排序方式: 共有18条查询结果,搜索用时 15 毫秒
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Sven Voss Wadha Abushreeda Ariadni Vonaparti Aisha Al-Wahaibi Noora Al-Sowaidi Ibrahim Al-Mohannadi Souhila Mahieddine Safa Khelifi Sofia Salama Amal Saleh Maryam Al-Mohannadi Wesal El-Saftawy Khalifa Al-Hamad Ahmad Nofal Najib Dbes Rodrigo Aguilera Mohammed Al Maadheed Costas Georgakopoulos 《Drug testing and analysis》2021,13(2):460-465
The current study examined the stability of several antidoping prohibited substances analytes in urine after 15-min exposure to UV-C light in a Biosafety Level 2 cabinet. The urine matrices were exposed within the original antidoping bottles with the aim to destroy DNA/RNA and possible SARS CoV-2. The analytes small molecules Phase I and Phase II metabolites and peptides, in total 444, endogenous, internal standards, and prohibited substances, pH, and specific gravity in urine were studied. The accredited analytical methods were used by Anti-Doping Laboratory Qatar for the comparison of data of the same urine samples analyzed with and without UV-C exposure. In the study conditions, no problems of stability were detected in the substances spiked in the urine samples exposed in the UV-C irradiation. 相似文献
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Descamps D Assoumou L Masquelier B Marcelin AG Saidi S Tamalet C Cottalorda J Plantier JC Montes B Izopet J Peytavin G Yerly S Schneider V Delaugerre C Ferré V Ruffault A Pallier C Morand-Joubert L Chaix ML Calvez V Brun-Vézinet F Costagliola D;ANRS AC- Resistance Study Group 《The Journal of antimicrobial chemotherapy》2008,62(3):451-455
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hSNF5/INI1, which encodes a component of the ATP-dependent chromatin remodeling hSWI-SNF complex, is a tumor suppressor gene mutated in malignant rhabdoid tumors. We have developed a tetracycline-based hSNF5/INI1-inducible system in a hSNF5/INI1-deficient malignant rhabdoid tumor cell line and studied time course variation of 22,000 genes/expressed sequence tags upon hSNF5/INI1 induction. A total of 482 responsive genes were identified and further clustered into 9 groups of coregulated genes. Among genes with early and strong inductions, the use of a fusion protein with the hormone-binding domain of the estrogen receptor enabled the identification of a subset of direct targets regulated independently of de novo protein synthesis. We show that the G(1) arrest induced by hSNF5/INI1 is reversible and associated with the down-regulation of components of the DNA replication complex. We also identify an unsuspected role of hSNF5/INI1 in cytoskeleton organization. Indeed, induction of hSNF5/INI1 induces dramatic modifications of the cell shape including complete disruption of the actin stress fiber network and disappearance of focal adhesions associated with up-regulation of genes involved in the organization of the actin cytoskeleton. We document a strong decrease of Rho activity upon hSNF5/INI1 expression, suggesting that the regulation of this activity constitutes a crucial step of the hSNF5/INI1-induced reorganization of the actin network. This study identifies hSNF5/INI1 target genes and provides evidence that hSNF5/INI1 may modulate the cell cycle control and cytoskeleton organization through the regulation of the retinoblastoma protein-E2F and Rho pathways. 相似文献
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Laurent Garderet Frederique Kuhnowski Benoit Berge Murielle Roussel Laure Devlamynck Marie Odile Petillon Martine Escoffre-Barbe Ingrid Lafon Thierry Facon Xavier Leleu Lionel Karlin Aurore Perrot Anne-Marie Stoppa Bruno Royer Carine Chaleteix Mourad Tiab Carla Araujo Pascal Lenain Margaret Macro Karim Belhadj Souhila Ikhlef Cyrille Hulin Herve Avet Loiseau Michel Attal Philippe Moreau 《British journal of haematology》2023,201(6):1103-1115
Lenalidomide maintenance in myeloma is well established. Nevertheless, pomalidomide could provide an alternative. Myeloma patients in first relapse, initially treated in the Intergroupe Francophone du Myélome (IFM) 2009 trial, and subsequently in the IFM 2013-01 phase 2 trial, received four cycles of salvage therapy with pomalidomide plus cyclophosphamide plus dexamethasone (PCD) with transplantation plus 2 PCD consolidation or without transplantation but with 5 PCD and for all patients pomalidomide plus dexamethasone maintenance therapy. This consisted of 28-day cycles of pomalidomide 4 mg daily on days 1–21 and dexamethasone 20 mg weekly until progression. The primary endpoint was an improved response to treatment. A total of 75/100 patients reached therapy. The median follow-up time was 73 months. The median duration of treatment was 23.7 months. One third of patients improved their response from the initiation of treatment: 11%, 19% and 4% to a very good partial response, complete response or stringent complete response respectively. The median progression-free survival time was 33.2 months and the median overall survival time was not reached. Among the 75 patients, the reasons for pomalidomide discontinuation were progressive disease (54%), adverse events (AEs) (30%), investigator discretion (11%) and consent withdrawal (5%). Grade (G) 3/4 haematological AEs included neutropenia (51%) and lymphopenia (35%); G3/4 drug-related non-haematological AEs (>5%) comprised 13% infections. Long-term administration of pomalidomide and dexamethasone is feasible and one third of the patients improved their response. 相似文献
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Hayashi D Tkacz JN Hammond S Devenney-Cakir BC Zaim S Bouzegaou N Ounadjela S Guermazi A 《Japanese journal of radiology》2011,29(2):85-91
Neuroendocrine tumors of the gastrointestinal tract are rare entities. Functioning neuroendocrine tumors tend to present early
because of hormoneinduced clinical symptoms, but detection of the primary lesion may be difficult owing to their small size.
Neuroendocrine tumors are typically hypervascular and show enhancement after contrast administration on computed tomography
(CT) or magnetic resonance imaging (MRI). Large nonfunctioning tumors may be found in asymptomatic patients. In such cases,
the synchronous presence of hypervascular hepatic metastases should be explored. This pictorial review illustrates imaging
features of functioning and nonfunctioning neuroendocrine tumors arising in the gastrointestinal tract and the pancreas. Modalities
included are CT, MRI, ultrasonography, and nuclear medicine. Characteristic histological specimens of these lesions are presented. 相似文献
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Hassen Iabadene Yamina Messai Houria Ammari Souhila Alouache Charlotte Verdet Rabah Bakour Guillaume Arlet 《International journal of antimicrobial agents》2009,34(4):340-342
The aim of this study was to investigate the prevalence and diversity of plasmid-mediated AmpC cephalosporinases (PAcBLs) in clinical isolates of Enterobacteriaceae collected between 2003 and 2007 from three Algiers hospitals. Antibiograms were determined on Mueller–Hinton agar plates using the disk diffusion method, and minimum inhibitory concentrations were determined by Etest. Isolates resistant to cefoxitin or ceftazidime were screened for blaCMY, blaDHA, blaFOX and blaACC as well as extended-spectrum β-lactamase (ESBL) genes by polymerase chain reaction (PCR). PCR products were sequenced by the Sanger method. Plasmid incompatibility grouping was conducted by PCR-based replicon typing. The prevalence of PAcBLs was 2.18% (11/505), comprising 8 CMY-2 and 3 DHA-1 enzymes. CTX-M-15 was co-produced with CMY-2 in three isolates and with DHA-1 in one isolate; the two remaining DHA-1-producers co-expressed SHV-12 ESBL. This is the first report of plasmid-mediated AmpC from Algeria, with the first detection of DHA-1 in Enterobacter cloacae. 相似文献