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Knowing good from bad: differential activation of human cortical areas by positive and negative outcomes 总被引:10,自引:0,他引:10
Nieuwenhuis S Slagter HA von Geusau NJ Heslenfeld DJ Holroyd CB 《The European journal of neuroscience》2005,21(11):3161-3168
Previous research has identified a component of the event-related brain potential (ERP), the feedback-related negativity, that is elicited by feedback stimuli associated with unfavourable outcomes. In the present research we used event-related functional magnetic resonance imaging (fMRI) and electroencephalographic (EEG) recordings to test the common hypothesis that this component is generated in the caudal anterior cingulate cortex. The EEG results indicated that our paradigm, a time estimation task with trial-to-trial performance feedback, elicited a large feedback-related negativity (FRN). Nevertheless, the fMRI results did not reveal any area in the caudal anterior cingulate cortex that was differentially activated by positive and negative performance feedback, casting doubt on the notion that the FRN is generated in this brain region. In contrast, we found a number of brain areas outside the posterior medial frontal cortex that were activated more strongly by positive feedback than by negative feedback. These included areas in the rostral anterior cingulate cortex, posterior cingulate cortex, right superior frontal gyrus, and striatum. An anatomically constrained source model assuming equivalent dipole generators in the rostral anterior cingulate, posterior cingulate, and right superior frontal gyrus produced a simulated scalp distribution that corresponded closely to the observed scalp distribution of the FRN. These results support a new hypothesis regarding the neural generators of the FRN, and have important implications for the use of this component as an electrophysiological index of performance monitoring and reward processing. 相似文献
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Talsma D Slagter HA Nieuwenhuis S Hage J Kok A 《Brain research. Cognitive brain research》2005,25(1):117-129
This study investigated the electrophysiological correlates of shifting, maintaining, and relaxing the focus of attention, using a symbolic cuing task. Cues and imperative stimuli were presented in rapid succession, and the ADJAR procedure was used to remove the contribution of event-related potential (ERP) activity associated with the imperative stimulus from the cue-related ERP waveforms. Initial analyses, comparing left and right attention-directing cues, replicated previous findings of early directing attention negativity (EDAN) and anterior directing attention negativity (ADAN) effects. To isolate ERP activity that is common to leftward and rightward attention shifts, the combined ERP activity elicited by attention-directing cues was compared to the ERP activity elicited by non-informative cues. This analysis revealed a strong and broadly distributed early positivity followed by a sustained central negativity, possibly reflecting the controlled orienting and subsequent maintenance of attentional focus. Finally, imperative stimuli preceded by non-informative cues were characterized by an enhanced posterior P2 effect, with a scalp distribution indicative of generators in visual areas. This result suggests a relatively late (re)activation in visual areas associated with the processing of stimuli that had not been cued in advance. 相似文献
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Functional anatomical correlates of controlled and automatic processing 总被引:11,自引:0,他引:11
Behavioral studies have shown that consistent practice of a cognitive task can increase the speed of performance and reduce variability of responses and error rate, reflecting a shift from controlled to automatic processing. This study examines how the shift from controlled to automatic processing changes brain activity. A verbal Sternberg task was used with continuously changing targets (novel task, NT) and with constant, practiced targets (practiced task, PT). NT and PT were presented in a blocked design and contrasted to a choice reaction time (RT) control task (CT) to isolate working memory (WM)-related activity. The three-dimensional (3-D) PRESTO functional magnetic resonance imaging (fMRI) sequence was used to measure hemodynamic responses. Behavioral data revealed that task processing became automated after practice, as responses were faster, less variable, and more accurate. This was accompanied specifically by a decrease in activation in regions related to WM (bilateral but predominantly left dorsolateral prefrontal cortex (DLPFC), right superior frontal cortex (SFC), and right frontopolar area) and the supplementary motor area. Results showed no evidence for a shift of foci of activity within or across regions of the brain. The findings have theoretical implications for understanding the functional anatomical substrates of automatic and controlled processing, indicating that these types of information processing have the same functional anatomical substrate, but differ in efficiency. In addition, there are practical implications for interpreting activity as a measure for task performance, such as in patient studies. Whereas reduced activity can reflect poor performance if a task is not sensitive to practice effects, it can reflect good performance if a task is sensitive to practice effects. 相似文献
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Lifestyle and clinical determinants of skin autofluorescence in a population‐based cohort study
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PURPOSE: To investigate the influence of (1) osteoporosis on resorption of edentulous and (2) whether osteoporosis enhances implant loss. MATERIALS AND METHODS: MEDLINE, EMBASE, and Cochrane Central Register of Controlled Trials (CENTRAL) databases were searched for association of osteoporosis and bone resorption/loss of implants. Inclusion and exclusion criteria were defined and quality assessment of the remaining studies after exclusion was performed. The Cochrane approach for cohort studies was applied. RESULTS: Methodologic assessment of the eligible publications using the Cochrane approach resulted in the inclusion of 11 publications in the final evaluation. Most studies dealt with the association between the extent of resorption or atrophy of edentulous jaws and the systemic (femoral, lumbar spine, metacarpal) bone mineral content (BMC) or bone mineral density (BMD) status. Four studies reported a significant association between the extent of resorption and the skeletal BMC and/or BMD. Four studies evaluated the effect of endosseous implants on mandibular BMC or BMD changes and the association between systematic BMD statuses and loss of implants. These studies revealed no association between systemic BMD status, mandibular BMD status, bone quality, and implant loss. CONCLUSIONS: Although no firm conclusions could be drawn regarding the effect of osteoporosis on resorption of edentulous jaws, with or without implants, due to the different parameters applied in the various studies, the use of endosseous implants in osteoporosis patients is not contraindicated. 相似文献
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Swallowing thresholds of mandibular implant-retained overdentures with variable portion sizes 总被引:1,自引:0,他引:1
Fontijn-Tekamp FA Slagter AP Van der Bilt A Van't Hof MA Kalk W Jansen JA 《Clinical oral implants research》2004,15(3):375-380
We analysed the effect of three portion sizes Optocal Plus (small, medium and large) on swallowing thresholds in subjects with either conventional complete dentures or mandibular implant-retained overdentures (transmandibular and permucosal cylindric implants). Tests were carried out in 52 women and 15 men (mean age 59 years) 4 years after treatment in a randomised controlled clinical trial. The results indicated that the degree of mucosal support for the mandibular denture did not affect the number of chewing strokes, time till swallowing or swallowed particle size. Only the chewing rate differed: subjects wearing mandibular implant-retained overdentures chewed the food at a higher rate than complete-denture wearers. With larger portion sizes, subjects needed significantly more chewing strokes and time until swallowing and they would have swallowed larger particles. Men chewed their food more efficiently than women, as they used the same number of chewing strokes and time, but achieved a greater particle size reduction at the swallowing moment. 相似文献