全文获取类型
收费全文 | 2863篇 |
免费 | 187篇 |
国内免费 | 11篇 |
专业分类
耳鼻咽喉 | 28篇 |
儿科学 | 60篇 |
妇产科学 | 48篇 |
基础医学 | 393篇 |
口腔科学 | 55篇 |
临床医学 | 209篇 |
内科学 | 723篇 |
皮肤病学 | 68篇 |
神经病学 | 285篇 |
特种医学 | 62篇 |
外科学 | 441篇 |
综合类 | 19篇 |
预防医学 | 112篇 |
眼科学 | 26篇 |
药学 | 221篇 |
中国医学 | 4篇 |
肿瘤学 | 307篇 |
出版年
2023年 | 22篇 |
2022年 | 42篇 |
2021年 | 76篇 |
2020年 | 45篇 |
2019年 | 64篇 |
2018年 | 66篇 |
2017年 | 55篇 |
2016年 | 78篇 |
2015年 | 90篇 |
2014年 | 93篇 |
2013年 | 123篇 |
2012年 | 202篇 |
2011年 | 215篇 |
2010年 | 127篇 |
2009年 | 101篇 |
2008年 | 183篇 |
2007年 | 208篇 |
2006年 | 161篇 |
2005年 | 162篇 |
2004年 | 155篇 |
2003年 | 144篇 |
2002年 | 124篇 |
2001年 | 65篇 |
2000年 | 49篇 |
1999年 | 40篇 |
1998年 | 31篇 |
1997年 | 16篇 |
1996年 | 17篇 |
1995年 | 5篇 |
1994年 | 8篇 |
1993年 | 16篇 |
1992年 | 27篇 |
1991年 | 16篇 |
1990年 | 23篇 |
1989年 | 32篇 |
1988年 | 24篇 |
1987年 | 25篇 |
1986年 | 17篇 |
1985年 | 17篇 |
1984年 | 11篇 |
1983年 | 7篇 |
1977年 | 7篇 |
1975年 | 8篇 |
1972年 | 5篇 |
1971年 | 5篇 |
1970年 | 5篇 |
1969年 | 5篇 |
1968年 | 8篇 |
1967年 | 10篇 |
1966年 | 7篇 |
排序方式: 共有3061条查询结果,搜索用时 15 毫秒
1.
Chie Teramoto PHN RN MS Satoko Nagata PhD PHN RN Reiko Okamoto PhD PHN RN Ruriko Suzuki PHN RN MS Emiko Kishi PhD PHN RN Michie Nomura DSN PHN RN Noriko Jojima PHN RN MS Masumi Nishida PhD PHN RN Keiko Koide PhD PHN RN Emiko Kusano PhD PHN RN Saori Iwamoto PhD PHN RN Sachiyo Murashima PhD PHN RN 《Public health nursing (Boston, Mass.)》2015,32(6):654-661
2.
Sadahiro Hijikata Igen Hongo Shu-ichi Nakayama Tetsuo Yamaguchi Yoshiyuki Sekikawa Toshihiro Nozato Takashi Ashikaga 《The Canadian journal of cardiology》2019,35(1):104.e9-104.e11
Syphilis is a sexually transmitted disease caused by Treponema pallidum. Syphilitic aortitis might coexist in a dysfunctional aortic valve, but the etiology remains unclear, because microbiological diagnosis is difficult. A 62-year-old man with low-grade fever was diagnosed with aortitis and infective endocarditis, due to Treponema pallidum infection, using polymerase chain reaction analysis. This case suggests that syphilis might cause infective endocarditis. 相似文献
3.
