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1.
C McKenzie BAppSc P Megaw BAppSc I Morgan PhD MK Boelen PhD 《Clinical & experimental ophthalmology》1997,25(4):79-81
Deprivation of form vision by the fitting of translucent occluders suppressed the diurnal cycling of enkephalinergic amacrine cells (the ENSLI amacrine cells), in the chicken. Daily periods of normal vision or enforcing temporal contrast using strobe lighting appeared to restore normal functioning of the ENSLI cells. These results suggest that the ENSLI cells are involved in retinal circuits that assess the quality of the visual image and control eye growth. 相似文献
2.
Oscar A. Alvarez M.D. Judith A. Maples M.D. Fermin O. Tio M.D. Makau Lee M.D. Ph.D. 《The American journal of gastroenterology》1995,90(8):1350-1351
Cokeromyces recurvatus , a sporangiola-forming dimorphic is a rare cause of urogenital infection in humans. We report here a case of severe watery diarrhea due lo C. recurvains , which was treated successfully with high-dose oral nystatin therapy. We speculate that our patient was probably predisposed to infections due to opportunistic organisms, such as C. recurvatus , because of post-transplantation immunosuppression. To our knowledge, our patient represents the first documented case of diarrhea due to C. recurvatus in man und this ease highlights the potential pathogenic capability of this opportunistic organism in immunosuppressed patients. 相似文献
3.
A promising technique for transplantation of bone marrow-derived endothelial progenitor cells into rat heart. 总被引:2,自引:0,他引:2
Cheng Qian René A Tio Anton J M Roks Kristien M Boddeus Martin C Harmsen Wiek H van Gilst Regien G Schoemaker 《Cardiovascular pathology》2007,16(3):127-135
OBJECTIVE: To investigate the feasibility of intracoronary application of endothelial progenitor cells and the subsequent distribution within the heart. METHODS: Endothelial progenitors cells (EPCs) cultured from rat bone marrow were identified by double-positive staining with Dil-Ac-LDL and BS1-lectin. Twenty-four hours before cell transplantation, EPCs were labeled with 5-bromo-2'-deoxyuridine (BrdU). Cells (5 x 10(5) in 250-microl medium) were injected into healthy rats, either as intracoronary application (n=11) or as intramyocardial injection (n = 6). At 15 min or 3 days posttransplantation, hearts as well as other organs (lung, liver, kidney, and spleen) were collected and processed for subsequent BrdU immunohistochemistry. The number of BrdU-positive cells per tissue area was counted. RESULTS: Compared to intramyocardial injection, intracoronary administration resulted in more than twice as much positive cells in the heart (P < .05), with no local differences within the heart. Whereas after 15 min, EPCs were equally distributed in all examined organs (except for the spleen), cells that were still present after 3 days, approximately 10%, were selectively restricted to the heart. CONCLUSIONS: Our data indicate that the intracoronary application provides a promising technique for EPC transplantation in the rat heart. 相似文献
4.
Rachel Wuerstlein Nadia Harbeck Eva-Maria Grischke Dirk Forstmeyer Raquel von Schumann Petra Krabisch Kerstin Lüdtke-Heckenkamp Andrea Stefek Oliver Stoetzer Andrea Grafe Gabriele Kaltenecker Helmut Forstbauer Doris Augustin Iris Schrader Joke Tio Ulrike Nitz Oleg Gluz Ronald E. Kates Monika Karla Graeser 《Breast care (Basel, Switzerland)》2021,16(1):50
BackgroundProtroca evaluated the efficacy and safety of primary and secondary prophylaxis of neutropenia with lipegfilgrastim (Lonquex®) in breast cancer patients receiving neoadjuvant or adjuvant chemotherapy (CT).Patients and MethodsOf the 255 patients enrolled, 248 patients were evaluable for the intent-to-treat (ITT) and 194 patients for the per-protocol set. Primary and secondary end points after lipegfilgrastim treatment were assessed.ResultsNine patients of the ITT set receiving lipegfilgrastim as primary prophylaxis (n = 222) had febrile neutropenia of grade 3–4 (5 patients) or infection of grade 3–4 (4 patients); 1/26 of those receiving secondary prophylaxis had an event. Dose reductions were performed in 9.5% of the patients. Postponement of cancer CT cycles for >3 days occurred in <15% of patients; 10.8% (92/851 AEs) and 8% (2/25 SAEs) of documented adverse events and serious adverse events, respectively, were related to lipegfilgrastim.ConclusionsApplication of lipegfilgrastim was effective as primary and secondary prophylaxis in the prevention of CT-induced neutropenia in breast cancer. 相似文献
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6.
