全文获取类型
收费全文 | 23624篇 |
免费 | 1038篇 |
国内免费 | 141篇 |
专业分类
耳鼻咽喉 | 166篇 |
儿科学 | 456篇 |
妇产科学 | 189篇 |
基础医学 | 3253篇 |
口腔科学 | 478篇 |
临床医学 | 1634篇 |
内科学 | 6472篇 |
皮肤病学 | 451篇 |
神经病学 | 1952篇 |
特种医学 | 1075篇 |
外科学 | 3729篇 |
综合类 | 98篇 |
一般理论 | 1篇 |
预防医学 | 547篇 |
眼科学 | 404篇 |
药学 | 1613篇 |
中国医学 | 67篇 |
肿瘤学 | 2218篇 |
出版年
2023年 | 115篇 |
2022年 | 203篇 |
2021年 | 365篇 |
2020年 | 189篇 |
2019年 | 258篇 |
2018年 | 357篇 |
2017年 | 278篇 |
2016年 | 328篇 |
2015年 | 376篇 |
2014年 | 488篇 |
2013年 | 613篇 |
2012年 | 941篇 |
2011年 | 1097篇 |
2010年 | 611篇 |
2009年 | 544篇 |
2008年 | 1044篇 |
2007年 | 1185篇 |
2006年 | 1093篇 |
2005年 | 1166篇 |
2004年 | 1185篇 |
2003年 | 1244篇 |
2002年 | 1255篇 |
2001年 | 702篇 |
2000年 | 673篇 |
1999年 | 704篇 |
1998年 | 368篇 |
1997年 | 296篇 |
1996年 | 279篇 |
1995年 | 261篇 |
1994年 | 280篇 |
1993年 | 243篇 |
1992年 | 574篇 |
1991年 | 442篇 |
1990年 | 476篇 |
1989年 | 478篇 |
1988年 | 425篇 |
1987年 | 388篇 |
1986年 | 367篇 |
1985年 | 393篇 |
1984年 | 259篇 |
1983年 | 242篇 |
1982年 | 147篇 |
1981年 | 110篇 |
1979年 | 200篇 |
1978年 | 126篇 |
1977年 | 126篇 |
1976年 | 108篇 |
1975年 | 112篇 |
1973年 | 115篇 |
1968年 | 113篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
1.
Loss‐of‐function mutations in the gene encoding filaggrin underlie a Japanese family with food‐dependent exercise‐induced anaphylaxis 下载免费PDF全文
2.
3.
4.
5.
6.
Yoshiki Imamura Takahiro Shinozaki Akiko Okada‐Ogawa Noboru Noma Masahiro Shinoda Koichi Iwata Akihiko Wada Osamu Abe Kelun Wang Peter Svensson 《Journal of oral rehabilitation》2019,46(6):574-587
Burning mouth syndrome (BMS) is a chronic oro‐facial pain disorder of unknown cause. It is more common in peri‐ and post‐menopausal women, and sex hormone dysregulation is believed to be an important causative factor. Psychosocial events often trigger or exacerbate symptoms, and persons with BMS appear to be predisposed towards anxiety and depression. Atrophy of small nerve fibres in the tongue epithelium has been reported, and potential neuropathic mechanisms for BMS are now widely investigated. Historically, BMS was thought to comprise endocrinological, psychosocial and neuropathic components. Neuroprotective steroids and glial cell line–derived neurotrophic factor family ligands may have pivotal roles in the peripheral mechanisms associated with atrophy of small nerve fibres. Denervation of chorda tympani nerve fibres that innervate fungiform buds leads to alternative trigeminal innervation, which results in dysgeusia and burning pain when eating hot foods. With regard to the central mechanism of BMS, depletion of neuroprotective steroids alters the brain network–related mood and pain modulation. Peripheral mechanistic studies support the use of topical clonazepam and capsaicin for the management of BMS, and some evidence supports the use of cognitive behavioural therapy. Hormone replacement therapy may address the causes of BMS, although adverse effects prevent its use as a first‐line treatment. Selective serotonin reuptake inhibitors (SSRIs) and serotonin and noradrenaline reuptake inhibitors (SNRIs) may have important benefits, and well‐designed controlled studies are expected. Other treatment options to be investigated include brain stimulation and TSPO (translocator protein 18 kDa) ligands. 相似文献
7.
8.
9.
Takao Itoi Atsushi Sofuni Fumihide Itokawa Yasushi Shinohara Kazuya Takeda Kazuto Nakamura Toshio Kurihara Takayoshi Tsuchiya Fuminori Moriyasu 《Digestive endoscopy》2006,18(3):232-238
We describe our methods and outcomes of multidisciplinary treatments in patients with unresectable hilar cholangiocarcinoma. Fifty‐seven patients with a known outcome were enrolled. Thirty‐four of 57 patients were treated and evaluated by salvage therapy. For salvage therapy, we used internal and external radiotherapy, photodynamic therapy, YAG laser therapy and microwave coagulation therapy. The median survival time was 548 days for the group receiving salvage therapy and 198 days for the group not receiving this treatment. In conclusion, although no randomization of the patients was performed in this retrospective study, our present data provide convincing evidence that salvage therapy is a useful therapeutic approach for unresectable hilar cholangiocarcinomas. 相似文献
10.
Toshio Kushiro Hiroshige Itakura Yoshihisa Abo Hiromi Gotou Shinji Terao Deborah L Keefe 《Hypertension research》2006,29(12):997-1005
Aliskiren is a novel orally active renin inhibitor for the treatment of hypertension. This study evaluated the antihypertensive efficacy, safety and tolerability of aliskiren in Japanese patients with hypertension. Forty hundred and fifty-five Japanese men and women with a mean sitting diastolic blood pressure of 95-110 mmHg were randomized to receive once-daily double-blind treatment for 8 weeks with aliskiren 75, 150 or 300 mg or placebo. Aliskiren produced significant, dose-dependent reductions in mean sitting diastolic blood pressure (p<0.0005 vs. placebo for each dose) and mean sitting systolic blood pressure (p<0.001 vs. placebo for each dose). The placebo-corrected reductions in mean sitting systolic/diastolic blood pressure were 5.7/4.0, 5.9/4.5 and 11.2/7.5 mmHg in the aliskiren 75, 150 and 300 mg groups, respectively. After 8 weeks' treatment, 27.8%, 47.8%, 48.2% and 63.7% of patients in the placebo and aliskiren 75, 150 and 300 mg groups, respectively, achieved a successful treatment response (diastolic blood pressure <90 mmHg and/or reduced by > or =10 mmHg from baseline; p<0.005 vs. placebo for each dose). Aliskiren treatment was well tolerated, with the incidence of adverse events reported in the active treatment groups (53-55%) being similar to that in the placebo group (50%). This study, which is the first to assess the antihypertensive efficacy and safety of aliskiren in Japanese patients with hypertension, demonstrates that the once-daily oral renin inhibitor aliskiren provides significant, dose-dependent reductions in blood pressure with placebo-like tolerability. 相似文献