排序方式: 共有18条查询结果,搜索用时 15 毫秒
1.
Mehmet Rasih Sonsoz Aytac Oncul Erdem Cevik Huseyin Orta Mustafa Yilmaz Elif Ayduk Govdeli Asli Nalbant Zeynep Gizem Demirtakan Mirac Tonyali Damla Durmus Ilkay Anakli Ozlem Polat Yunus Catma Naci Senkal Alpay Medetalibeyoglu Murat Kose Samim Emet Tufan Tukek 《The American journal of the medical sciences》2021,361(5):591-597
BackgroundThe information on electrocardiographic features of patients with coronavirus disease 2019 (COVID-19) is limited. Our aim was to determine if baseline electrocardiographic features of hospitalized COVID-19 patients are associated with markers of myocardial injury and clinical outcomes.MethodsIn this retrospective, single center cohort study, we included 223 hospitalized patients with laboratory-confirmed COVID-19. Clinical, electrocardiographic and laboratory data were collected and analyzed. Primary composite endpoint of mortality, need for invasive mechanical ventilation, or admission to the intensive care unit was assessed.ResultsForty patients (17.9%) reached the primary composite endpoint. Patients with the primary composite endpoint were more likely to have wide QRS complex (>120 ms) and lateral ST-T segment abnormality. The multivariable Cox regression showed increasing odds of the primary composite endpoint associated with acute respiratory distress syndrome (odds ratio 7.76, 95% CI 2.67–22.59; p < 0.001), acute cardiac injury (odds ratio 3.14, 95% CI 1.26–7.99; p = 0.016), high flow oxygen therapy (odds ratio 2.43, 95% CI 1.05–5.62; p = 0.037) and QRS duration longer than >120 ms (odds ratio 3.62, 95% CI 1.39–9.380; p = 0.008) Patients with a wide QRS complex (>120 ms) had significantly higher median level of troponin T and pro-BNP than those without it. Patients with abnormality of lateral ST-T segment had significantly higher median level of troponin T and pro-BNP than patients without.ConclusionsThe presence of QRS duration longer than 120 ms and lateral ST-T segment abnormality were associated with worse clinical outcomes and higher levels of myocardial injury biomarkers. 相似文献
2.
Kanbay Mehmet Medetalibeyoglu Alpay Kanbay Asiye Cevik Enes Tanriover Cem Baygul Arzu Şenkal Naci Konyaoglu Hilal Akpinar Timur S. Kose Murat Covic Adrian Tukek Tufan 《International urology and nephrology》2022,54(5):1097-1104
International Urology and Nephrology - Acute kidney injury (AKI) in COVID-19 patients is associated with poor prognosis. However, the incidence, risk factors and potential outcomes of AKI in... 相似文献
3.
Mehmet Hursitoglu Mehmet A. Cikrikcioglu Ahmet Danalioglu Tufan Tukek 《Central European Journal of Medicine》2010,5(2):145-149
Wilson’s disease is an autosomal-recessive disorder caused by mutation in the ATP7B gene. Absent or reduced function of ATP7B
protein leads to decreased hepatocellular excretion of copper into bile. Subsequent copper accumulation, first in the liver
but ultimately in the brain and other tissues, produces different clinical manifestations such as hepatic, neurological, hematological,
ophthalmological, and psychiatric problems. Diagnosis is based on clinical suspicion, parameters of copper metabolism, ophthalmic
examination (Kayser-Fleischer rings) and a liver biopsy. Genetic studies are of limited use. Early diagnosis and initiation
of therapy with chelators and therapeutic plasma exchange therapy are essential for prognosis. Liver transplantation corrects
the underlying pathophysiology and can be lifesaving in fulminant hepatic failure. Screening of siblings and 1st degree relatives
of the patients is also important. 相似文献
4.
M Hursitoglu MA Cikrikcioglu T Tukek I Beycan N Ahmedova S Karacuha M Sansal O Ozkan V Celik 《Transplant infectious disease》2009,11(1):28-32
Abstract: Background. Screening for latent tuberculosis infection before solid organ transplantation is mandatory, but this is not so easy in uremic patients on hemodialysis (HD) treatment. The newly developed interferon-gamma (IFN-γ)-based QuantiFERON® –TB Gold In-Tube test (QFT-G) seems to be superior to the other available tests.
