Correlations between the pharmacokinetics and dynamics of pharmacological effects of bromantane

It is shown that there is a mathematical correlation between an integral characteristic of activity of the organism (the capacity for work), electrophysiological indexes of functioning of the brain structures, and the concentration of a novel derivative of 2-aminoadamantane, bromantane, in the brain. The nature of the correlation between integral characteristics of the organism studied on different levels is found to change depending on the time elapsed from the administration of the preparation and on its concentration in the blood or target tissue. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 119, N ^o 3 pp. 305–308, March, 1995 Presented by M. D. Mashkovskii, Member of the Russian Academy of Medical Sciences     

Determination of subpopulations of T- and B-lymphocytes in human blood using an immunofluorescence method

The immunofluorescent technique for assaying T- and B-lymphocyte subpopulations, using monoclonal (OCT3, OCT4, OCT8) and monospecific antibodies is described. The results of immunocompetent cell determinations in normal subjects and in patients are presented. A conclusion is made that use of universal immunofluorescent method for assays of the lymphocyte subpopulations widens the possibilities of diagnosis of immunodeficiency states.     

The late examination results in children with pylorospasm and dyskinesia of the proximal sections of the small intestine]

The article analyses the late-term results of examination of 46 children with neurogenous dyskinesias of the gastrointestinal tract which were recognised in infancy for the first time. The author believes that the functional, motor-evacuation, and sphincter disorders of the proximal parts of the digestive tube lead to the development of organic noninfectious diseases of the gastroduodenal system.     

Synthesis and antihypoxic activity of 1,2,4-triazoles, 1,3-dithiane-1,1,3,3-tetraoxides,and 1,4-benzothiazin-3(4H)-one

Translated from Khimiko-farmatsevticheskii Zhurnal, Vol. 26, No. 2, pp. 38–41, February, 1992.     

An integrative psychophysiological approach to brain hemisphere functions in schizophrenia

The present paper proposes a new psychophysiological approach to the genesis of positive and negative schizophrenic symptoms. According to this approach, the initial factor in schizophrenic disorders is a functional insufficiency of the right hemisphere which can be determined by early emotional experience in combination with subtle brain damage. This functional insufficiency causes (a) the inability to grasp and select information before its realization; and (b) the inability to produce a polysemantic context which is crucial for creativity, psychological defense, and the restoration of search activity, all of which determine psychophysiological adaptation to the environment. Right hemisphere insufficiency causes left hemisphere hyperactivity as an ineffective attempt to compensate for this functional deficiency. As a result, normal search activity is replaced by artificial search activity which is represented by “positive” symptoms, and which uses the predisposition of the left hemisphere's catecholamine system for its increased activity. The suggestion is made that cognitive impairment in schizophrenia (the inability to use appropriate previous information in relation to current perceptual input) is related to the competition between information processing which requires left hemisphere activity, and the formation of positive symptoms, also based on left hemisphere activity.