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排序方式: 共有294条查询结果,搜索用时 15 毫秒
1.
Detection of hepatocellular carcinoma after interferon therapy for chronic hepatitis C: Clinical study of 26 cases 总被引:1,自引:0,他引:1
NOBUYUKI SUGIURA YUZOH SAKAI MASAAKI EBARA HIROYUKI FUKUDA MASAHARU YOSHIKAWA HIROMITSU SAISHO MASAO OHTO FUKUO KONDO 《Journal of gastroenterology and hepatology》1996,11(6):535-539
The clinical findings in 26 patients in whom hepatocellular carcinoma (HCC) was detected after the start of interferon (IFN) therapy for chronic hepatitis C were analysed. Histological study before IFN therapy showed that 34.6% of patients were categorized as stage 3 (septal fibrosis with architectural distortion; the 0–4 scale) and 80.8% demonstrated at least some evidence of septal fibrosis or more advanced features. The AFP levels examined before IFN therapy were more than 20 ng/mL in 13 patients (84.6% of those studied). One of 26 patients had a complete response to IFN therapy, while six of 26 patients had only a partial response. HCC was detected within 1 year after the start of IFN therapy in 76.9% of patients. Thus, the possibility of the early occurrence of HCC or its existence at the time of therapy should be seriously considered when IFN therapy is contemplated. Patients with stage 3 or 3–4 histology may already have a small undetectable HCC before IFN therapy. Thus, for this reason, every patient treated with IFN should be examined at short regular intervals for the development of HCC during and after IFN therapy. 相似文献
2.
R. I. RICHARDS J. CRAWFORD K. NARAHARA † M. MANGELSDORF K. FRIEND A. STAPLES M. DENTON S. EASTEAL T.-A. HORI I. KONDO T. JENKINS A. GOLDMAN V. PANICH E. FERAKOVA G. R. SUTHERLAND 《Annals of human genetics》1996,60(5):391-400
To assess the relative contributions of trans -acting factors (replication and repair functions) and cis -acting elements (repeat and flanking DNA composition) to the mechanism of trinucleotide repeat sequence mutation we have analysed the distribution of copy number polymorphisms at 12 loci associated with dynamic mutations in 15 populations of different ethnic origins. Genome wide instability of repeats in a particular population would be evidence of trans -acting factor instigation of the mutation process, whereas instability at a particular locus (perhaps even in several populations) would be evidence that the composition of the particular locus was the most significant factor contributing to mutation. The FRA16A locus is highly polymorphic in only the European population. Some other loci exhibit distinct distributions of alleles between different populations. Therefore sequences in the vicinity of the repeat - the cis component of a particular locus - appear(s) to be more important in the mutation mechanism than sporadic genome-wide instability induced by trans -acting factors such as the DNA mismatch repair enzymes. 相似文献
3.
Itoh Y Igarashi T Tatsuma N Imai T Yoshida J Tsuchiya M Murakami M Fukunaga Y 《Autoimmunity》2000,32(3):193-197
We have previously reported that approximately 50% of children with chronic nonspecific complaints were positive for antinuclear antibodies (ANA), and that a novel autoantibody to a 62 kD protein (anti-Sa) was found in 40% of these ANA-positive patients. Therefore, we proposed a distinct disease entity termed autoimmune fatigue syndrome (AIFS). We hypothesized that if autoimmune mechanisms did play an important role in the pathogenesis of AIFS, it is possible that it is immunogenetically regulated as observed in other autoimmune disorders. In order to examine the immunogenetic background of AIFS patients, HLA-A, -B, -C, and -DR loci were analyzed serologically in 61 AIFS patients. AIFS was found to be positively associated with the class I antigen HLA-B61 and with the class II antigen HLA-DR9, with odds ratios of 2.77 (p = 0.015, Pcorr = 0.48) and 2.60 (p= 0.012, Pcorr = 0.17), respectively. A negative association was also found between AIFS and HLA-DR2 with odds ratio of 0.25 (p = 0.029, Pcorr = 0.041). When comparing anti-Sa positive AIFS patients with healthy controls, the odds ratios associated with HLA-B61, DR9, and DR2 were 3.42 (p = 0.021, Pcorr = 0.22), 3.96 (p = 0.0011, Pcorr = 0.015), and 0.16 (p = 0.0022, Porr = 0.031), respectively. Thus, the HLA associations observed in this study suggested that immunogenetic background might play a role in AIFS. 相似文献
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Satoi Sohei Yamamoto Tomohisa Yamaki So Hirooka Satoshi Hashimoto Daisuke Sakaguchi Tatsuma Ryota Hironori Yui Rintaro Sakuramoto Kazuto Matsushima Hideyuki Yanagimoto Hiroaki Toyokawa Hideyoshi Michiura Taku Inoue Kentaro Sekimoto Mitsugu 《胰腺病学杂志(英文)》2021,(2):99-105
Objective::No ideal training system exists for pancreaticoduodenectomy (PD). We developed an educational system that uses an objective structured assessment of ... 相似文献