全文获取类型
收费全文 | 1707篇 |
免费 | 83篇 |
国内免费 | 11篇 |
专业分类
耳鼻咽喉 | 34篇 |
儿科学 | 47篇 |
妇产科学 | 21篇 |
基础医学 | 184篇 |
口腔科学 | 28篇 |
临床医学 | 108篇 |
内科学 | 484篇 |
皮肤病学 | 16篇 |
神经病学 | 117篇 |
特种医学 | 64篇 |
外科学 | 259篇 |
综合类 | 11篇 |
预防医学 | 71篇 |
眼科学 | 32篇 |
药学 | 135篇 |
中国医学 | 7篇 |
肿瘤学 | 183篇 |
出版年
2022年 | 23篇 |
2021年 | 35篇 |
2020年 | 21篇 |
2019年 | 19篇 |
2018年 | 27篇 |
2017年 | 24篇 |
2016年 | 27篇 |
2015年 | 24篇 |
2014年 | 38篇 |
2013年 | 40篇 |
2012年 | 84篇 |
2011年 | 94篇 |
2010年 | 55篇 |
2009年 | 49篇 |
2008年 | 70篇 |
2007年 | 70篇 |
2006年 | 80篇 |
2005年 | 72篇 |
2004年 | 81篇 |
2003年 | 61篇 |
2002年 | 53篇 |
2001年 | 64篇 |
2000年 | 62篇 |
1999年 | 53篇 |
1998年 | 14篇 |
1997年 | 16篇 |
1996年 | 15篇 |
1995年 | 17篇 |
1994年 | 21篇 |
1993年 | 18篇 |
1992年 | 43篇 |
1991年 | 40篇 |
1990年 | 50篇 |
1989年 | 34篇 |
1988年 | 42篇 |
1987年 | 30篇 |
1986年 | 34篇 |
1985年 | 29篇 |
1984年 | 17篇 |
1983年 | 16篇 |
1982年 | 7篇 |
1980年 | 7篇 |
1979年 | 14篇 |
1978年 | 7篇 |
1973年 | 8篇 |
1972年 | 7篇 |
1969年 | 12篇 |
1968年 | 9篇 |
1967年 | 10篇 |
1966年 | 12篇 |
排序方式: 共有1801条查询结果,搜索用时 15 毫秒
1.
Heterozygous nonsense mutations near the C‐terminal region of IGF1R in two patients with small‐for‐gestational‐age‐related short stature
下载免费PDF全文
![点击此处可从《Clinical endocrinology》网站下载免费的PDF全文](/ch/ext_images/free.gif)
2.
Patricia A Wilkosz Sachiko Miyahara Oscar L Lopez Steven T Dekosky Robert A Sweet 《The American journal of geriatric psychiatry》2006,14(4):352-360
BACKGROUND: Psychotic symptoms in Alzheimer disease (AD+P) identify a heritable phenotype associated with more rapid cognitive decline. The authors have proposed that AD+P is itself a composite of a misidentification and a paranoid subtype with increased cognitive impairment restricted to the misidentification type. Most prior studies of the clinical correlates of AD+P have been limited, however, by the inclusion of prevalent cases. METHODS: Subjects with possible or probable AD or mild cognitive impairment (MCI) without psychosis at study entry were assessed at the time of initial presentation and then annually. Psychotic symptoms were assessed using the CERAD Behavioral Rating Scale. Survival analyses used Cox proportional hazard models with time-dependent covariates to examine the predictors of psychosis onset. RESULTS: A total of 288 subjects completed at least one follow-up examination. Mean duration of follow-up was 22.1 months. The incidence of psychosis was 0.19 per person-year. Cognitive impairment was associated with onset of psychosis, largely as a result of its association with onset of the misidentification, but not the paranoid, subtype. Including psychotropic medication use in the model revealed an association of antidepressant use with the onset of psychosis. This latter association appeared to arise from an underlying association between depression and the risk of psychosis onset rather than from antidepressant treatment. CONCLUSION: These findings are consistent with the hypothesis that the misidentification and the paranoid subtypes each define a more biologically homogeneous group than AD+P as a whole. Further exploration of the relationship between depressive symptoms and psychosis in patients with AD is warranted. 相似文献
3.
Endoscopic anterior cruciate ligament reconstruction using a computer-assisted fluoroscopic navigation system 总被引:3,自引:0,他引:3
Hisatada Hiraoka Sou Kuribayashi Akira Fukuda Naoshi Fukui Kozo Nakamura 《Journal of orthopaedic science》2006,11(2):159-166
Background During anterior cruciate ligament (ACL) reconstruction, placement of the reconstructed ligament affects the clinical results.
To accomplish accurate and reproducible placement of the tibial bone tunnel, we employed a fluoroscopic navigation system
for endoscopic ACL reconstruction. In this study, preciseness of the tibial tunnel placement was evaluated, and the advantages
and disadvantages of this navigation system for endoscopic ACL reconstruction are discussed.
Methods Altogether, 16 knees of 16 patients who had undergone ACL reconstruction using this system (navi group) were evaluated regarding
the positioning of the tibial tunnel against Blumensaat's line using X-p and the route of the graft by magnetic resonance
imaging (MRI). Another 16 knees of 16 patients who underwent endoscopic ACL reconstruction without the navigation system were
the controls (control group).