Objective. To investigate the acute effect of the low-flux HD process on the results of the QFT-G assay.
Methods. A total of 56 HD patients participated in this prospective study. They were dialyzed under low-flux HD for at least 1 month before blood sampling for QFT-G assay. This assay was performed before and after the 4-h low-flux HD session.
Results. Compared with the pre-dialysis level, there was an obvious reduction in the IFN-γ production level (in response to the TB-antigen cocktails) after the HD process ( P =0.00). The pre-dialysis test result was negative in 21 (37.5%), positive in 33 (58.9%), and indeterminate in 2 (3.6%) patients. One pre-dialysis negative result changed to positive after the HD process. On the other hand, 7 pre-dialysis positive and 2 indeterminate results become negative after HD ( P =0.012).
Conclusion. In order to maintain the sensitivity of QFT-G assay in chronic renal failure patients on low-flux HD treatment, it is better to perform the test immediately before (not after) the HD process. 相似文献
Objective. To investigate the acute effect of the low-flux HD process on the results of the QFT-G assay.
Methods. A total of 56 HD patients participated in this prospective study. They were dialyzed under low-flux HD for at least 1 month before blood sampling for QFT-G assay. This assay was performed before and after the 4-h low-flux HD session.
Results. Compared with the pre-dialysis level, there was an obvious reduction in the IFN-γ production level (in response to the TB-antigen cocktails) after the HD process ( P =0.00). The pre-dialysis test result was negative in 21 (37.5%), positive in 33 (58.9%), and indeterminate in 2 (3.6%) patients. One pre-dialysis negative result changed to positive after the HD process. On the other hand, 7 pre-dialysis positive and 2 indeterminate results become negative after HD ( P =0.012).
Conclusion. In order to maintain the sensitivity of QFT-G assay in chronic renal failure patients on low-flux HD treatment, it is better to perform the test immediately before (not after) the HD process. 相似文献
5.
Mehmet Ali Cikrikcioglu Mehmet Hursitoglu Hafize Erkal Nilay Guler Karaca Sati Coraoglu Tufan Tukek 《Central European Journal of Medicine》2009,4(4):444-449
Our case involves a 53 year old woman. Three years ago, she was investigated because of normal hemoglobin levels despite very
a low erythrocyte count, which was revealed during the preoperative evaluation for ovarian cyst operation. The Direct Coombs
test was found to be positive against complement and negative against IgG. Cold agglutinin titer was 1/448 (+). Due to the
polyclonal IgM increase, secondary cold agglutinin disease (CAD) was considered but no factor could be found that would lead
to cold agglutinin disease. During the post-operative follow-up, cold agglutinin titers increased with fluctuations in the
patient. Twenty-four months after transabdominal hysterectomy and bilateral salpingooopherectomy operation, diagnosis of Hashimoto
disease was made upon detection of subclinical hypothyroidism. No case of Hashimoto disease associated with CAD caused by
polyclonal IgM has been reported until the present time. 相似文献
6.
Mehmet Hursitoglu Tufan Tukek Mehmet Ali Cikrikcioglu Osman Kara Rumeyza Kazancioglu Oktay Ozkan Mustafa Cakirca Fatih Akdogan Erdal Gundogan Sengul Aydin Ismet Beycan Meltem Gursu Serkan Dogan Aybala Erek 《Upsala journal of medical sciences》2012,117(1):22-27
Objective.
Urotensin II is a potent vasoactive peptide that has been implicated in the pathophysiology of many diseases. There is no study reporting the role and level of this peptide in recipients of kidney transplant. So we aimed to study the plasma levels of urotensin II in this group of patients.Methods.
Plasma urotensin II levels were analyzed in 110 subjects, who were divided into three groups: group 1 (35 kidney transplant recipients), group 2 (36 patients with chronic kidney disease), and group 3 (39 healthy controls).Results.
Analysis of logarithmic transformation of urotensin II, i.e. log (urotensin II × 1000) levels, with a one-way analysis of variance yielded a P value of 0.001. Post-hoc analysis showed significantly higher log (urotensin II × 1000) levels in group 1 than groups 2 and 3 (P = 0.001 and 0.017, respectively). One of the important features of the subjects of this group was that they were taking immunosuppressive drugs because of renal transplantation.Conclusions.
