全文获取类型
收费全文 | 7865篇 |
免费 | 406篇 |
国内免费 | 19篇 |
专业分类
耳鼻咽喉 | 97篇 |
儿科学 | 167篇 |
妇产科学 | 102篇 |
基础医学 | 1035篇 |
口腔科学 | 164篇 |
临床医学 | 468篇 |
内科学 | 1842篇 |
皮肤病学 | 155篇 |
神经病学 | 622篇 |
特种医学 | 227篇 |
外科学 | 1249篇 |
综合类 | 17篇 |
预防医学 | 300篇 |
眼科学 | 265篇 |
药学 | 619篇 |
中国医学 | 23篇 |
肿瘤学 | 938篇 |
出版年
2023年 | 30篇 |
2022年 | 84篇 |
2021年 | 154篇 |
2020年 | 90篇 |
2019年 | 101篇 |
2018年 | 134篇 |
2017年 | 94篇 |
2016年 | 135篇 |
2015年 | 121篇 |
2014年 | 190篇 |
2013年 | 236篇 |
2012年 | 369篇 |
2011年 | 410篇 |
2010年 | 240篇 |
2009年 | 181篇 |
2008年 | 399篇 |
2007年 | 411篇 |
2006年 | 413篇 |
2005年 | 402篇 |
2004年 | 436篇 |
2003年 | 417篇 |
2002年 | 384篇 |
2001年 | 206篇 |
2000年 | 220篇 |
1999年 | 216篇 |
1998年 | 82篇 |
1997年 | 61篇 |
1996年 | 69篇 |
1995年 | 62篇 |
1994年 | 52篇 |
1993年 | 50篇 |
1992年 | 154篇 |
1991年 | 145篇 |
1990年 | 141篇 |
1989年 | 159篇 |
1988年 | 153篇 |
1987年 | 146篇 |
1986年 | 132篇 |
1985年 | 131篇 |
1984年 | 94篇 |
1983年 | 55篇 |
1979年 | 67篇 |
1978年 | 39篇 |
1977年 | 41篇 |
1975年 | 32篇 |
1974年 | 33篇 |
1972年 | 30篇 |
1971年 | 26篇 |
1969年 | 35篇 |
1968年 | 30篇 |
排序方式: 共有8290条查询结果,搜索用时 15 毫秒
1.
Kensuke Kudou Hiroshi Saeki Yuichiro Nakashima Shun Sasaki Tomoko Jogo Kosuke Hirose Qingjiang Hu Yasuo Tsuda Koichi Kimura Ryota Nakanishi Nobuhide Kubo Koji Ando Eiji Oki Tetsuo Ikeda Yoshihiko Maehara 《American journal of surgery》2019,217(4):757-763
Background
There were few studies assessed the postoperative sarcopenia in patients with cancers. The objective of present study was to assess whether postoperative development of sarcopenia could predict a poor prognosis in patients with adenocarcinoma of esophagogastric junction, (AEG) and upper gastric cancer (UGC).Methods
Patients with AEG and UGC who were judged as non-sarcopenic before surgery were reassessed the presence of postoperative development of sarcopenia 6 months after surgery. Patients were divided into the development group or non-development group, and clinicopathological factors and prognosis between these two groups were analyzed.Results
The 5-year overall survival rates were significantly poorer in the development group than non-development group (68.0% vs. 92.6%, P?=?0.0118). Multivariate analyses showed that postoperative development of sarcopenia was an independent prognostic factor for poor overall survival (P?=?0.0237).Conclusions
Postoperative development of sarcopenia was associated with a poor prognosis in patients with AEG and UGC. 相似文献2.
Patricia A Wilkosz Sachiko Miyahara Oscar L Lopez Steven T Dekosky Robert A Sweet 《The American journal of geriatric psychiatry》2006,14(4):352-360
BACKGROUND: Psychotic symptoms in Alzheimer disease (AD+P) identify a heritable phenotype associated with more rapid cognitive decline. The authors have proposed that AD+P is itself a composite of a misidentification and a paranoid subtype with increased cognitive impairment restricted to the misidentification type. Most prior studies of the clinical correlates of AD+P have been limited, however, by the inclusion of prevalent cases. METHODS: Subjects with possible or probable AD or mild cognitive impairment (MCI) without psychosis at study entry were assessed at the time of initial presentation and then annually. Psychotic symptoms were assessed using the CERAD Behavioral Rating Scale. Survival analyses used Cox proportional hazard models with time-dependent covariates to examine the predictors of psychosis onset. RESULTS: A total of 288 subjects completed at least one follow-up examination. Mean duration of follow-up was 22.1 months. The incidence of psychosis was 0.19 per person-year. Cognitive impairment was associated with onset of psychosis, largely as a result of its association with onset of the misidentification, but not the paranoid, subtype. Including psychotropic medication use in the model revealed an association of antidepressant use with the onset of psychosis. This latter association appeared to arise from an underlying association between depression and the risk of psychosis onset rather than from antidepressant treatment. CONCLUSION: These findings are consistent with the hypothesis that the misidentification and the paranoid subtypes each define a more biologically homogeneous group than AD+P as a whole. Further exploration of the relationship between depressive symptoms and psychosis in patients with AD is warranted. 相似文献
3.