Differentiation of abdominal masses detected on prenatal ultrasound is difficult and requires careful characterization of the mass and precise localization. Differentiation is required in order to distinguish benign from potentially malignant conditions. We describe a case of fetus‐in‐fetu with pre and postnatal imaging. 相似文献
7.
Geluk CA Dikkers R Perik PJ Tio RA Götte MJ Hillege HL Vliegenthart R Houwers JB Willems TP Oudkerk M Zijlstra F 《European radiology》2008,18(2):244-252
We determined the efficiency of a screening protocol based on coronary calcium scores (CCS) compared with exercise testing
in patients with suspected coronary artery disease (CAD), a normal ECG and troponin levels. Three-hundred-and-four patients
were enrolled in a screening protocol including CCS by electron beam computed tomography (Agatston score), and exercise testing.
Decision-making was based on CCS. When CCS≥400, coronary angiography (CAG) was recommended. When CCS<10, patients were discharged.
Exercise tests were graded as positive, negative or nondiagnostic. The combined endpoint was defined as coronary event or
obstructive CAD at CAG. During 12±4 months, CCS≥400, 10–399 and <10 were found in 42, 103 and 159 patients and the combined
endpoint occurred in 24 (57%), 14 (14%) and 0 patients (0%), respectively. In 22 patients (7%), myocardial perfusion scintigraphy
was performed instead of exercise testing due to the inability to perform an exercise test. A positive, nondiagnostic and
negative exercise test result was found in 37, 76 and 191 patients, and the combined endpoint occurred in 11 (30%), 15 (20%)
and 12 patients (6%), respectively. Receiver-operator characteristics analysis showed that the area under the curve of 0.89
(95% CI: 0.85–0.93) for CCS was superior to 0.69 (95% CI: 0.61–0.78) for exercise testing (P<0.0001). In conclusion, measurement of CCS is an appropriate initial screening test in a well-defined low-risk population
with suspected CAD. 相似文献
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10.
de Jonge GJ van Ooijen PM Piers LH Dikkers R Tio RA Willems TP van den Heuvel AF Zijlstra F Oudkerk M 《European radiology》2008,18(11):2425-2432
The purpose of this study is to assess the capability of dual-source computed tomography (DSCT) in evaluating coronary artery
anomalies. Early detection and evaluation of coronary artery anomalies is essential because of their potential association
with myocardial ischemia and sudden death. In 16 patients (12 men, mean age 50 ± 14 years), anomalous coronary arteries were
detected on contrast-enhanced DSCT in a patient cohort of 230 individuals (incidence of 7%). Six different types of anomalies
were diagnosed (three fistula, four anomalies of the circumflex artery, four anomalous right coronary arteries, three anomalies
of the left coronary artery, one absent left main coronary artery, and one left coronary artery arising from the pulmonary
trunk). Of the 16 patients, 10 also underwent conventional coronary angiography (CAG). Retrospective evaluation of the CAGs
by an experienced interventional cardiologist resulted in a precise diagnosis in 50% of patients. With DSCT, sufficient image
quality and exact visualization of the aberrant anatomy were achieved in all patients. Therefore, DSCT seems to be an accurate
diagnostic tool for examining the precise origin, course, and shape of aberrant coronary arteries. 相似文献