The treatment of acute cholecystitis

The authors treated 462 patients with acute cholecystitis. Operated on were 220 patients. Of them, 53.6%--at the first 24 hours after admission. In 26.3% of the patients, peritonitis was an indication for the operation. The postoperative lethality was 4.1%.     

The clinical importance of atrial fibrillation-flutter induced by electric transesophageal stimulation of the heart

A study was made of the clinical importance of atrial fibrillation-flutter (AFF) induced by using different modes of left atrium stimulation via the esophagus. Ninety-eight patients were entered into the study including 40 patients with a history of AFF paroxysms, 24 with risk factors of AFF development, and 27 practically normal persons. The stimulation modes applied permitted reproducing stable paroxysms of AFF in 85 percent of the patients with a history of arrhythmias and in none of the normal persons. As for the patients with risk factors, stable paroxysms of AFF could be induced in 33 percent of the cases. The specificity and sensitivity of transesophageal electrophysiologic stimulation (TEES) with the modes applied were 100 and 82 percent, respectively. The investigations have demonstrated that TEES appeared most effective when applied in the mode of an even increase of the frequency of the set pace up to 300 imp/min.     

Dual effects of endogenous DNases on transcriptionally active and inactive chromatin

Experiments on resting hepatocytes with inactive c-fos gene and active albumin gene. We revealed that DNA of the transcribed gene is less susceptible to the influence of endogenous Ca2+/Mg(2+)-dependent DNases in matrix-associated and highly soluble chromatin fractions. In the fraction of low soluble chromatin active gene was more accessible for DNases. Our results indicate that activity of endogenous DNases can change in the transcribed gene locus.     

Interaction between 16α,17α-cyclopropane progesterone and progesterone receptors in rat uterus

Binding of³H-16α, 17α-cyclopropanoprogesterone (CPG) and³H-progesterone (PG) to progesterone receptors in soluble fraction of rat uterus is studied. It is shown that CPG and PG specifically bind to the protein with similar affinity and binding capacity. Unlabeled PG competitively inhibits the binding of CPG, and unlabeled CPG competitively inhibits the binding of PF with the same efficiency. Dissociation of CPG- and PG-receptor complexes is characterized by the same dissociation constant. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 125, No. 5, pp. 532–534, May, 1998     

Anticoagulant Activity of Fucoidan from Brown Algae Fucus evanescens of the Okhotsk Sea

In vitro and in vivo experiments showed that anticoagulant activity of sulfated polysaccharide from Fucus evanescens (brown algae of the Okhotsk Sea) was similar to that of heparin. Anticoagulant properties of fucoidan are determined by thrombin inhibition mediated via plasma antithrombin III.     

Genetically determined diseases of the hip joint (a conceptual model)

The authors consider the problem of pathology of the hip joint from the point of view of the conception "Dysplasia-coxarthrosis". A single system of the ideas concerning dysplastis pathology is presented, which will allow to unify the methods of diagnosis and treatment of dysplasia of the hip joint in children, adolescents and adults with the aim of prevention of crippling diseases of the joint.     

Changes in the level of DNA minor bases in salivary gland inflammation and its correction with antioxidants

In the experiment with guinea pigs at contact sialoadenitis reproduction (karragenine inflammation of soft tissues of the oral cavity) it was established that in DNA of salivary glands cells and the neighbouring tissues the content of 5-methylcytosine was decreased, it being normalized at "Triovit" antioxidant complex together with cvercitynum correction. The content of DNA 8-hydroxyguanine is characterized by a wide range of data and in absolute values increases in inflammation, but decreases after antioxidant correction. The role of the changes discovered is discussed.