全文获取类型
收费全文 | 2312篇 |
免费 | 97篇 |
国内免费 | 16篇 |
专业分类
耳鼻咽喉 | 57篇 |
儿科学 | 174篇 |
妇产科学 | 109篇 |
基础医学 | 167篇 |
口腔科学 | 85篇 |
临床医学 | 198篇 |
内科学 | 372篇 |
皮肤病学 | 87篇 |
神经病学 | 248篇 |
特种医学 | 124篇 |
外科学 | 344篇 |
综合类 | 28篇 |
预防医学 | 75篇 |
眼科学 | 123篇 |
药学 | 132篇 |
中国医学 | 5篇 |
肿瘤学 | 97篇 |
出版年
2023年 | 21篇 |
2022年 | 31篇 |
2021年 | 62篇 |
2020年 | 43篇 |
2019年 | 63篇 |
2018年 | 65篇 |
2017年 | 54篇 |
2016年 | 83篇 |
2015年 | 87篇 |
2014年 | 94篇 |
2013年 | 135篇 |
2012年 | 171篇 |
2011年 | 156篇 |
2010年 | 114篇 |
2009年 | 84篇 |
2008年 | 163篇 |
2007年 | 200篇 |
2006年 | 175篇 |
2005年 | 169篇 |
2004年 | 120篇 |
2003年 | 112篇 |
2002年 | 79篇 |
2001年 | 28篇 |
2000年 | 21篇 |
1999年 | 20篇 |
1998年 | 13篇 |
1997年 | 4篇 |
1996年 | 5篇 |
1995年 | 5篇 |
1994年 | 3篇 |
1993年 | 1篇 |
1992年 | 4篇 |
1991年 | 4篇 |
1990年 | 7篇 |
1989年 | 8篇 |
1988年 | 1篇 |
1986年 | 4篇 |
1985年 | 3篇 |
1984年 | 1篇 |
1983年 | 2篇 |
1982年 | 2篇 |
1981年 | 1篇 |
1978年 | 2篇 |
1973年 | 1篇 |
1972年 | 1篇 |
1971年 | 2篇 |
1966年 | 1篇 |
排序方式: 共有2425条查询结果,搜索用时 15 毫秒
1.
Targeting in a cellular level is still one of the major challenges in biomedical treatments. However, new synthetic and analytical techniques now allow the development of precisely prepared macromolecules. Thus, glycopolymer chains are reported to be prepared with controlled length, monomer sequences, as well as chain‐folded structures. A high level of complexity in synthetic macromolecules also allows increased selectivity in targeting, which is a key factor in biomedical applications. 相似文献
2.
3.
C.T.-guided stereotactic destructive pain procedures; percutaneous cordotomy, trigeminal tractotomy-nucleotomy and extralemniscal myelotomy are presented. All procedures were applied in 32 cases without any mispuncture or complication. Advantages of C.T. guidance are direct visualization of target electrode relations, measurements of spinal cord diameters at the lesion site, and demonstration of spinal cord displacement during the procedure. 相似文献
4.
This study aimed to evaluate human antibody responses to diphtheria toxin subunits in various age groups. Antibodies against the intact diphtheria toxin and the diphtheria toxin subunits A and B were evaluated in 1319 individuals using a double-antigen ELISA. Although high levels of protection (83.6%, 95% CI 79.2-87.4) were found in children and adolescents, the middle-aged adult population was less protected (28.8%, 95% CI 24.3-33.6). An increase in age was associated with a decrease in the frequency of protected individuals in the 0-39-year age group (p <0.001). Anti-subunit B levels correlated well (p <0.01) with levels of antibodies against the intact toxin. In children aged < or =16 years, the intervals at which the peaks in geometric mean titres of anti-subunit B antibodies were observed were found to correlate with the ages at which booster doses are administered. Overall, males appeared to be more protected than females (OR 1.67, 95% CI 1.34-2.08, p <0.001). A small group of individuals had antibody levels of > or =0.1 IU/mL against the intact toxin, but did not have protective antibody against subunit B. Determination of anti-subunit B antibody levels should help in evaluating the effectiveness of diphtheria boosters and other aspects of diphtheria immunity. 相似文献
5.
