全文获取类型
收费全文 | 1899篇 |
免费 | 152篇 |
国内免费 | 8篇 |
专业分类
耳鼻咽喉 | 19篇 |
儿科学 | 78篇 |
妇产科学 | 23篇 |
基础医学 | 228篇 |
口腔科学 | 55篇 |
临床医学 | 305篇 |
内科学 | 416篇 |
皮肤病学 | 30篇 |
神经病学 | 101篇 |
特种医学 | 266篇 |
外科学 | 174篇 |
综合类 | 44篇 |
预防医学 | 122篇 |
眼科学 | 15篇 |
药学 | 96篇 |
中国医学 | 5篇 |
肿瘤学 | 82篇 |
出版年
2022年 | 13篇 |
2021年 | 22篇 |
2020年 | 13篇 |
2019年 | 25篇 |
2018年 | 36篇 |
2017年 | 21篇 |
2016年 | 31篇 |
2015年 | 41篇 |
2014年 | 50篇 |
2013年 | 64篇 |
2012年 | 66篇 |
2011年 | 63篇 |
2010年 | 58篇 |
2009年 | 70篇 |
2008年 | 59篇 |
2007年 | 53篇 |
2006年 | 66篇 |
2005年 | 42篇 |
2004年 | 45篇 |
2003年 | 53篇 |
2002年 | 42篇 |
2001年 | 47篇 |
2000年 | 53篇 |
1999年 | 30篇 |
1998年 | 59篇 |
1997年 | 66篇 |
1996年 | 71篇 |
1995年 | 58篇 |
1994年 | 60篇 |
1993年 | 55篇 |
1992年 | 32篇 |
1991年 | 25篇 |
1990年 | 33篇 |
1989年 | 53篇 |
1988年 | 49篇 |
1987年 | 51篇 |
1986年 | 59篇 |
1985年 | 49篇 |
1984年 | 34篇 |
1983年 | 21篇 |
1982年 | 31篇 |
1981年 | 20篇 |
1980年 | 13篇 |
1979年 | 16篇 |
1978年 | 17篇 |
1977年 | 20篇 |
1976年 | 13篇 |
1975年 | 20篇 |
1973年 | 12篇 |
1972年 | 10篇 |
排序方式: 共有2059条查询结果,搜索用时 31 毫秒
1.
G H Ballantyne M J Zdon D E Schafer G R Fratesi J R Roberts M Tyshkov I M Modlin 《Annals of surgery》1986,204(5):559-565
The cellular mechanisms by which pepsinogen (PNG) secretion is controlled are not understood. The aim of this study was to explore whether modulation of PNG secretion is mediated by cAMP or calcium-calmodulin (C-C). PNG secretion in isolated rabbit gastric fundic glands (IGG) was tested, using agents believed to act via cAMP or C-C. IGG were stimulated for 30 minutes with histamine (H) 10(-5) M, isoproterenol (I) 10(-5) M, carbachol (C) 10(-5) M, cholecystokinin-octapeptide (CCK-8) 10(-7) M, forskolin (F) 10(-5) M, 8 bromo-cAMP (8B) 10(-3) M, and A23187 (A) 10(-6) M. PNG levels were determined by spectrophotometric assay of hemoglobin digestion products. PNG amounts secreted were (mean per cent above basal levels of total IGG PNG units +/- SEM): H, -0.02 +/- 0.30%; I, 3.5 +/- 0.9%; C, 5.1 +/- 2.2%; CCK-8, 5.3 +/- 1.5%; F, 10.6 +/- 3.8%; 8B, 13.8 +/- 4.5%; A, 2.1 +/- 1.1%. All secretagogues except H stimulated PNG release significantly above basal levels (p less than 0.05). A primary histaminergic mechanism for pepsinogen secretion is unlikely. Since two other adenylate cyclase activators, isoproterenol and forskolin and the 3':5'-cyclic adenosine monophosphate analog 8-bromo cAMP stimulated pepsinogen secretion, cAMP-dependence is probable. Since carbachol, CCK-8, and A23187, which are believed to act via calcium-calmodulin, also stimulated pepsinogen secretion, this system, too, presumably plays a substantial role. Thus the data support a dual 3':5'-cyclic adenosine monophosphate/calcium-calmodulin modulation of pepsinogen secretion. 相似文献
2.
ME BURGE AM JOSHUA CM McNEIL R HUI MJ BOYER R ABRAHAM 《Asia-Pacific Journal of Clinical Oncology》2005,1(1):47-52
Background: Pemetrexed and cisplatin have recently been shown to significantly improve survival compared with cisplatin alone. However, there are only limited data reflecting teaching hospital experience outside a clinical trial. Pemetrexed has only been available in Australia on a restricted basis since 2002. We reviewed our experience of patients treated on the Australian ‘Special Access Scheme’ at three major thoracic oncology units. Methods: Charts were reviewed for all patients enrolled on the scheme. Data was extracted on age, World Health Organization (WHO) performance status, histology, prior therapy, time from diagnosis to starting pemetrexed, chemotherapy (pemetrexed alone or with a platinum), cycle number, response rate, actuarial progression‐free and overall survival. Doses were cisplatin 75 mg/m2 or carboplatin AUC = 5 and pemetrexed 500 mg/m2 every 21 days. Results: 52 patients (32 male and 20 female) were reviewed. Median age was 58 years and 88% were WHO 0–1. Histology included 54% epithelial, 17% biphasic (epithelial and sarcomatoid) and 21% undefined. The median time from diagnosis to administration of pemetrexed was 145 days. Sixty‐five percent had minimal surgical intervention with video assisted thoracoscopy, pleurodesis and biopsy, while 19% had received prior palliative radiation. Seventy‐one percent were chemotherapy naïve, the remaining 29% having received previous platinum and/or gemcitabine regimens. Twenty‐three percent had pemetrexed alone, 35% in combination with carboplatin and 42% with cisplatin. The median number of cycles was 4 (range 1–13). The response rate was 33%. No toxicity was observed in 20% grade 3–4 toxicity in 10% (majority nausea/vomiting). The median progression‐free and overall survival times from starting pemetrexed were 184 days and 298 days, respectively. Conclusions: Pemetrexed‐based regimens are safe and effective in a community setting in malignant mesothelioma. 相似文献
3.
American Diabetes Association The initial draft of this paper was prepared by Rebecca G. Schafer MS RD ; Betsy Bohannon MS RD; Marion J. Franz MS RD; Janine Freeman RD; Alberta Holmes MS RD; Sue McLaughlin RD; Linda B. Haas RN; Davida F. Kruger MSN RN; Rodney A. Lorenz MD; Molly M.McMahon MD 《Journal of the American Dietetic Association》1997,97(1):52-53
4.
5.
6.
7.
8.
9.
10.