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1.
The risk of lymph node metastasis in colorectal polyps with invasive adenocarcinoma 总被引:21,自引:11,他引:21
Santhat Nivatvongs M.D. Arun Rojanasakul M.D. Herbert M. Reiman M.D. Roger R. Dozois M.D. Bruce G. Wolff M.D. John H. Pemberton M.D. Robert W. Beart Jr. M.D. Louis F. Jacques M.D. 《Diseases of the colon and rectum》1991,34(4):323-328
One hundred fifty-one patients with colorectal polyps containing invasive adenocarcinoma treated by resection were studied to determine the incidence of lymph node metastasis and whether lymph node metastasis was related to the depth of invasion. Other variables evaluated included size and configuration of the polyp, grade of adenocarcinoma, presence or absence of lymphovascular invasion, and degree of differentiation. In patients with sessile polyps, the incidence of lymph node metastasis was 10 percent. Eighty percent of these lesions had lymphovascular invasion. For pedunculated polyps, the overall incidence of lymph node metastasis was 6 percent. However, there was no incidence of lymph node metastasis when the depth of invasion was limited to the head, neck, and stalk of the polyp (Levels 1, 2, and 3). Only when the depth of invasion reached to the base of the stalk (Level 4) was the risk of lymph node metastasis high (27 percent). The other risk factors were not associated with lymph node metastasis. We concluded that the most significant risk factor for lymph node metastasis in patients with invasive carcinoma in a polyp was invasion into the submucosa of the bowel wall (Level 4).Presented in part at the Tripartite Meeting, Birmingham, United Kingdom, June 19–21, 1989. 相似文献
2.
Michael E. Pezim M.D. Dr. John H. Pemberton M.D. Robert W. Beart Jr. M.D. Bruce G. Wolff M.D. Roger R. Dozois M.D. Santhat Nivatvongs M.D. Richard Devine M.D. Duane M. Ilstrup M.S. 《Diseases of the colon and rectum》1989,32(8):653-658
To establish whether patients with indeterminant colitis (patients with ulcerative colitis whose surgical specimens also show
features of Crohn's colitis) have an adverse outcome after ileal pouch-anal anastomosis (IPAA), the authors reviewed the pathologic
reports and postoperative status of 514 consecutive patients who underwent IPAA for chronic ulcerative colitis (CUC). Twenty-five
patients (5 percent) had features of indeterminant colitis (IC), including unusual distribution of inflammation, deep linear
ulcers, neural proliferation, transmural inflammation, fissures, creeping fat, and retention of gobletcell population. The
clinical and functional outcome of these 25 IC patients was compared with that of the remaining 489 CUC patients. The mean
follow-up was 38±18 months. No significant differences in complication rates, pouch function, incidence of “pouchitis,” or
requirement for pouch excision were detected in the two groups at follow-up. Although the authors are continuing to perform
IPAA on patients with IC, a better definition of the IC patient and a more objective, prospective analysis of outcome of IC
following IPAA is required before confident and specific treatment policies can be recommended.
Read at the meeting of the American Society of Colon and Rectal Surgeons, Washington, D.C., April 5 to 10, 1987. This article
received the Northwest Society of Colon and Rectal Surgeons Award. 相似文献
3.
4.
