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Rituximab for recurrent IgA nephropathy in kidney transplantation: A report of three cases and proposed mechanisms 下载免费PDF全文
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Kulwara Meksawan Chorsakon Chaotrakul Napat Leeaphorn Suthep Gonlchanvit Somchai Eiam-Ong Talerngsak Kanjanabuch 《Peritoneal dialysis international》2016,36(1):60-66
♦ Background:
Fructo-oligosaccharides (FOS) exhibit soluble-fiber properties that beneficially affect bowel function and relieve constipation. The effects of FOS supplementation on constipation and biochemical parameters were examined in elderly continuous ambulatory peritoneal dialysis (CAPD) patients.♦ Methods:
This randomized, double-blind, placebo-controlled, cross-over study was performed in elderly CAPD patients (5 males and 4 females) with chronic constipation. All subjects were randomly assigned to receive either 20 g FOS or placebo daily for 30 days. After a 14-day washout period, the patients were switched to the other substance for 1 more month. Before and after each treatment period, frequency of defecation, characteristics of feces, and colonic transit were evaluated. Biochemical parameters were also assessed.♦ Results:
Fructo-oligosaccharides significantly increased the frequency of defecation (10.5 ± 2.0 vs 6.2 ± 1.4 times per week, p < 0.005) and changed the feces'' appearance from type 1 (nut-like) to type 4 (sausage–like). The colonic transit determined by geometric center (GC) was augmented after FOS supplementation (3.9 ± 0.3 vs 3.2 ± 0.4, p < 0.05). Fructo-oligosaccharides had no effects on biochemical parameters. Fructo-oligosaccharides caused mild discomforts which were well tolerated after dose adjustment.♦ Conclusions:
Fructo-oligosaccharide supplementation is effective, well tolerated, and can be an alternative to other laxatives in CAPD patients with constipation. Further studies are needed to better assess the biochemical effects of FOS in the chronic kidney disease population. 相似文献4.
Kittiskulnam Piyawan Chuengsaman Piyatida Katesomboon Sirarat Praditpornsilpa Kearkiat Tungsanga Kriang Eiam-Ong Somchai Kanjanabuch Talerngsak 《International urology and nephrology》2022,54(2):437-446
International Urology and Nephrology - Progressive decline in lean mass and gain of fat mass are common in patients treated with peritoneal dialysis (PD). It is unclear whether body composition or... 相似文献
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Prevention of obesity and insulin resistance in mice lacking plasminogen activator inhibitor 1 总被引:22,自引:0,他引:22
Ma LJ Mao SL Taylor KL Kanjanabuch T Guan Y Zhang Y Brown NJ Swift LL McGuinness OP Wasserman DH Vaughan DE Fogo AB 《Diabetes》2004,53(2):336-346
Increased plasminogen activator inhibitor 1 (PAI-1) has been linked to not only thrombosis and fibrosis but also to obesity and insulin resistance. Increased PAI-1 levels have been presumed to be consequent to obesity. We investigated the interrelationships of PAI-1, obesity, and insulin resistance in a high-fat/high-carbohydrate (HF) diet-induced obesity model in wild-type (WT) and PAI-1-deficient mice (PAI-1(-/-)). Obesity and insulin resistance developing in WT mice on an HF diet were completely prevented in mice lacking PAI-1. PAI-1(-/-) mice on an HF diet had increased resting metabolic rates and total energy expenditure compared with WT mice, along with a marked increase in uncoupling protein 3 mRNA expression in skeletal muscle, likely mechanisms contributing to the prevention of obesity. In addition, insulin sensitivity was enhanced significantly in PAI-1(-/-) mice on an HF diet, as shown by euglycemic-hyperinsulinemic clamp studies. Peroxisome proliferator-activated receptor (PPAR)-gamma and adiponectin mRNA, key control molecules in lipid metabolism and insulin sensitivity, were maintained in response to an HF diet in white adipose tissue in PAI-1(-/-) mice, contrasting with downregulation in WT mice. This maintenance of PPAR-gamma and adiponectin