Sachiko Goto Akiyoshi Tsuji Teiko Murai Minoru Nishida Hiroko Tsukano Haruo Watanabe 《Journal of infection and chemotherapy》1998,4(1):16-19
Although there are effective antibacterial agents against plague, newer antibacterial agents have been developed which show
more potent activity against other bacterial organisms, but have not been tested againstYersinia pestis. A strain ofYersinia pestis was selected (no. 22; National Institute of Infectious Diseases, Tokyo, Japan) that caused a systemic infection in mice.Y. pestis no. 22 was intraperitoneally inoculated into DDY-strain mice, and 13 oral or 6 injectable antibacterial drugs given to the
infected mice at varying doses 1 and 24 hours after infection. Levofloxacin, sparfloxacin and ofloxacin were the most effective
oral agents against the infection, and prulifloxacin and pazufloxacin were also effective but to a lesser extent. Also, gentamicin
and arbekacin were the most potent injectable antibacterial agents againstY. pestis. These results suggest that there are several new drugs, both oral and injectable, which exert excellent in vivo antibacterial
activity against a mouse infection model and may be useful for the clinical treatment of plague. 相似文献
4.
5.
Pathogenic role of connective tissue growth factor (CTGF/CCN2) in osteolytic metastasis of breast cancer. 总被引:5,自引:0,他引:5
6.
Tatsurou Tanaka Yasuhiro Morimoto Hiroshi Takano Kazuhiro Tominaga Shinji Kito Sachiko Okabe Tetsu Takahashi Jin-ichi Fukuda Takeshi Ohba 《Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics》2005,100(5):609-613
OBJECTIVE: To evaluate a proposed technique for the 3-dimensional (3D) detection of hemangiomas, including vascular malformation and their feeding arteries, in the head and neck. The new technique combines phase-contrast magnetic resonance angiography (PCMRA) without contrast medium and 3D fast asymmetric spin-echo (FASE) sequences. METHODS: The technique was applied to 3 patients having hemangiomas in the head and neck region. In 1 patient the image obtained with the proposed technique was compared to that obtained by standard contrast angiography. RESULTS: In all 3 patients, the 3D presence of the hemangiomas and the feeding arteries were well defined in images created by the proposed technique. Additionally, the characterization of the hemangioma's 3D structure and distribution of the feeding arteries coincided with those observed using contrast angiography in the case for which contrast angiography was also performed. CONCLUSIONS: Preliminary experience shows that the proposed technique combining 3D-FASE and 3D-PCMRA is useful to visualize both the 3D structure of hemangiomas and to identify the 3D distribution of the feeding arteries without using contrast medium. 相似文献
7.
8.
9.
Binding profile of SM-9018, a novel antipsychotic candidate 总被引:3,自引:0,他引:3
T Kato A Hirose Y Ohno H Shimizu H Tanaka M Nakamura 《Japanese journal of pharmacology》1990,54(4):478-481
The present study employed various receptor-binding assays to clarify the biochemical characteristics of SM-9018. SM-9018 possessed very high affinity for 5-HT2, D2 and 5-HT1A receptors (Ki = 0.61, 1.4 and 2.9 nM, respectively), and it had moderate affinity for alpha 1 and D1 receptors (Ki = 17 and 41 nM, respectively). However, SM-9018 had only negligible affinity for alpha 2, opiate, glutamate, phencyclidine, benzodiazepine and GABAA receptors. These results suggest that SM-9018 may be a novel antipsychotic agent with binding affinity for 5-HT2 and 5-HT1A receptors. 相似文献
10.
Gliomatosis cerebri with good prognosis 总被引:4,自引:0,他引:4
Seiji Kannuki Hideki Hondo Kunio Ii Takanori Hirose Keizo Matsumoto 《Brain tumor pathology》1997,14(1):53-57
A 52-year-old man was admitted to our clinic with severe headache and bilateral papilledema. Magnetic resonance (MR) images
on admission demonstrated diffuse swelling of the cerebral cortex without formation of a tumor mass. Biopsy revealed diffuse
infiltration with neoplastic glial cells. After radiation and chemotherapy, the MR images returned to normal. The morphological
and neurological features of the present case met the criteria for gliomatosis cerebri. However, this patient showed an unusually
good response to radiation and chemotherapy. 相似文献