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排序方式: 共有333条查询结果,搜索用时 15 毫秒
1.
L. N. Grushevskaya B. M. Pyatin O. B. Stepanenko N. I. Avdyunina V. P. Lezina V. I. Prokof’eva 《Pharmaceutical Chemistry Journal》2007,41(8):440-443
Cardiocyclide, a new Russian class III antiarrhythmic agent, was developed at the State V. V. Zakusov Science Research Institute
Pharmacology, Russian Academy of Medical Sciences. The aims of the present work were to study the physicochemical properties
of the hydrochloride salt of this agent (N1-(3-diethylaminopropyl)-N1-(p-nitrobenzoyl)aminoacetic acid N,N-dicyclohexylamide HCl) and to develop an analytical method for this compound. IR, 1H NMR, and UV spectra were obtained for cardiocyclide; its solubility was studied; its melting temperature, weight loss on
drying and the transparency, color, and pH of its solutions were determined. The purity of material containing compound I
was determined by thin-layer chromatography; quantitative cardiocyclide contents were estimated by non-aqueous titration.
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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 41, No. 8, pp. 42–45, August, 2007. 相似文献
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S. E. Milkina O. B. Stepanenko L. N. Grushevskaya N. I. Avdyunina B. M. Pyatin V. L. Bagirova E. B. Nechaeva 《Pharmaceutical Chemistry Journal》2006,40(7):405-406
The physicochemical properties of the new anxiolytic drug afobazole, which belongs to the group of 2-mercaptobenzimidazole
derivatives, have been studied with a view to its pharmacopoeial standardization. It is suggested to check afobazole for the
presence of impurities by means of TLC and HPLC. Methods for the standardization of afobazole are developed and a project
for the pharmacopoeial article of manufacturer for this drug is formulated.
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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 40, No. 7, pp. 55–56, July, 2006. 相似文献
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Cyclic peptide disulfides of the general formula were synthesized from the corresponding peptide derivatives [Boc-Cys(Trt)(Gly)-n-Cys(Trt)-OBut] by oxidation with iodine in methanol and by subsequent removal of the terminal groups with trifluoroacetic acid. Acid ionization constants of the obtained peptides were determined by potentiometric titration in aqueous KCl (0.1 mol/L) medium. All compounds have two dissociable hydrogens, corresponding to carboxyl (pK1= 2.35–2.84) and to terminal amino group (pK2= 5.61–6.93); pK1, values show first an upward and then a downward trend with the increase in ring size; the opposite is true for pK2, values. These trends could be tentatively attributed to the intramolecular salt bridge (-COO——-NH+3-) formation. 相似文献
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John L. Butler VI MS 《Journal of family psychotherapy》2013,24(1):87-88
No abstract available for this article. 相似文献
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Antonio Loforte Alexander Stepanenko Evgenij V. Potapov Francesco Musumeci Nikolay Dranishnikov Martin Schweiger Andrea Montalto Miralem Pasic Yuguo Weng Michael Dandel Henryk Siniawski Marian Kukucka Thomas Krabatsch Roland Hetzer 《Artificial organs》2013,37(6):523-530
Early planned institution of temporary right ventricular assist device (RVAD) support with the CentriMag (Levitronix LLC, Waltham, MA, USA) in left ventricular assist device (LVAD) recipients was compared with permanent biventricular assist device (BVAD) or total artificial heart (TAH) support. Between 2007 and 2011, 77 patients (age range: 25–70 years) with preoperative evidence of biventricular dysfunction (University of Pennsylvania score >50; University of Michigan score >5) were included. Forty‐six patients (38 men; median age 54.5 years, range: 25–70 years) underwent LVAD placement combined with temporary RVAD support (group A); in 31 patients (25 men; median age 56.7 years, range: 28–68 years), a permanent BVAD or TAH implantation (group B) was performed. Within 30 days, 12 patients from group A (26.08%) and 14 patients from group B (45.1%) died on mechanical support (P = 0.02). Thirty patients (65.2%) in group A were weaned from temporary RVAD support and three (6.5%) underwent permanent RVAD (HeartWare, Inc., Framingham, MA, USA) placement. A total of 26 patients (56.5%) were discharged home in group A versus 17 (54.8%) in group B (P = 0.56). Three patients (8.5%) received heart transplantation in group A and six (19.3%) in group B (P = 0.04). In group A, 90‐day and 6‐month survival was 54.3% (n = 25) versus 51.6% (n = 16) in group B (P = 0.66). In group A, 1‐year survival was 45.6% (n = 21) versus 45.1% (n = 14) in group B (P = 0.81). The strategy of planned temporary RVAD support in LVAD recipients showed encouraging results if compared with those of a similar permanent BVAD/TAH population. Weaning from and removal of the temporary RVAD support may allow patients to be on LVAD support only despite preoperative biventricular dysfunction. 相似文献
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