterotoxin B (SEE) produces epithelial cell death and releases inflammatory cytokines that produce stromal infiltration during contact lens induced peripheral ulceration. Epithelial cells were incubated with different doses of SEB for various time periods. Culture supernatants were assayed for cytokines IL- lo, IL-6 and chemotactic agents IL-8 and LTB,. SEE induced the production of IL- I p and IL-8. Epithelial cells exposed for longer periods (48 h) with low concentrations of SEB produced significantly higher levels (N0.02) of IL-Ip and IL-8 (P<0.05) compared t o a 24 h exposure. SEB did not induce the production o f IL-6 and 相似文献
3.
B A Barut L I Zon M K Cochran S R Paul D Chauhan A Mohrbacher J Fingeroth K C Anderson 《Leukemia research》1992,16(10):951-959
The role of interleukin 6 (IL-6) in the growth of five multiple myeloma-derived cell lines was characterized. The U266 and RPMI 8226 cell lines demonstrated increased DNA synthesis when cultured with exogenous IL-6, expressed IL-6 cell surface receptors (IL-6Rs) and expressed mRNA for IL-6R. However, these cells did not secrete detectable IL-6 protein, and a neutralizing antibody to IL-6 did not inhibit their growth. Three other myeloma-derived cell lines ARH-77, IM-9 and HS-Sultan did not respond to exogenous IL-6, secrete IL-6 or express cell surface IL-6Rs. The IL-6 responsive cell lines bore late B-cell surface antigens (Ags), CD38 and PCA-1, whereas those lines which were non-IL-6 responsive strongly expressed B1 (CD20) and B4 (CD19) Ags, representing earlier stages in B-cell differentiation. Finally, the two IL-6 responsive cell lines did not express Epstein-Barr virus (EBV) proteins; in contrast, EBV encoded proteins typically expressed during latency could be detected in the three non-IL-6 responsive lines, confirming infection with virus. These studies clarify the heterogeneity observed in the myeloma cell line phenotype and biology and suggest that the U266 and RPMI 8226 cell lines, which express IL-6 cell surface receptors and are IL-6 responsive, may be useful for further study of IL-6 signal transduction in and related IL-6 mediated growth of myeloma in vivo. In contrast, those cell lines which are IL-6-independent provide a model for further study of EBV transformation and IL-6-dependent growth mechanisms in malignancy. 相似文献
4.
5.
Balwantray C. Chauhan Stephen M. Drance Calvin Lai 《Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie》1989,227(3):216-220
Cluster analysis in perimetry is a technique used in the evaluation of localised visual field loss. It has previously been applied to suprathreshold data and, unlike the indices currently available to indicate localised loss, it is influenced by the relative positions of individual defects. This paper describes a cluster analysis for use with data from Program 31 of the Octopus perimeter. To demonstrate the technique, sensitivity values of normal 60-year-old subject were altered to simulate localised loss. Illustrative examples of clinical cases are given, showing differing degrees of localised loss that do not influence the corrected loss variance (CLV) but influence the computed cluster parameters. It is hoped that the value of this form of analysis will be demonstrated in clinical follow-up of glaucoma patients. 相似文献
6.
R Kashyap A Babbar I Sahai R Prakash N L Soni U P Chauhan 《Clinical nuclear medicine》1992,17(2):119-122
Combined Tc-99m MDP skeletal imaging and Tc-99m(V) DMSA whole body scans to detect metastases were performed during the follow-up of 30 patients who underwent surgery for breast carcinoma. Eight patients had normal Tc-99m MDP and Tc-99m(V) DMSA scans and were declared free of metastatic disease, further confirmed by no change in symptomatology over a 1-year follow-up period. Twenty-two patients had positive Tc-99m MDP scans with varied skeletal involvement. Tc-99m(V) DMSA scans showed matched areas of increased radiotracer concentration in bony metastases in 20 of these patients. Tc-99m(V) DMSA concentration was not seen in traumatic vertebral collapse or in coexistent osteoarthritic disease in vertebral metastatic involvement. Interestingly, Tc-99m(V) DMSA showed increased concentration in brain and liver metastases. Pentavalent Tc-99m(V) DMSA appears useful for detecting skeletal and soft-tissue metastases in breast carcinoma, and can improve the specificity of Tc-99m MDP bone scans in screening for bone metastases. 相似文献
7.
Deepu Banerji Rajesh Acharya Sanjay Behari Devendra K. Chhabra Dr. Vijendra K. Jain MCh 《Neurosurgical review》1997,20(1):25-31
The choice of a surgical approach for multi-level cervical spondylotic myelopathy (CSM) and ossification of the posterior longitudinal ligament (OPLL) is still a controversial issue. While most of the surgeons are still performing decompression by laminectomy some are doing multi-level anterior decompression. Few neurosurgeons are performing decompression by corpectomy. We have treated 26 patients by median cervical corpectomy during the last 4 years. These patients were followed up for a mean period of 25 months. Twenty one (80%) patients had a good outcome, 2 patients remained unchanged and 3 expired. Review of the literature and our experience indicates that patients with CSM and OPLL should be operated by median cervical corpectomy (anterior approach). 相似文献
8.
9.
10.