64层螺旋CT前瞻性与回顾性心电门控冠状动脉成像图像质量与辐射剂量比较的系统评价

目的对64层螺旋CT前瞻性心电门控与回顾性心电门控冠状动脉成像对照研究的文献进行Meta汇总分析,系统评价前瞻性心电门控的临床应用价值。方法通过电子检索中英文数据库(Medline、Pubmed、CNKI及万方数据库)和人工检索获取64层螺旋CT前瞻性心电门控与回顾性心电门控冠状动脉成像对照研究的文献。对符合条件的研究进行质量评估、异质性检验。计数资料及计量资料分别应用比值比及标准化差值作为效应量,根据异质性检验结果利用相符合的模型进行效应量合并。结果 64层螺旋CT前门控及后门控图像质量采用固定效应模型合并效应量(OR=1.10,95%CI=0.87～1.39)。认为前门控与后门控图像质量差异无统计学意义;64层螺旋CT前门控及后门控辐射剂量采用随机效应模型合并效应量[标准化均数差值(SMD)=-6.83,95%CI=-8.45～-5.22]。认为前门控与后门控图像质量差异有统计学意义。结论在低心率及心率变异的情况下,64层螺旋CT前瞻性心电门控冠状动脉成像同回顾性心电门控相比可以获得可用于诊断的图像质量,并且大幅减低辐射剂量。     

New treatment for peripheral nerve defects: Reconstruction of a 2 cm,monkey median nerve gap by direct lengthening of both nerve stumps

We have developed a new treatment for peripheral nerve defects: nerve‐lengthening method, and confirmed the efficacy and safety of our method using cynomolgus monkeys. A 20‐mm defect in the median nerve of monkey's forearms was repaired through the simultaneous lengthening of both nerve stumps with original nerve‐lengthening device. To evaluate nerve regeneration after neurorrhaphy, electrophysiological, histological, and functional recovery were examined and compared to the standard autografting. Nerve conduction velocity, axon maturation, and the result of functional test were superior in the nerve‐lengthening method than in the autografting. And there were no adverse events associated with our method. We concluded that this method is practical for clinical application. © 2011 Orthopaedic Research Society Published by Wiley Periodicals, Inc. J Orthop Res 30:153–161, 2012