全文获取类型
收费全文 | 229篇 |
免费 | 9篇 |
国内免费 | 6篇 |
专业分类
儿科学 | 1篇 |
妇产科学 | 2篇 |
基础医学 | 30篇 |
口腔科学 | 22篇 |
临床医学 | 5篇 |
内科学 | 32篇 |
皮肤病学 | 5篇 |
神经病学 | 20篇 |
特种医学 | 4篇 |
外科学 | 28篇 |
综合类 | 6篇 |
预防医学 | 3篇 |
药学 | 10篇 |
肿瘤学 | 76篇 |
出版年
2023年 | 2篇 |
2022年 | 1篇 |
2021年 | 4篇 |
2020年 | 7篇 |
2019年 | 2篇 |
2018年 | 10篇 |
2017年 | 4篇 |
2016年 | 5篇 |
2015年 | 1篇 |
2014年 | 5篇 |
2013年 | 7篇 |
2012年 | 8篇 |
2011年 | 12篇 |
2010年 | 4篇 |
2009年 | 3篇 |
2008年 | 6篇 |
2007年 | 7篇 |
2006年 | 6篇 |
2005年 | 16篇 |
2004年 | 14篇 |
2003年 | 11篇 |
2002年 | 12篇 |
2001年 | 12篇 |
2000年 | 19篇 |
1999年 | 11篇 |
1998年 | 7篇 |
1997年 | 5篇 |
1996年 | 4篇 |
1995年 | 2篇 |
1994年 | 4篇 |
1992年 | 1篇 |
1991年 | 4篇 |
1990年 | 2篇 |
1989年 | 6篇 |
1988年 | 1篇 |
1987年 | 2篇 |
1986年 | 4篇 |
1985年 | 1篇 |
1984年 | 2篇 |
1983年 | 2篇 |
1980年 | 1篇 |
1978年 | 3篇 |
1977年 | 3篇 |
1973年 | 1篇 |
排序方式: 共有244条查询结果,搜索用时 0 毫秒
1.
2.
Kazuhiko Yasuml Rong-Jun Guo Hiroyuki Hanai Hajime Arai Eizo Kaneko Hiroyuki Konno Selichi Takenoshita Koichi Hagiwara Haruhiko Sugimura 《Pathology international》1998,48(2):134-137
A new mutation in the serine-threonine klnase domain of the transforming growth factor β type II receptor (TGFpRII) was found in a case of diffuse, B cell non-Hodgkin's lymphoma of the stomach. A mfssense mutation (ACA to GCA, Thr to Ala) was detected In exon 5, and a wild type allele was also present. This Is the first naturally occurring mutation in the klnase domain of this gene identified in human primary lymphoma. The replication error at three loci was negative, and the poly A tract of exon 3, which is frequently a target of mismatch repair genes, was intact. Malignant lymphoma of B cell origin in the stomach Is an addition to an expanding catalogue of tumors with TGFβRII alterations, and the biological sequelae of the change in the functional domain and the clinical characteristics of the patient in this study are intriguing. 相似文献
3.
4.
Guo RJ; Wang Y; Kaneko E; Wang DY; Arai H; Hanai H; Takenoshita S; Hagiwara K; Harris CC; Sugimura H 《Carcinogenesis》1998,19(9):1539-1544
Mutations in the transforming growth factor beta type II receptor
(TGFbetaRII) gene have been detected in several human cancer types
exhibiting microsatellite instability. Using intron primers previously
reported for examination of the entire coding region of the TGFbetaRII
gene, 29 sporadic gastric cancers were screened with non-radioactive single
strand conformation polymorphism and subsequent DNA sequencing analysis.
Mutations of the TGFbetaRII gene were detected in three out of 29 tumors
(10%). Two cases showed deletions in a polyadenine tract in both alleles
and was positively associated with replication error. One case had an
insertion of GA dinucleotide sequence in one allele. Mutations of the
TGFbetaRII gene were restricted to exon 3 and other coding regions were not
affected. Loss of heterozygosity was detected by analyzing a polymorphic
site in intron 2. Three out of nine (33%) informative cases, which were all
of intestinal type and advanced cases, showed loss of heterozygosity but
neither TGFbetaRII mutation nor replication error was found in these cases.
Immunoreactivity of TGFbetaRII in tumor tissues was reduced to a different
extent in the gastric cancer with genetically abnormal transforming growth
factor. Although the numbers studied are small, homozygous (A)10 deletion
or loss of heterozygosity of TGFbetaRII is involved in tumorigenesis and
progression of at least some part of sporadic gastric cancer.
相似文献
5.
Erito Mochiki Hideki Suzuki Seiichi Takenoshita Yukio Nagamachi Hiroyuki Kuwano Akiyoshi Mizumoto Zen Itoh 《Journal of gastroenterology》1998,33(6):835-841
Glucagon is commonly used during gastrointestinal examinations for the temporary inhibition of gastroduodenal movements.
