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排序方式: 共有471条查询结果,搜索用时 15 毫秒
1.
G Freschi L Landi A Castagnoli A Taddei P Bechi G Bucciarelli 《European journal of surgical oncology》2006,32(5):577-582
AIMS: To report clinical outcomes of a large series of cases with advanced thyroid cancer. STUDY DESIGN: Three hundred and eighty-five patients at the UICC stages III and IV were selected for the study with thyroid cancer. RESULTS: Papillary carcinoma and sclerosing carcinoma have better survival than the Hürthle cell and insular types. Lymphatic metastasis does not appear to worsen the prognosis. All the tumour forms offer the chance of long survival. CONCLUSIONS: Surgical treatment is the primary treatment of thyroid carcinoma. The combined treatments of surgery, metabolic beam therapy, suppressive hormone therapy, radiotherapy and chemotherapy cure a high percentage of patients with the tumour at an advanced stage. 相似文献
2.
Maurizio Avella Ezio Martuscelli Gaetano Della Volpe Annalaura Segre Enrico Rossi Tonino Simonazzi 《Macromolecular chemistry and physics.》1986,187(8):1927-1943
The crystallization and thermal behaviour of crystallizable random propene/ethene copolymers (P-co-E) was systematically investigated. Index of crystallinity and, index of γ-form, enthalpy and entropy of fusion, equilibrium melting temperature, spherulite growth rate, and overall kinetic rate constant were determined and correlated with the overall ethene content and with the concentration of specific chemical defects as determined by 13C NMR analysis (PEP, EPP, EPE triads). The samples of the copolymers, obtained with very-high-yield Ziegler-Natta catalysts, were characterized by IR, 13C NMR, wide angle X-ray scattering, and differential scanning calorimetry. 相似文献
3.
First report of capsule replacement among electrophoretic type 37 Neisseria meningitidis strains in Italy
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Stefanelli P Fazio C Neri A Sofia T Mastrantonio P 《Journal of clinical microbiology》2003,41(12):5783-5786
This report describes the C-to-B capsular switching in four Neisseria meningitidis strains belonging to the electrophoretic type 37 (ET-37) complex. In particular, one strain belonged to the new sequence type 1860, which was first detected in the year 2000 in Italy and is now frequently isolated. The presence of switched serogroup B strains deserves special attention if they prove as able to spread as their serogroup C progenitors belonging to the hypervirulent ET-37 complex. 相似文献
4.
Hudson BI Wendt T Bucciarelli LG Rong LL Naka Y Yan SF Schmidt AM 《Antioxidants & redox signaling》2005,7(11-12):1588-1600
The major consequence of long-term diabetes is the increased incidence of disease of the vasculature. Of the underlying mechanisms leading to disease, the accumulation of advanced glycation end products (AGEs), resulting from the associated hyperglycemia, is the most convincing. Interaction of AGEs with their receptor, RAGE, activates numerous signaling pathways leading to activation of proinflammatory and procoagulatory genes. Studies in rodent models of macro- and microvascular disease have demonstrated that blockade of RAGE can prevent development of disease. These observations highlight RAGE as a therapeutic target for treatment of diabetic vascular disease. 相似文献
5.
Grandolfo ME Lauria L Medda E Bucciarelli M Andreozzi S Salinetti S Sitzia G Bernacchia R 《Annali dell'Istituto superiore di sanità》1999,35(2):341-347
The disappearance of diphtheria and poliomyelitis is the best evidence of the efficacy of the vaccination strategies adopted in Italy. The active offer of the prophylaxis, reinforced by law, has characterised the operational aspects of the strategy. The active surveillance system is the main tool to take under control the effectiveness of health services responsible for vaccination. This system could be more easily implemented if the health services will be given a specific software aiming to handle and evaluate vaccination registers. The present pilot study, performed in the regions Marche and Sardegna, is an example of active surveillance and it is based on the ARVA software produced by the Istituto Superiore di Sanità. The results show a good level of coverage (> 95%) within the second year of life. Unsatisfactory results were obtained on the timing of vaccinations, as recommended by the vaccination schedule, mostly for the third doses. 相似文献
6.