Results At the 1-year follow-up, maximally extended lateral knee X-p revealed that the anterior edge of the tibial tunnel and Blumensaat's
line were almost aligned and that roof impingement was avoided; the T2-weighted MR images showed that the graft was placed
close to and parallel to the intercondylar roof in all the knees of the navi group. The ratio of the distance between Blumensaat's
line and the anterior edge of the tibial tunnel at the level of the tibial plateau to the anteroposterior width in fully extended
true lateral radiographs was 2.7% ± 3.4% in the navi group and 8.4% ± 7.4% in the control group.
Conclusions The computer-assisted fluoroscopic navigation system improves accuracy and decreases dispersion of the tibial tunnel placement
against Blumensaat's line in single-bundle ACL reconstruction. This innovative device renders the reconstruction procedure
more reliable, eliminating the problem of skeletal variation among patients. However, the function of this navigation system
for femoral tunnel placement is insufficient at present. Further refinement of the system is necessary, and the method of
application requires improvement. 相似文献
4.
5.
N Mihara T Hachisuga S Yamasaki K Fukuda G Iwasaka H Sugimori S Miyahara 《Gan no rinsho》1987,33(15):1939-1944
A rare case of malignant peritoneal mesothelioma in a 49-year-old Japanese woman is presented. The tumor was limited to the peritoneum, and was cytologically and histologically identified as being composed of two components, epithelial and non-epithelial forms. The transition in her CA-125 level suggested that this tumor had good prospects of developing into a malignant mesothelioma. The good prognosis of the patient is considered to be attributed to detecting this tumor in its early stage and to aggressive chemotherapy. 相似文献
6.
Serum lipid and apolipoprotein concentrations were measured in 37 male survivors of cerebral infarction (CI) and in 30 healthy controls. Both groups had similar total cholesterol levels, but the HDL-cholesterol level was significantly lower and the serum triglyceride level was significantly higher in the CI patients than in the controls. The ApoB level was significantly higher in the CI patients but there was no significant difference between the 2 groups in the levels of the other apolipoproteins (ApoA-I, A-II, C-II, C-III, and E). The HDL-cholesterol/ApoA-I ratio was significantly lower in the CI patients. Both the VLDL-triglyceride and VLDL-cholesterol levels were higher in the CI patients but the VLDL-cholesterol especially its cholesterol ester level was conspicuously high. A population of VLDL particles that bound to heparin on heparin-Sepharose columns was increased in the CI patients. We suggest that cholesterol ester is excessively transferred from HDL to VLDL during the disturbed catabolism of VLDL in CI patients. 相似文献
7.
Hiroomi Murayama Masanobu Meda Ken Miyahara Yoshimasa Sakai Hajime Sakurai Hiroki Hasegawa Akemi Kawamura 《The Japanese Journal of Thoracic and Cardiovascular Surgery》2003,51(3):91-97
Objective: We assessed the current role of preoperative and intraoperative autologous blood donation in pediatric open-heart surgery.
Methods: Group 1 consisted of 51 patients between 5 and 10 years old who underwent preoperative autologous blood donation. Group
2 consisted of 50 age-matched patients without preoperative donation as controls. Intraoperative donation was conducted in
both groups prior to cardiopulmonary bypass. We evaluated perioperative blood cell count, blood loss, and the need for homologous
blood products. Results: No serious complications occurred in preoperative or intraoperative donation. Total preoperative donation storage was 17.5±3.4
mL/kg. Intraoperative donation was 21.7 ±6.1 mL/kg in Group 1 and 12.8±4.0 mL/kg in Group 2 (p<0.001). On admission, serum
hemoglobin was lower in Group 1 (12.2±1.0 g/dL versus 13.6±1.6 g/dL, p<0.001) but returned postoperatively to the preoperative
value. It hovered at a depressed level in Group 2 (12.2±1.4 versus 10.2±1.1 g/dL, p<0.001). The homologous blood requirement
was significantly less in Group 1 than in Group 2 (0% versus 10%, p<0.05). Postoperative platelet counts showed similar curves,
and blood loss was not statistically significantly different between groups. Conclusion: Preoperative and intraoperative donations are safe and continue to contribute uniquely to blood conservation, providing
important options in comprehensive blood conservation programs in current pediatric open-heart surgery. 相似文献
8.
Masayuki Imamura Yutaka Shimada Yuhji Kanda Manabu Fukumoto Ken Yanagibashi Tokiharu Miyahara Takayoshi Tobe 《Surgery today》1992,22(5):409-415
In order to decrease the perioperative complications by preoperative cisplatin chemotherapy, the preoperative single administration of cisplatin (30 mg/m2) was performed weekly from one to six times in 36 consecutive patients with esophageal cancer classified as higher than Stage II. The survival curve of 17 patients in Stage III was significantly better (P<0.05) than that of patients who had been treated without preoperative cisplatin treatment. In 3 of the 12 patients who had locally invasive cancer, either the main tumors or the metastatic lymph nodes, which had invaded the trachea or the left main bronchus, sufficiently receded, so that a curative esophagectomy became possible; 2 of them have survived over 33 months while 1 died of pneumonia 33 months after surgery. The number of perioperative complications was minimal, and thus, we consider that the postoperative use of cisplatin and fluorouracil is indicated in patients in whom a histological response is noted in the resected specimens.This work was partially supported by Grant No. 02454315 from the Japanese Ministry of Education 相似文献
9.
10.