Roentgeno-endovascular occlusion as a method of hemostasis in abdominal trauma

Under analysis is the authors' experience with roentgen-endovascular occlusions (REO) in 18 patients with closed injuries of the abdomen with massive hemorrhage. The embolization of spleen vessels was made in 8 patients, hepatic vessels--in 5 patients, renal vessels--in 3 patients and iliac artery branches--in 2 patients. In 10 cases REO was used as an independent method for arrest of hemorrhage and in 8 patients--for the preoperative preparation of the patients. The home hemostatic sponge was used in combination with superselective administration of the aminocaproic acid as the embolizing material.     

Protective effect of cyclopentyladenosine in a minimally invasive model of acute cerebral focal ischemia in rats

The neuroprotector properties of cyclopentyladenosine (CPA), an adenosine receptor agonist, were studied on a model of focal brain ischemia in rats (reproducing a clinical pathological process in humans). The model of the focal brain ischemia in rats was induced by intravasal occlusion of left carotid artery, middle cerebral artery, and by bilateral occlusion of both carotid arteries. CPA was introduced by intracerebroventricular injections in a dose of 25 micrograms/kg, 60 min before ischemia induction. The protective effect was judged by comparing the neurological and histopathological disturbances in the control (untreated ischemia) and on the CPA background. CPA injections produced a pronounced neuroprotector effect on the minimum-invasive focal brain ischemia model in rats.     

Emergency angiography in the diagnosis of nonpenetrating injuries of the abdominal organs

On the basis of 87 urgent angiographies in 65 patients the diagnosis of injuries of parenchymatous organs is described. The patients are divided into 4 groups: 1-contusion of the organ, 2-subcapsular and central hematomas, 3-transcapsular ruptures and fragmentation of the organ, 4-multiple injuries. Urgent angiography helps to make the exact diagnosis, to establish the character of injuries and to choose the method of treatment of the patients and the operation technique.     

Protective effect of A-agonists in a minimum invasive model of spinal cord ischemia in rats

The neuroprotective properties of N6-cyclohexyladenosine (CHA) and N6-cyclopentyladenosine (CPA), adenosine receptor agonists (A-agonists), were studied on a model of spinal cord ischemia (SCI) in rats (most closely reproducing the analogous clinical pathological process in humans). The SCI model was induced by intravasal occlusion of the abdominal aorta and its branches. CHA and CPA were introduced by intracerebroventricular injections in a dose of 25 micrograms/kg, 60 min before SCI induction. The protective effect was judged by comparing the patterns of neurological and histopathological disturbances in the untreated control (ischemia) and on the CHA or CPA background. The A-agonist CPA produced a pronounced, statistically reliable neuroprotector effect on the minimum invasive SCI model studied. CHA is also a statistically reliable but less effective neuroprotector. The A-agonists may have good prospects in clinics.