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Meta-analysis has been little explored to make an overall assessment of linkage from different studies. In practice, it is likely that published linkage studies will only report p-values. We compared the performance of the widely used Fisher method for combining p-values with that of pooling raw data. More loci were consistently found by pooling raw data. In the absence of further information, combining p-values can provide an overall, but limited, assessment of different linkage studies. However, meta-analysis would be better viewed as a preliminary step toward the goal of analyzing the pooled raw data. 相似文献
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Lawrence DM Phillips GC Sublette NJ Plager BJ Fuhs PA Sain DD Bateman MT King CC 《Healthcare executive》1996,11(5):18-21
When Healthcare Executive asked managed care organization CEOs and board chairs to identify governance challenges, they found the question so easy that it was difficult to limit their responses. while all the healthcare leaders interviewed pointed to the need to--and challenge of--staying ahead of the changes affecting the healthcare field, many identified challenges that were more specific to their organizations, markets, or patient population. Some also pointed out that while their challenges may be shared by hospitals and other provider organizations, there were aspects of each that were particularly relevant to managed care organizations, which often offer a variety of products in a number of different of markets. 相似文献
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Validity and reliability of the Turkish version of the readiness for hospital discharge scale/short form
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Mat Sain AH 《World journal of surgery》2004,28(2):217; author reply 217-217; author reply 218
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Adam Bennett Stephen R. Sain Enrique Vargas Lorna G. Moore 《American journal of human biology》2008,20(5):592-597
Hypoxia exerts a profound depressant effect on fetal growth, lowering birth weight, and raising mortality risk. Multigenerational high‐altitude populations are relatively protected from this birth‐weight decline, leading us to hypothesize that genetic factors were involved. We asked if the amount of high‐ versus low‐altitude ancestry influenced birth weight at high altitude and, specifically, whether such influences were affected by parent‐of‐origin effects (i.e., genomic imprinting). Medical records were reviewed from 1,343 consecutive, singleton deliveries in La Paz, Bolivia (3,600 m) of high‐ (Andean) or low‐ (European) altitude ancestry. Parental surnames were used to classify ancestry as Andean, European, Mestizo (“mixed”) or some combination thereof. The effects of population ancestry on birth weight were determined by categorical, conditional linear regression. Babies born at altitude with two Andean parents weighed 252 g more than their European counterparts, with the protective effect being proportional to the amount of Andean parentage and independent of maternal parity, body size, smoking, or socioeconomic status. Paternal compared with maternal transmission raised birth weight 81 g for a given ancestry group. We concluded that indigenous high‐altitude ancestry protected against hypoxia‐associated fetal growth reduction in a dose‐dependent fashion consistent with the involvement of genetic factors. Further, some of the genes involved appeared to be influenced by parent‐of‐origin effects, given that maternal transmission restricted and paternal transmission enhanced fetal growth. Am. J. Hum. Biol., 2008. © 2008 Wiley‐Liss, Inc. 相似文献
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Fusion transcripts and transcribed retrotransposed loci discovered through comprehensive transcriptome analysis using Paired-End diTags (PETs)
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R Azad K Vivek Y Sharma P Chandra S Sain A Venkataraman 《Indian journal of ophthalmology》2012,60(4):263-266