M Mandalà G Curigliano P Bucciarelli G Ferretti P M Mannucci M Colleoni A Ventura G Peruzzotti G Severi P G Pelicci R Biffi F Orsi S Cinieri A Goldhirsch 《Annals of oncology》2004,15(4):590-593
BACKGROUND: To analyze the influence of the prothrombotic gene mutation factor V G1691A (factor V Leiden) and prothrombin G20210A on the risk of a first episode of catheter-related deep venous thrombosis (DVT) in a group of patients with breast cancer treated with chemotherapy. PATIENTS AND METHODS: Between January 1999 and February 2001, the occurrence of a first symptomatic DVT was investigated in a cohort of 300 consecutive patients with locally advanced or metastatic breast cancer treated at a single institution with fluorouracil-based chemotherapy, administered continuously through a totally implanted access port. A nested case-control study included 25 women (cases) with catheter-related DVT and 50 controls without DVT matched with cases for age, identical chemotherapy, stage of disease and prognostic features. The G1691A factor V and G20210A prothrombin mutation genotypes were analyzed. RESULTS: Five cases [20%; 95% confidence interval (CI) 9% to 39%)] and two controls (4%; 95% CI 1% to 14%) were heterozygous carriers of G1691A factor V (P = 0.04). The age-adjusted odds ratio for catheter-related DVT was 6.1 (95% CI 1.1-34.3). Only one patient (case) had the G20210A prothrombin gene mutation. Time from start of chemotherapy infusion to DVT was not significantly different between patients with (median 31 days) and without (median 43 days) G1691A factor V mutation (P = 0.6). CONCLUSIONS: Factor V Leiden carriers with locally advanced or metastatic breast cancer have an increased risk of developing catheter-related DVT during chemotherapy. 相似文献
7.
Amicarelli F; Bucciarelli T; Poma A; Aimola P; Di Ilio C; Ragnelli AM; Miranda M 《Carcinogenesis》1998,19(3):519-523
The effects of methylglyoxal on the growth of a line of human melanoma
cells are investigated. Methylglyoxal inhibits cell growth in a dose-
dependent manner and causes an increase in glyceraldehyde 3-phosphate
dehydrogenase, and glyoxalase 1 and glyoxalase 2 specific activities. The
cellular response to increasing concentrations of methylglyoxal in the
culture medium is also studied by measuring L-lactate production,
reduced-oxidized glutathione levels and apoptotic cell death. Methylglyoxal
seems to promote a change of cell population phenotypic repertoire toward a
more monomorphic phenotype. In conclusion, methylglyoxal seems to induce an
enzymatic cellular response that lowers methylglyoxal levels and selects
the most resistant cells.
相似文献
8.
9.
Metabolically controlled reperfusion in acute myocardial infarction: should the polarizing solution be given subselectively? 总被引:2,自引:0,他引:2
Angelini P Haas PC Bucciarelli Ducci C Adams S Ober J Bigley J Clubb FJ Frazier OH 《The Journal of invasive cardiology》2003,15(9):491-496
BACKGROUND: In working rat hearts, metabolic support of injured tissue enhances recovery after acute myocardial infarction. Clinical experience with a systemic "polarizing solution" supports this claim. OBJECTIVES: In a dog model of ischemia/reperfusion, we tested the feasibility of subselectively supplying adapted metabolic substrates before instituting blood reperfusion. METHODS: Thirty-five dogs underwent ligation of the proximal left anterior descending artery and collaterals for 90 minutes. The animals were randomly assigned to receive direct blood reperfusion (Group I), intracoronary glucose, insulin, and potassium (Group II), or intracoronary glucose, insulin, and potassium plus propionyl-L-carnitine (PLC) (Group III). After 30 minutes of artificial reperfusion, prograde blood flow was resumed in groups II and III. A routine necropsy was performed 3 to 5 days later. Primary endpoints were severe arrhythmias, death, markers of infarct size, and specific histologic features. RESULTS: We excluded 4 dogs for technical reasons and 2 others for preexisting cardiomyopathy. In the remaining 29 animals, large apical infarctions were documented ventriculographically during arterial ligation. One dog died of irreversible ventricular fibrillation during the initial ischemic period, and 9/28 dogs (32.1%) died during early reperfusion. Ventricular fibrillation was more common with 10% (versus 5%) dextrose concentrations and was eliminated by PLC. Irreversibly injured (versus jeopardized) areas of myocardium were more common in Group III (85.9 19.3%) than in Groups I and II (16.9 10.8%). CONCLUSION: Subselective infusion of metabolically supportive solutions during acute myocardial infarction is technically feasible. To prevent osmotic endothelial damage, the perfusate must have a low (< 5%) dextrose content. 相似文献
10.
The effect of recanalization on long‐term neurological outcome after cerebral venous thrombosis
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E. Rezoagli I. Martinelli D. Poli U. Scoditti S. M. Passamonti P. Bucciarelli W. Ageno F. Dentali 《Journal of thrombosis and haemostasis》2018,16(4):718-724
Essentials
- The role of cerebral venous thrombosis (CVT) recanalization on neurologic outcome is still debated.
- We studied a large cohort of 508 CVT patients with 419 patient years of radiological follow‐up.
- Recanalization rate is high during the first months after CVT and neurologic outcome is favorable.
- High recanalization grade of CVT independently predicts good neurological outcome.