Nascimbeni R Nivatvongs S Larson DR Burgart LJ 《Diseases of the colon and rectum》2004,47(11):1773-1779
PURPOSE Many authors have reported high rates of local recurrence after local excision for early carcinoma of the rectum, which raises the question of whether oncologic resection gives better results. This study was designed to compare the long-term recurrence rate, long-term survival, and risk factors for T1 adenocarcinoma of the rectum treated with local excision or oncologic resection.METHODS We identified 144 patients who had T1 sessile adenocarcinoma in the lower third or middle third of the rectum. Patients who received adjuvant therapy or who had pedunculated lesions were excluded. Data included age, gender, size of lesion, histologic type of carcinoma, grade, presence of lymphovascular invasion, and depth of invasion. Outcomes were defined as five-year and ten-year cumulative probabilities of local recurrence, distant metastasis, overall survival, and cancer-free survival. The mean follow-up was 9.2 years; median follow-up was 8.1 years.RESULTS We compared 70 patients who underwent local excision with 74 patients who underwent oncologic resection. Among patients with lesions in the middle or lower third of the rectum, 1) the five-year and ten-year outcomes were significantly better for overall survival and cancer-free survival in the oncologic resection group, but there were no significant differences in local recurrence or distant metastasis; 2) the multivariate risk factors for long-term, cancer-free survival were invasion into the lower third of the submucosa, local excision, and older than aged 68 years; and 3) for lesions with invasion into the lower third of the submucosa, the oncologic resection group had lower rates of distant metastasis and better survival. Among patients with lesions in the lower third of the rectum, 1) the five-year and ten-year outcomes showed no significant differences in survival, local recurrence, or distant metastasis between the two groups; and 2) for lesions with invasion into the lower third of the submucosa, the oncologic resection group showed a trend of improved survival, which was not statistically significant, possibly because of low statistical power from the small sample size.CONCLUSIONS Patients who undergo local excision or oncologic resection for T1 carcinoma in the lower two-thirds of the rectum have a high incidence of local recurrence and distant metastasis. To improve the cure rate, the rate of recurrence must decrease. A randomized, controlled study is needed to determine whether adjuvant therapy may be beneficial.Read at the meeting of The American Society of Colon and Rectal Surgery, New Orleans, Louisiana, June 21 to 26, 2003. 相似文献
5.
Harold L. Kennedy M.D. Dr. David A. Rothenberger M.D. Stanley M. Goldberg M.D. Santhat Nivatvongs M.D. Emmanuel G. Balcos M.D. Carl E. Christenson M.D. Frederic D. Nemer M.D. Jerry L. Schottler M.D. 《Diseases of the colon and rectum》1983,26(3):145-148
Coloproctostomy or colocolostomy by peranal insertion of a circular stapling device was performed on 265 patients between
January 1978, and June 1981. A low anterior resection was performed in 174 patients. Stapler-related technical complications
occurred in 52 patients (20 per cent). Complementary transverse colostomies were performed in 11 patients, of which seven
were performed on the first 30 patients. Intraoperative complications occurred in 18 patients (7 per cent). Twenty-six major
postoperative complications occurred (10 per cent), and clinical anastomotic leaks occurred in eight patients (3 per cent).
Four postoperative deaths occurred (1.5 per cent). This study concludes that (1)coloproctostomy or colocolostomy can be safely performed by transanal insertion of a circular stapling device, (2) these instruments allow a sphincter-preserving
procedure to be performed for lesions in the low and midrectum (5 to 10 cm from the anal verge) with an acceptable early morbidity
and mortality, and (3) the majority of stapler-related technical complications can be managed without protecting colostomy.
Read at the meeting of the American Society of Colon and Rectal Surgeons, San Francisco, California, May 2 to 6, 1982. 相似文献
6.
Theodore J. Saclarides M.D. Dr. Bruce G. Wolff M.D. John H. Pemberton M.D. Richard M. Devine M.D. Santhat Nivatvongs M.D. Roger R. Dozois M.D. 《Diseases of the colon and rectum》1989,32(10):864-866
Since 1982, intraoperative colonoscopy has been performed on 66 patients. Preoperative intent was to perform a colonoscopic polypectomy during an intra-abdominal procedure in 44 patients, localize lesions that might subsequently lead to either colon resection or colotomy and polyp excision in 13, localize bleeding sites in 4, determine the extent of inflammatory bowel disease in 2, survey the colon in 2 who did not have preoperative colon radiography, and assess bowel viability in 1. Surgery proceeded as planned in 54 patients; however, colonoscopic findings extended the resection to include additional segments of bowel in 4. In four patients, polypectomy or bowel resection was avoided as a result of the colonoscopic findings. Intraoperative colonoscopy was not possible in four patients. No complications were related directly to this procedure. Intraoperative colonoscopy is a useful adjunct for localizing lesions or "clearing" the colon. In some patients, colonoscopic findings may change the extent of resection performed. 相似文献
7.