Cemal Şenyuva Akın Yücel Yagmur Aydın Ihsan Okur Zeki Güzel 《Aesthetic plastic surgery》1997,21(4):233-239
Extracorporeal septoplasty is a radical solution for the severely deviated nose. The major problems associated with this
procedure are fixation of the septal cartilage graft and dorsal irregularities. Extracorporeal septoplasty was performed in
combination with open rhinoplasty in 17 patients with severe nasal deformities. In this technique septum was totally removed
through the columellar incision of open rhinoplasty, corrected outside, and replaced as a free ``L' shaped cartilage graft.
The cartilage graft was fixated to the upper lateral cartilages to restore the natural relations of the anatomical structures.
Additional rhinoplastic manipulations were also performed. The follow-up period was up to 18 months. The overall result was
successful in all patients. Nasal deviation did not recur and secondary revisions were not needed for any patient during follow-up. 相似文献
6.
Purpose: to determine wheather an association exists between sensorineural hearing loss and pseudoexfoliation. Methods: Hearing thresholds were determined by using pure-tone au-diometry in 75 patients with pseudoexfoliation syndrome and in the control group of 75 subjects without pseudoexfoliation The groups were sex and age matched. Results: The frequency of 相似文献
7.
Progressive motor syndrome in a welder with pallidal T1 hyperintensity on MRI: A two-year follow-up.
Chronic exposure to manganese (Mn) fume during welding may lead to mainly extrapyramidal syndrome that is resistant to treatment. We present a 32-year-old patient who developed severe postural instability, Parkinsonism, dystonia, and pyramidal signs in the 10th year of welding. The neurological condition of the patient worsened markedly in the following 3 years, resulting in severe disability rendering him to be assisted in all his daily activities and he did not benefit from any dopaminergic agent. T1 sequences of the MRI of the brain showed pallidal hyperintensity symmetrically. Welders in our country often protect their eyes but ignore to use tools that protect them from inhalation of the fume. Since chronic Mn toxicity may cause serious disability and irreversible neurological disturbances, we strongly believe that it is necessary to inform welders and their employers about this potential hazard. 相似文献
8.
Cavit Boz Mehmet Ozmenoglu Gonulden Aktoz Sibel Velioglu Zekeriya Alioglu 《Journal of clinical neuroscience》2004,11(5):523-525
We describe a patient who developed acute demyelinating polyneuropathy on the sixth week of interferon (IFN)alpha therapy for chronic hepatitis B (HBV) infection. A 23-year-old man with chronic HBV infection had acute onset of demyelinating polyneuropathy shortly after completing a standard 6-week course of therapy with IFNalpha 2a. Clinical findings, electrodiagnostic studies and elevated cerebrospinal fluid protein levels without cells supported the diagnosis of Guillain-Barré syndrome (GBS). Other potential causes of GBS were ruled out. It remains unknown whether IFNalpha or the HBV infection itself was the cause of GBS, but it is evident that IFNalpha could not have prevented the development of GBS in our patient. We suggest that coexistent HBV infection and IFNalpha therapy may play a role in triggering an autoimmune response to peripheral nerve myelin. 相似文献
9.
Hakan Gundes Bilgehan Tosun Sibel Gundes Alptekin Tosun Bahar Muezzinoglu 《European journal of orthopaedic surgery & traumatology : orthopedie traumatologie》2007,17(2):193-197
It is a common algorithm for hand surgeons to diagnose and treat persistent post-traumatic wrist pain as complex regional pain syndrome (CRPS). Although it works for many patients, some conditions that affect the wrist don’t fall in this category and worsen with this treatment practice. We present a single-handed patient who had had a non-displaced distal radius fracture and was treated as CRPS for the next three months. He was eventually diagnosed with late tuberculous tenosynovitis of the wrist and a total wrist arthrodesis was performed. We believe that Mycobacterium tuberculosis infection should be in the differential diagnosis of persistent post-traumatic joint pain. This is especially important as Mycobacterium infections are becoming more common due to an increase in patients with chronic immunosuppression and definitive diagnosis and treatment of tuberculous tenosynovitis needs a high index of clinical suspicion. 相似文献
10.
Subclinical adrenocortical insufficiency in renal amyloidosis 总被引:1,自引:0,他引:1
In order to investigate the functional significance of possible adrenal amyloid infiltration in patients with renal amyloidosis, we performed corticotrophin stimulation tests in 15 patients having renal amyloidosis with no clinical evidence of adrenocortical insufficiency and 12 controls. In 7 of the patients, the cortisol increments obtained during the test were found to be consistent with primary adrenal insufficiency due to possible amyloid infiltration of the adrenal cortex; in contrast, in all control subjects, adrenal responses to the test were regarded as sufficient for proper adrenal function. 相似文献