may also contribute to the observed maintenance of body weight and insulin sensitivity in PAI-1(-/-) mice. Treatment in WT mice on an HF diet with the angiotensin type 1 receptor antagonist to downregulate PAI-1 indeed inhibited PAI-1 increases and ameliorated diet-induced obesity, hyperglycemia, and hyperinsulinemia. PAI-1 deficiency also enhanced basal and insulin-stimulated glucose uptake in adipose cells in vitro. Our data suggest that PAI-1 may not merely increase in response to obesity and insulin resistance, but may have a direct causal role in obesity and insulin resistance. Inhibition of PAI-1 might provide a novel anti-obesity and anti-insulin resistance treatment. 相似文献
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Aldigier JC Kanjanbuch T Ma LJ Brown NJ Fogo AB 《Journal of the American Society of Nephrology : JASN》2005,16(11):3306-3314
In this study, the effects of inhibition of aldosterone on regression of existing hypertension-related glomerulosclerosis were investigated. Adult male Sprague Dawley rats (220 to 250 g) underwent 5/6 nephrectomy (Nx). Severity of glomerulosclerosis was assessed by renal biopsy 8 wk later, and rats were divided into four groups with equal biopsy sclerosis and then randomized by group to 4-wk treatments as follows: Control with no further treatment (CONT; n = 6); spironolactone (SP) alone (200 mg/kg per d, by gavage, n = 6); or SP combined with nonspecific triple antihypertensive drugs (TRX; reserpine, hydralazine, and hydrochlorothiazide in drinking water; SP+TRX, n = 7) or with angiotensin type 1 receptor antagonist (AT1RA; losartan in drinking water; SP+AT1RA, n = 8). When the rats were killed 12 wk after Nx, autopsy glomerulosclerosis index (SI; 0 to 4+ scale) was compared with biopsy SI in the same rats. Systolic BP was increased at 8 wk after Nx and continued to increase at 12 wk after Nx in the CONT and SP groups but not in SP+TRX- or SP+AT1RA-treated rats. Serum creatinine at 12 wk was significantly decreased in all SP-treated groups versus CONT. CONT rats had on average a 157% increase in SI from biopsy to killing at 12 wk, compared with only 84% increase in SP rats, with regression of SI in some rats. The effects on glomerulosclerosis by SP were further enhanced (when systolic BP was controlled by TRX or by AT1RA). It is concluded that inhibition of aldosterone by SP not only slows development of glomerulosclerosis but also induces regression in some rats of existing glomerulosclerosis. 相似文献
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Virojanawat Mathurot Puapatanakul Pongpratch Chuengsaman Piyatida Boonyakrai Chanchana Buranaosot Sompon Katavetin Pisut Praditpornsilpa Kearkiat Eiam-Ong Somchai Kanjanabuch Talerngsak 《International urology and nephrology》2021,53(7):1463-1471
International Urology and Nephrology - Hypokalemia is highly prevalent in chronic peritoneal dialysis (PD) patients worldwide, particularly in Thailand. This study aims to investigate the major... 相似文献
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Siriwanij T Suttinont C Tantawichien T Chusil S Kanjanabuch T Sitprija V 《Nephrology (Carlton, Vic.)》2005,10(1):1-6
BACKGROUND: Haemodynamics in leptospirosis may differ from that of sepsis because of frequently obeserved myocarditis and severe cholestatic jaundice. A haemodynamic study was therefore made in 10 patients with severe leptospirosis. METHODS AND RESULTS: All patients had pulmonary complications with a chest X-ray showing either pulmonary oedema or infiltration. Renal failure was present in nine patients. Three patterns of haemodynamics were revealed. The first pattern was observed in six patients who showed increased cardiac index, decreased systemic vascular resistance, normal pulmonary capillary wedge pressure, normal pulmonary vascular resistance and hypotension. The pattern resembled that of sepsis. The second pattern shown in two patients with haemoptysis consisted of a normal cardiac index, normal systemic vascular resistance, normal blood pressure, normal pulmonary capillary wedge pressure and increased pulmonary vascular resistance. The third pattern was observed in two patients with severe jaundice who had hypotension, a relatively low cardiac index, increased systemic vascular resistance and normal pulmonary capillary wedge pressure, and pulmonary vascular resistance. Plasmapheresis performed in two patients and continuous venovenous haemofiltration performed in two patients improved systemic haemodynamics and normalized blood pressure with a resolution of lung signs. 相似文献