Prophylactic oophorectomy in colorectal carcinoma 总被引:3,自引:0,他引:3
Tonia M. Young-Fadok M.D. Dr. Bruce G. Wolff M.D. Santhat Nivatvongs M.D. Philip P. Metzger M.D. Duane M. Ilstrup M.S. 《Diseases of the colon and rectum》1998,41(3):277-283
Controversy exists regarding the role of prophylactic oophorectomy during resection for primary colorectal cancer. PURPOSE: A prospective, randomized trial was initiated to evaluate the influence of oophorectomy on recurrence and survival in patients with Dukes Stages B and C colorectal cancer. METHOD: Between November 1986 and March 1997, 155 patients were randomized to oophorectomy or no oophorectomy at laparotomy for resection of colorectal cancer. RESULTS: No incidence of gross or microscopic metastatic disease to the ovary was found among 77 patients randomized to oophorectomy, in contrast to previous reports. Preliminary crude survival curves suggested a survival benefit for oophorectomy between two and three years from surgery, but Kaplan-Meier survival analysis indicated that this was not statistically significant and the benefit does not appear to persist at five years. Kaplan-Meier curves of recurrence-free survival, however, suggest a more substantial separation of the curves, with 80 percentvs. 65 percent five-year disease-free survival for oophorectomyvs. nonoophorectomy, but further patient accrual is necessary to provide sufficient statistical power. CONCLUSIONS: Occult colorectal carcinoma metastatic to the ovaries has not been documented in this series of putative Dukes Stages B and C tumors. The possibility of a recurrence-free survival advantage emphasizes the need to continue this preliminary work.Read at the meeting of The American Society of Colon and Rectal Surgeons, Philadelphia, Pennsylvania, June 22 to 26, 1997. 相似文献
8.
Paul Belliveau M.D. Dr. Stanley M. Goldberg M.D. David A. Rothenberger M.D. Santhat Nivatvongs M.D. 《Diseases of the colon and rectum》1982,25(2):118-121
Forty-eight patients treated for chronic incapacitating constipation by surgical resection were reviewed. Thirty-seven had
subtotal colectomy, eight had left colectomy, two had right hemicolectomy, and one had ileostomy, colectomy, and a Hartmann
pouch. There were significant complications (21 per cent) and one mortality (2 per cent). A long-term successful outcome was
found in 81 per cent of the patients on follow-up. Physiologic studies are recommended to improve the selection of patients.
Read at the meeting of the American Society of Colon and Rectal Surgeons, Colorado Springs, Colorado, June 7 to 11, 1981. 相似文献
9.
Bruce L. Cunningham M.D. Santhat Nivatvongs M.D. Dr. Alan R. Shons M.D. Ph.D. 《Diseases of the colon and rectum》1979,22(1):51-54
Summary We have presented a rare instance of Fournier's synergistic gangrene following anorectal examination and biopsy. Early diagnosis
and extensive debridement were necessary. Extensive debridement necessitated a significant reconstruction task. This technique
of genital reconstruction should be familiar to surgeons dealing with colonic and rectal disease. 相似文献
10.
Overlapping sphincteroplasty for acquired anal incontinence 总被引:15,自引:15,他引:0
David T. Fang M.D. Santhat Nivatvongs M.D. Fred D. Vermeulen M.D. Fred N. Herman M.D. Stanley M. Goldberg M.D. David A. Rothenberger M.D. 《Diseases of the colon and rectum》1984,27(11):720-722
When defects of the anal sphincter are caused by trauma, surgical correction can be successful even in long-standing cases.
At the University of Minnesota, we used overlapping sphincteroplasty in 79 patients with fecal incontinence from 1952 to 1982.
There were 62 women and 17 men. Ages ranged from 17 to 68 years. Incontinence had been present from three weeks to 40 years
and had been caused by childbirth, previous anorectal surgery, trauma or rectal prolapse. Following overlapping sphincteroplasty,
there was one postoperative death and 13 complications. Complications included temporary difficulty in voiding, excessive
bleeding, abscess formation, fecal impaction, and hematoma. Seventy-six of the 78 surviving patients were followed for an
average of 35 months. Results ranged from excellent to poor with only one failure. From our experience it was concluded that
several factors were important for good surgical results. 1) The patient must have intact neuromuscular bundle with detectable
voluntary sphincter contraction. 2) If a primary repair has failed, a minimum duration of three months should elapse before
overlapping sphincteroplasty is attempted. 3) Scar tissue from the severed muscles should not be excised. 4) The internal
and external sphincter muscles should not be separated. 5) A temporary concomitant colostomy is not necessary.
Read at the meeting of the American Society of Colon and Rectal Surgeons, Boston, Massachusetts, June 5–9, 1983.
The work for this paper was performed at the Division of Colon and Rectal Surgery. Department of Surgery, University of Minnesota
Medical School, Minneapolis, Minnesota. 相似文献