High urotensin II levels in recipients of kidney transplants could be drug-related (immunosuppressive drugs) and may be of practical importance that may be used to improve the long-term outcome of the patients. 相似文献7.
Mehmet Hursitoglu Osman Kara Mehmet A. Cikrikcioglu Tahsin Celepkulu Sengul Aydin Tufan Tukek 《Journal of clinical apheresis》2009,24(1):25-27
Here, we report a case of a 17‐year old female with Wilson's disease presenting with progressive Coombs' negative hemolytic anemia and hepatic cirrhosis who was treated with one session of therapeutic plasma exchange (TPE) and clinically improved. In clinical situations where multiple sessions of TPE may not be possible, the use of a single session of TPE in conjunction with conventional therapy may be of benefit in preventing further clinical deterioration. J. Clin. Apheresis, 2009. © 2009 Wiley‐Liss, Inc. 相似文献
8.
Yucel Arman Adem Atici Ozgur Altun Remzi Sarikaya Sengül Aydin Yoldemir Murat Akarsu Orkide Kutlu Guzin Zeren Ozturk Pinar Demir Mustafa Ozcan Recep Yilmaz Bayraktarli Tufan Tukek 《Arquivos brasileiros de cardiologia》2022,119(4):544
BackgroundPatients with prediabetes have an increased risk of atherosclerotic cardiovascular disease; therefore, early detection is important.ObjectiveThe present study aimed to reveal the usability of serum endocan levels as a biomarker in the diagnosis of subclinical atherosclerosis in patients with prediabetes, based on CIMT measurements.MethodsParticipants were classified according to the presence (n=42) or absence (n=42) of prediabetes. Serum endocan, fasting blood sugar, fasting insulin, and glycated hemoglobin (HbA1c) values of patients were examined, and CIMT was measured. The level of significance for statistical analysis was 0.05.ResultsWhile serum endocan levels were found to be lower in patients with prediabetes, when compared to the control group (p=0.042), CIMT values were found to be higher (p=0.046). When evaluated by multivariate regression analysis, the serum endocan level was found to be associated with CIMT, regardless of other parameters (p=0.007). A negative correlation was found between plasma fasting insulin and endocan levels (r=-0.320, p=0.001).ConclusionsCarotid intima media thickness was found to be high and the serum endocan level was low in patients with prediabetes. Decreased serum endocan levels in patients with prediabetes may be a contributing factor to atherosclerosis formation mechanisms. 相似文献
9.
Mehmet Hursitoglu Gulcin Sahingoz Erdal Esra Akdeniz Hakan Kocoglu Nursel Kocamaz Isil Ozbas Tevetoglu Haluk Yucel Ozlem Harmankaya Aytekin Guven Murat Akarsu Tufan Tukek Guzin Ozturk Halil Dogan Banu Karakus Yilmaz Mehmet Emin Gunes A. Baki Kumbasar 《The International journal of health planning and management》2019,34(2):872-879
10.
Cikrikcioglu MA Halac G Hursitoglu M Erkal H Cakirca M Kinas BE Erek A Yetmis M Gundogan E Tukek T 《Acta neurologica Belgica》2011,111(4):282-286
The prevalence of restless legs syndrome (RLS) is increased in gluten sensitive enteropathy (GSE); but prevalence of GSE is not known in RLS. 96 RLS patients and 97 healthy controls, both with or without iron deficiency were enrolled. All secondary RLS patients except iron deficiency were excluded. Subjects underwent a thorough biochemistry and routine blood analyses, and tissue transglutaminase antibodies (TTGA), endomysium antibodies (EMA) and gliadin antibodies (AGA) were also tested. In RLS patients positivity rates of all GSE antibodies were similar to those in controls. The rate of iron deficiency anaemia in RLS patients with at least one positive GSE antibody was significantly higher than that of RLS patients whose GSE antibodies were all negative. The prevalence of GSE antibodies in RLS patients is not increased. GSE might have a role in the aetiology of RLS in association with iron deficiency anaemia. Since the prevalence of GSE antibodies is not increased in RLS, it seems unlikely that GSE is involved in the aetiology of RLS through different mechanisms (e.g. immunological mechanisms) other than iron deficiency as proposed in some published papers. 相似文献