Three preparations of glucagon are now clinically available: those prepared by extraction from the pancreas (GL-P), by chemical
synthesis (GL-S), and by genetic recombination (GL-G). The aim of this study was examine the mechanism of the inhibitory effect
of glucagon on gastrointestinal motility and the cause of its side effects by comparing three glucagon preparations. In four
conscious dogs, gastrointestinal contractions were monitored by means of chronically implanted force transducers. Each glucagon
preparation (GL-P [15 μg/kg], GL-S [5, 15, 45 μg/kg], GL-G [15 μg/kg]), scopolamine butylbromide (0.4 mg/kg), or saline was
administered intravenously 20 min after the termination of spontaneous phase III contractions, and blood samples were taken
at 5- to 10-min intervals. Barium was administered into the stomach 10 min after the infusion of each drug. The arrival of
a barium meal in the stomach immediately stimulated gastrointestinal contractions, and the barium meal was expelled into the
duodenum and jejunum from the stomach. Intravenous injection of 15 μg GL-S first stimulated duodenal contractions that propagated
to the jejunum, followed by strong inhibition of the barium-induced gastrointestinal contractions. This inhibitory effect
of glucagon and the activity of the glucagon-induced duodenal contractions were dose-related. The inhibitory effects of GL-G
and GL-S were stronger than that of GL-P. Blood glucose and plasma insulin concentrations were raised after intravenous injection
of each glucagon preparation, but there was no difference among the three preparations and no dose relationship. The inhibitory
effects of glucagon depend on the material purity and dose, and the inhibitory mechanism was independent of any effect on
carbohydrate metabolism. Glucagon administration caused phase III-like contractions in the duodenum and jejunum, which may
be responsible for the side effects of glucagon.
(Received Jan. 8, 1998; accepted June 26, 1998) 相似文献
6.
7.
Yojiro Umezaki Ayano Katagiri Motoko Watanabe Miho Takenoshita Tomomi Sakuma Emi Sako Yusuke Sato Akira Toriihara Akihito Uezato Hitoshi Shibuya Toru Nishikawa Haruhiko Motomura Akira Toyofuku 《European archives of psychiatry and clinical neuroscience》2013,263(4):315-323
Oral cenesthopathy is a somatic delusion or hallucination involving the oral area and is categorized as a delusional disorder, somatic type. The pathophysiology of this intractable condition remains obscure. In this study, we clarified the pathophysiology of oral cenesthopathy by evaluating regional brain perfusion. We performed single photon emission computed tomography (SPECT) using 99mTc-ethylcysteinate dimer in 16 subjects (cenesthopathy:control = 8:8). The SPECT images were visually assessed qualitatively, and quantitative analyses were also performed using a three-dimensional stereotactic region-of-interest template. The visual assessment revealed a right > left perfusion asymmetry in broad areas of the brain among the patients. The quantitative analysis confirmed that the regional cerebral blood flow values on the right side were significantly larger than those on the left side for most areas of the brain in the patients. A comparison of the R/(R + L) ratios in both groups confirmed the significant brain perfusion asymmetry between the two sides in the callosomarginal, precentral, and temporal regions in the patients. Qualitative evaluation of the SPECT images revealed right > left brain perfusion asymmetry in broad regions of the brain. Moreover, the quantitative analyses confirmed the perfusion asymmetry between the two sides in the frontal and temporal areas. Those may provide the key for elucidation of the pathophysiology of oral cenesthopathy. 相似文献
8.
Tomoko Miki Osamu Yokota Takashi Haraguchi Hideki Ishizu Masato Hasegawa Takeshi Ishihara Shu‐ichi Ueno Shintaro Takenoshita Seishi Terada Norihito Yamada 《Brain pathology (Zurich, Switzerland)》2020,30(4):811-830
Granular/fuzzy astrocytes (GFAs), a subtype of “aging‐related tau astrogliopathy,” are noted in cases bearing various neurodegenerative diseases. However, the pathogenic significance of GFAs remains unclear. We immunohistochemically examined the frontal cortex, caudate nucleus, putamen and amygdala in 105 cases composed of argyrophilic grain disease cases (AGD, N = 26), and progressive supranuclear palsy (PSP, N = 10), Alzheimer’s disease (AD, N = 20) and primary age‐related tauopathy cases (PART, N = 18) lacking AGD, as well as 31 cases bearing other various neurodegenerative diseases to clarify (i) the distribution patterns of GFAs in AGD, and PSP, AD and PART lacking AGD, (ii) the impacts of major pathological factors and age on GFA formation and (iii) immunohistochemical features useful to understand the formation process of GFAs. In AGD cases, GFAs consistently occurred in the amygdala (100%), followed by the putamen (69.2%) and caudate nucleus and frontal cortex (57.7%, respectively). In PSP cases without AGD, GFAs were almost consistently noted in all regions examined (90–100%). In AD cases without AGD, GFAs were less frequent, developing preferably in the putamen (35.0%) and caudate nucleus (30.0%). PART cases without AGD had GFAs most frequently in the amygdala (35.3%), being more similar to AGD than to AD cases. Ordered logistic regression analyses using all cases demonstrated that the strongest independent factor of GFA formation in the frontal cortex and striatum was the diagnosis of PSP, while that in the amygdala was AGD. The age was not significantly associated with GFA formation in any region. In GFAs in AGD cases, phosphorylation and conformational change of tau, Gallyas‐positive glial threads indistinguishable from those in tufted astrocytes, and the activation of autophagy occurred sequentially. Given these findings, AGD, PSP, AD and PART cases may show distinct distributions of GFAs, which may provide clues to predict the underlying processes of primary tauopathies. 相似文献
9.