Ravinder K. Mittal MD Barry N. Siskind MD Michio Hongo MD M. Wayne Flye MD Richard W. McCallum MD 《Digestive diseases and sciences》1986,31(4):379-384
Three patients with dysphagia caused by compression of the distal esophagus by a tortuous nonaneurysmal atherosclerotic aorta are described. All three patients were elderly women; systemic hypertension and cardiomegaly were present in two patients. Barium studies of the esophagus showed displacement and compression of the distal esophagus by the thoracic aorta. Debilitating dysphagia was treated surgically in one patient. The other two patients had milder symptoms and were managed conservatively. Esophageal manometry in these three patients showed superimposed pulsations and elevated intraluminal pressure just proximal to the lower esophageal sphincter. To evaluate the significance of these manometric findings and their correlation with clinical symptoms, we reviewed manometric tracings in 47 normal subjects. Ten of these subjects had an elevation of baseline intraluminal esophageal pressure as a result of superimposed vascular pulsations. We conclude that (1) compression of the distal esophagus by a tortuous atherosclerotic aorta in the appropriate setting can lead to clinically significant dysphagia and (2) a manometric finding of vascular compression of the esophagus does not necessarily correlate symptomatic dysphagia. 相似文献
4.
5.
Yuichi Sanada Kazuhiro Yoshida Hiroyuki Itoh Satoko Kunita Kazuto Jinushi Hideo Matsuura 《Journal of hepato-biliary-pancreatic sciences》2007,14(4):401-409
We report a case of groove pancreatitis (GP) associated with a true pancreatic cyst. An 81-year-old man who had suffered epigastric pain for 4 months was referred to Saisekai Kure Hospital. Computed tomography and endoscopic retrograde pancreatography showed a cystic lesion in the groove area of the pancreas. Serum amylase elevation and imaging findings suggested GP due to the cyst. Six weeks of medical treatment did not improve the clinical symptoms. Therefore, pancreatoduodenectomy was performed. Histologic examination revealed a true cyst with intraluminal necrosis, which produced a protein plug that obstructed the Santorini duct. The parenchyma surrounding the groove area showed marked fibrosis and inflammatory cell infiltration. GP due to true pancreatic cyst was diagnosed. Although GP is usually caused by overconsumption of alcohol, which leads to changes in the pancreatic juice and the ultimate blockage of pancreatic outflow, the histologic features in our patient suggest that true pancreatic cyst stands as a secondary cause of GP. 相似文献
6.
During the span of five years from October, 1987 to December, 1992, we have operated on six cases of carotid body tumours. Total excision was performed in five patients; one patient had 90% of the tumour excised. All patients had pre-operative balloon occlusion test; only one patient showed electroencephalographic changes. Three patients required intra-operative intraluminal shunts for various reasons. Microvascular Doppler flowmetery confirmed patency and correct placement of the shunt. Elective use of the intraluminal shunt is very useful for safe excision of carotid body tumours. Microneurosurgical techniques were used for all patients. There were no cerebrovascular sequelae and 25% of patients experienced cranial nerve injury. Average follow up was three years and none of the total excision patients have had recurrence of the tumours. 相似文献
7.
We performed a chromosome analysis of 26 pediatric brain tumors, including 20 primitive neuroectodermal tumors (PNETs), 5 astrocytomas, and I immature teratoma. Specimens were treated with collagenase, placed in overnight or short-term cultures, and harvested for chromosome analysis. Numerical and/or structural abnormalities were noted in 14 of the 20 PNETs and 4 of the 5 astrocytomas. In 13 PNETs, so-called medulloblastoma in the cerebellum, an i(17q) was the most frequent structural abnormality, accounting for 30% (4/13). Double minute chromosomes (dmin) were observed in one tumor. Near-diploidy was demonstrated in three of these PNETs, hyperdiploidy in three, and near-tetraploidy in three. We could not find any correlation of these cytogenetic findings with the prognosis. In the remaining seven PNETs other than medulloblastoma, the karyotypes of five PNETs demonstrated a variety of numerical and structural abnormalities. As to the astrocytomas, losses of chromosomes 7 and 9 with dmin were observed in two, and structural abnormalities of chromosomes 1 and 17 were also observed in two tumors. In our limited cases, however, we could not find the same chromosome abnormalities that are well known in adult astrocytomas. A congenital immature teratoma showed hyperdiploidy with increased numbers of chromosomes 3, 6, and 12. We conclude that i(17q) is an important chromosome abnormality in medulloblastomas, and that the oncogenesis of pediatric astrocytomas might be different cytogenetically from that of adult astrocytomas. 相似文献
8.
