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Rickets, whether due to lack of proper nutrition or secondary to disease or medication, may be unexpectedly detected on radiographs obtained for other reasons. Several recent examples are reported here. It is important to be aware of the manifestations of rickets so that appropriate treatment is not delayed. Physicians should be alert for signs of rickets in the x-ray examination of any child. 相似文献
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Heidi E. Jones Sheri A. Lippman Helio H. Caiaffa-Filho Taryn Young Janneke H. H. M. van de Wijgert 《Journal of clinical microbiology》2013,51(3):1037-1039
Women participating in studies in Brazil (n = 695) and South Africa (n = 230) performed rapid point-of-care tests for Trichomonas vaginalis on self-collected vaginal swabs. Using PCR as the gold standard, rapid self-testing achieved high specificity (99.1%; 95% confidence interval [CI], 98.2 to 99.6%) and moderate sensitivity (76.7%; 95% CI, 61.4 to 88.2%). These tests may be considered an alternative to syndromic management in resource-poor settings. 相似文献
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Epidemiological study of paediatric germ cell tumours revealed the incidence and distribution that was expected,but a low mortality rate
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Varma MG Wang JY Berian JR Patterson TR McCrea GL Hart SL 《Diseases of the colon and rectum》2008,51(2):162-172
Purpose This study was designed to develop and test the validity and reliability of the Constipation Severity Instrument.
Methods Scale development was conducted in two stages: 1) 74 items were generated through a literature review and focus groups of
constipated patients and medical providers; and 2) a preliminary instrument was administered to 191 constipated patients and
103 healthy volunteers. Test-retest reliability of the constipated group was assessed (N = 90). Content, convergent, divergent,
and discriminant validity were evaluated by using other validated measures by performing one-way analysis of variance and
Pearson correlations.
Results Exploratory and confirmatory factor analysis revealed three subscales: obstructive defecation, colonic inertia, and pain.
Internal consistency (α = 0.88–0.91) and test-retest reliability (intraclass correlation coefficients = 0.84–0.91) were high
for all subscales. Constipated patients were grouped by Rome II criteria: functional constipation (22 percent), pelvic floor
dyssynergia (15 percent), constipation predominant irritable bowel syndrome (23 percent), and no specific criteria (40 percent).
Those with constipation predominant irritable bowel syndrome or pelvic floor dyssynergia scored higher on the Obstructive
Defecation and Colonic Inertia subscales than those with functional constipation or no specific criteria (P = 0.001–0.058). Subjects with functional constipation had much lower scores on the pain subscale than constipation predominant
irritable bowel syndrome, functional constipation, or no specific criteria (P < 0.009).The Constipation Severity Instrument subscale and total score correlated very highly with the subscales and total
score of the Patient Assessment of Constipation Symptom measure. The Constipation Severity Instrument subscales discriminated
well between constipated patients and healthy volunteers (P < 0.001) and demonstrated excellent divergent validity. Higher Constipation Severity Instrument scores inversely correlated
with general quality of life.
Conclusions The Constipation Severity Instrument is a reliable and valid instrument for assessing constipated patients. Administration
of the Constipation Severity Instrument to other constipated patients will further validate its use.
Supported by the University of California San Francisco Hellman Family Award for Early Career Faculty.
Read at the meeting of The American Society of Colon and Rectal Surgeons, St. Louis, Missouri, June 2 to 6, 2007.
Reprints are not available. 相似文献