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Psychiatric morbidity among Punjabi medical patients in England measured by General Health Questionnaire 总被引:1,自引:0,他引:1
The 28-item GHQ was administered to 282 Punjabi and white British patients visiting two Health Centres in Bedford. We discovered that ethnicity is not significantly correlated with GHQ 'caseness', but that differences exist in somatic and depressive symptomatology. The discussion relates these findings to debates about the psychiatric morbidity of Asian immigrants and somatization. 相似文献
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Stainless steel wear debris of a scoliotic growth guidance system has little local and systemic effect in an animal model 下载免费PDF全文
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Melnyk AD Wen TL Kingwell S Chak JD Singh V Cripton PA Fisher CG Dvorak MF Oxland TR 《Spine》2012,37(18):E1126-E1133
STUDY DESIGN.: A biomechanical human cadaveric study. OBJECTIVE.: To determine the percentage of shear force supported by posterior lumbar spinal devices of varying stiffnesses under anterior shear loading in a degenerative spondylolisthesis model. SUMMARY OF BACKGROUND DATA.: Clinical studies have demonstrated beneficial results of posterior arthrodesis for the treatment of degenerative spinal conditions with instability. Novel spinal implants are designed to correct and maintain spinal alignment, share load with the spine, and minimize adjacent level stresses. The optimal stiffness of these spinal systems is unknown. To our knowledge, low-stiffness posterior instrumentation has not been tested under an anterior shear force, a highly relevant force to be neutralized in the clinical case of degenerative spondylolisthesis. METHODS.: The effects of implant stiffness and specimen condition on implant load and intervertebral motion were assessed in a biomechanical study. Fifteen human cadaveric lumbar functional spinal units were tested under a static 300 N axial compression force and a cyclic anterior shear force (5-250 N). Implants (high-stiffness [HSI]: ? 5.5-mm titanium, medium-stiffness [MSI]: ? 6.35 × 7.2-mm oblong PEEK, and low-stiffness [LSI]: ? 5.5-mm round PEEK) instrumented with strain gauges were used to calculate loads and were tested in each of 3 specimen conditions simulating degenerative changes: intact, facet instability, and disc instability. Intervertebral motions were measured with a motion capture system. RESULTS.: As predicted, implants supported a significantly greater shear force as the specimen was progressively destabilized. Mean implant loads as a percent of the applied shear force in order of increasing specimen destabilization for the HSI were 43%, 67%, and 76%; mean implant loads for the MSI were 32%, 56%, and 77%; and mean implant loads for the LSI were 18%, 35%, and 50%. Anterior translations increased with decreasing implant stiffness and increasing specimen destabilization. CONCLUSION.: Implant shear stiffness significantly affected the load sharing between the implant and the natural spine in anterior shear ex vivo. Low-stiffness implants transferred significantly greater loads to the spine. This study supports the importance of load-sharing behavior when designing new implants. 相似文献
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Ratha-korn Vilaichone ;Yoshio Yamaoka ;Seiji Shiota ;Thawee Ratanachu-ek ;Lotay Tshering ;Tomohisa Uchida ;Toshio Fujioka ;Varocha Mahachai 《World journal of gastroenterology : WJG》2013,19(33):5508-5512
AIM:To survey the antibiotic resistance pattern of Helicobacter pylori(H.pylori)strains isolated from Bhutanese population.METHODS:We isolated 111 H.pylori strains from the gastric mucosa of H.pylori-infected patients in Bhutan in 2010.The Epsilometer test was used to determine the minimum inhibitory concentrations(MICs)of amoxicillin(AMX),clarithromycin(CLR),metronidazole(MNZ),levofloxacin(LVX),ciprofloxacin(CIP),and tetracycline(TET).RESULTS:Nineteen of the isolated H.pylori strains were susceptible to all antibiotics tested.The isolated strains showed the highest rate of antibiotic resistance to MNZ(92/111,82.9%).Among the 92 MNZresistant strains,74 strains(80.4%)showed high-level resistance(MIC≥256 g/mL).Three strains were resistance to LVX(2.7%).These strains were also resistance to CIP.None of the strains showed resistance to CLR,AMX and TET.CONCLUSION:CLR-based triple therapy is a more effective treatment approach over MNZ-based triple therapy for H.pylori infection in Bhutan. 相似文献
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Wohlfahrtiimonas chitiniclastica has been identified as an emerging pathogen predominantly associated with cutaneous myiasis and poor hygiene. Traditional biochemical methods can be unreliable and misleading when identifying this organism, and modern molecular techniques are often necessary for high-confidence identification. There have been very few cases of human infection with W. chitiniclastica reported in the literature. We present two recent cases identified at the University of Kentucky Medical Center (a male with myiasis related to gangrene and an elderly female with a left-leg wound and myiasis), both of which were identified using matrix-assisted laser desorption ionization–time of flight mass spectrometry (MALDI-TOF MS) for identification, and describe the clinical and microbiologic characteristics associated with this microorganism. 相似文献
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Garey KW Ghantoji SS Shah DN Habib M Arora V Jiang ZD DuPont HL 《The Journal of antimicrobial chemotherapy》2011,66(12):2850-2855
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Tzimopoulou S Cunningham VJ Nichols TE Searle G Bird NP Mistry P Dixon IJ Hallett WA Whitcher B Brown AP Zvartau-Hind M Lotay N Lai RY Castiglia M Jeter B Matthews JC Chen K Bandy D Reiman EM Gold M Rabiner EA Matthews PM 《Journal of Alzheimer's disease : JAD》2010,22(4):1241-1256
Here we report the first multi-center clinical trial in Alzheimer's disease (AD) using fluorodeoxyglucose positron emission tomography ([18F]FDG-PET) measures of brain glucose metabolism as the primary outcome. We contrasted effects of 12 months treatment with the PPARγ agonist Rosiglitazone XR versus placebo in 80 mild to moderate AD patients. Secondary objectives included testing for reduction in the progression of brain atrophy and improvement in cognition. Active treatment was associated with a sustained but not statistically significant trend from the first month for higher mean values in Kiindex and CMRgluindex, novel quantitative indices related to the combined forward rate constant for [18F]FDG uptake and to the rate of cerebral glucose utilization, respectively. However, neither these nor another analytical approach recently validated using data from the Alzheimer's Disease Neuroimaging Initiative indicated that active treatment decreased the progression of decline in brain glucose metabolism. Rates of brain atrophy were similar between active and placebo groups and measures of cognition also did not suggest clear group differences. Our study demonstrates the feasibility of using [18F]FDG-PET as part of a multi-center therapeutics trial. It suggests that Rosiglitazone is associated with an early increase in whole brain glucose metabolism, but not with any biological or clinical evidence for slowing progression over a 1 year follow up in the symptomatic stages of AD. 相似文献