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Sarinya Boongird Jeerath Phannajit Talerngsak Kanjanabuch Piyatida Chuengsaman Phongsak Dandecha Guttiga Halue Pichet Lorvinitnun Chanchana Boonyakrai Worapot Treamtrakanpon Sajja Tatiyanupanwong Niwat Lounseng Jeffrey Perl David W. Johnson Roberto Pecoits-Filho Suchai Sritippayawan Kriang Tungsanga Surasak Kantachuvesiri Vuddhidej Ophascharoensuk Thailand PDOPPS Steering Committee Advisory Board of Peritoneal Dialysis The Nephrology Society of Thailand 《Nephrology (Carlton, Vic.)》2023,28(Z1):14-23
Aim
To assess whether the peritoneal dialysis (PD) centres included in the Peritoneal Dialysis Outcomes and Practise Patterns Study (PDOPPS) in Thailand are representative of other PD centres in the country, based on 8 key performance indicators (KPIs 1–8).Methods
A retrospective analysis was conducted comparing PD-related clinical outcomes between PD centres included in the PDOPPS (the PDOPPS group) and those not included (the non-PDOPPS group) from January 2018 to December 2019. Logistic regression analysis was used to identify predictors associated with achieving the target KPIs.Results
Of 181 PD centres, 22 (12%) were included in the PDOPPS. PD centres in the PDOPPS group were larger and tended to serve more PD patients than those in the non-PDOPPS group. However, the process and outcome KPIs (KPIs 1–8) were comparable between the 2 groups. Large hospitals (≥120 beds), providing care to ≥100 PD cases and having experience for >10 years were independent predictors of achieving the peritonitis rate target of <0.5 episodes/year. Most PD centres in Thailand showed weaknesses in off-target haemoglobin levels and culture-negative peritonitis rate.Conclusions
The PD centres included in Thai PDOPPS were found to be representative of other PD centres in Thailand in terms of clinical outcomes. Thus, Thai PDOPPS findings may apply to the broader PD population in Thailand. 相似文献10.
Pranart Chiowanich Talerngsak Kanjanabuch Srivadee Oravivattanakul Viroj Wiwanitkit 《Diabetes & Metabolic Syndrome: Clinical Research & Reviews》2009,3(3):152-154
ObjectiveTo identify prevalence of microalbuminuria and its associated risk factors including old age, hypertension, dyslipidemia, diabetic retinopathy and metabolic syndrome in diabetic patients in Lampang, Thailand.Material and method2231 diabetic patients at Lampang Hospital were recruited in this cross-sectional study. Eye examination, blood pressure and abdominal circumference measurements were done. Blood was collected and checked for glucose, cholesterol, and renal function. Single-spot morning urine was collected for urine albumin–creatinine ratio (UACR). UACR 30–300 mg/g indicated microalbuminuria (by National Kidney Foundation). Multivariate logistic regression method including odds ratio and 95% confidence interval were used to analyze the data.ResultsMicroalbuminuria was found in 27% of the patients. There were clear association between creatinine clearance and microalbuminuria. Older age for every 10 years and diabetic retinopathy had relationship with microalbuminuria in overall and female patients while had no statistically significant in male patients.ConclusionMicroalbuminuria is common in Thai diabetic patients. Older age and history of diabetic retinopathy increase the risk of microalbuminuria in overall and female patients. Screening for albuminuria should be done in every diabetic patient for early prevention of diabetic nephropathy. 相似文献