Gastrointestinal motility and autonomic nerve dysfunction] 总被引:2,自引:0,他引:2
Gastrointestinal motility is greatly influenced by both the autonomic nervous system (ANS) and the enteric nervous system (ENS). Dysfunction of ANS and/or ENS produces various kinds of dysmotility from the esophagus to the colon. Generalized autonomic dysfunction, often seen in diabetics, causes abnormal peristaltic waves in the esophagus, abnormal electrical activity of the stomach, delayed gastric emptying and delayed intestinal transit. Localized disorders of the enteric nervous system is seen in patients with achalasia and Hirschsprung's diseases. Functional disorders, without evidence of organic disorders, like non-cardiac chest pain, non-ulcer dyspepsia, irritable bowel syndrome, can be partly caused by abnormal function of autonomic nervous system. 相似文献
9.
Takuya Watanabe Keiko Takahashi Tomoko Kanome Shigeki Hongo Akira Miyazaki Shinji Koba Takashi Katagiri Rajbabu Pakara Claude R Benedict 《Hypertension research》2006,29(10):821-831
Human urotensin-II (U-II) is the most potent vasoactive peptide identified to date, and may be involved in hypertension and atherosclerosis. We investigated the effects of the interactions between U-II or other vasoactive agents and mildly oxidized low-density lipoprotein (mox-LDL) or hydrogen peroxide (H2O2) on the induction of vascular smooth muscle cell (VSMC) proliferation. Growth-arrested rabbit VSMCs were incubated with vasoactive agents (U-II, endothelin-1, angiotensin-II, serotonin, or thromboxane-A2) in the presence or absence of mox-LDL or H2O2. [3H]Thymidine incorporation into DNA was measured as an index of VSMC proliferation. On interaction with mox-LDL or H2O2, U-II induced the greatest increase in [3H]thymidine incorporation among these vasoactive agents. A low concentration of U-II (10 nmol/l) enhanced the potential mitogenic effect of low concentrations of mox-LDL (120 to 337%) and H2O2 (177 to 226%). U-II at 50 nmol/l showed the maximal mitogenic effect (161%), which was abolished by G protein inactivator (GDP-beta-S), c-Src tyrosine kinase inhibitor (radicicol), protein kinase C (PKC) inhibitor (Ro31-8220), extracellular signal-regulated kinase (ERK) kinase inhibitor (PD98059), or Rho kinase inhibitor (Y27632). Mox-LDL at 5 microg/ml showed the maximal mitogenic effect (211%), which was inhibited by free radical scavenger (catalase), intracellular and extracellular antioxidants (N-acetylcysteine and probucol), nicotinamide adenine dinucleotide phosphate oxidase inhibitor (diphenylene iodonium), or c-Jun N-terminal kinase (JNK) inhibitor (SP600125). These results suggested that U-II acts in synergy with mox-LDL in inducing VSMC DNA synthesis at the highest rate among these vasoactive agents. Activation of the G protein/c-Src/PKC/ERK and Rho kinase pathways by U-II together with the redox-sensitive JNK pathway by mox-LDL may explain the synergistic interaction between these agents. 相似文献
10.
Tomomi Iwashita Kazuo Kitazawa Jun-Ichi Koyama Hisashi Nagashima Toru Koyama Yuichiro Tanaka Kazuhiro Hongo Hiroshi Okudera Kazufumi Okamoto 《Journal of clinical neuroscience》2007,14(1):68-71
A patient with cerebral deep sinus thrombosis, which was not diagnosed on the first examination, is reported. A 46-year-old woman presented with headache and vomiting. Neurological examination and a brain computed tomography (CT) scan showed no obvious abnormal findings. The patient suffered disturbed consciousness on the day after the examination, and was admitted to our emergency centre. A CT scan and magnetic resonance imaging revealed an ischaemic lesion in the left basal ganglia, suggesting deep sinus occlusion. Anticoagulant therapy was administered. One day after admission, a CT scan showed a haematoma and severe brain swelling in the same region. Cerebral angiography demonstrated a straight sinus occlusion. Intracranial pressure was not controlled with hypothermia, and the patient died 25 days after admission. Review of the initial CT scan revealed subtle, early findings of deep venous thrombosis that were missed on first examination. 相似文献