全文获取类型
收费全文 | 2786篇 |
免费 | 142篇 |
国内免费 | 22篇 |
专业分类
耳鼻咽喉 | 39篇 |
儿科学 | 130篇 |
妇产科学 | 12篇 |
基础医学 | 394篇 |
口腔科学 | 23篇 |
临床医学 | 154篇 |
内科学 | 677篇 |
皮肤病学 | 122篇 |
神经病学 | 163篇 |
特种医学 | 71篇 |
外科学 | 531篇 |
综合类 | 9篇 |
预防医学 | 79篇 |
眼科学 | 51篇 |
药学 | 156篇 |
中国医学 | 10篇 |
肿瘤学 | 329篇 |
出版年
2023年 | 20篇 |
2022年 | 30篇 |
2021年 | 44篇 |
2020年 | 46篇 |
2019年 | 52篇 |
2018年 | 59篇 |
2017年 | 50篇 |
2016年 | 72篇 |
2015年 | 83篇 |
2014年 | 117篇 |
2013年 | 102篇 |
2012年 | 185篇 |
2011年 | 164篇 |
2010年 | 88篇 |
2009年 | 87篇 |
2008年 | 161篇 |
2007年 | 157篇 |
2006年 | 127篇 |
2005年 | 137篇 |
2004年 | 135篇 |
2003年 | 145篇 |
2002年 | 128篇 |
2001年 | 62篇 |
2000年 | 60篇 |
1999年 | 63篇 |
1998年 | 33篇 |
1997年 | 33篇 |
1996年 | 18篇 |
1995年 | 18篇 |
1994年 | 28篇 |
1993年 | 14篇 |
1992年 | 34篇 |
1991年 | 28篇 |
1990年 | 50篇 |
1989年 | 48篇 |
1988年 | 41篇 |
1987年 | 43篇 |
1986年 | 40篇 |
1985年 | 25篇 |
1984年 | 16篇 |
1983年 | 14篇 |
1982年 | 7篇 |
1981年 | 10篇 |
1980年 | 8篇 |
1979年 | 5篇 |
1978年 | 10篇 |
1977年 | 13篇 |
1975年 | 9篇 |
1969年 | 4篇 |
1967年 | 4篇 |
排序方式: 共有2950条查询结果,搜索用时 31 毫秒
1.
Takahiro Namiki Chika Takano Ryoji Aoki Quang Duy Trinh Ichiro Morioka Satoshi Hayakawa 《Congenital anomalies》2022,62(1):38-41
Congenital rubella syndrome (CRS) results from maternal rubella virus infection in early pregnancy. Abnormal neuroimaging findings have been analyzed in a small number of CRS patients in the past; however, their clinical significance has been poorly addressed. Therefore, we have investigated the neuroimaging findings of 31 patients with CRS from previous studies. The most common finding was parenchymal calcification, which was observed in 18 of 31 patients (58.1%). A multivariable logistic regression model showed that it was associated with psychomotor or mental retardation (p = 0.018), suggesting that parenchymal calcification in CRS could be a prognostic factor. 相似文献
2.
Comparative safety study on severe anemia by simeprevir versus telaprevir‐based triple therapy for chronic hepatitis C 下载免费PDF全文
Eiichi Ogawa Norihiro Furusyo Eiji Kajiwara Hideyuki Nomura Akira Kawano Kazuhiro Takahashi Kazufumi Dohmen Takeaki Satoh Koichi Azuma Makoto Nakamuta Toshimasa Koyanagi Kazuhiro Kotoh Shinji Shimoda Jun Hayashi The Kyushu University Liver Disease Study Group 《Journal of gastroenterology and hepatology》2015,30(8):1309-1316
3.
Loss of heterozygosity alterations associated with progesterone therapy in endometrial hyperplasia and adenocarcinoma 总被引:1,自引:0,他引:1
M. Yasuda S. Kotajima H. Kajiwara S. Takekoshi R. Y. Osamura T. Yoshitake† T. Muramatsu† T. Miyamoto† M. Murakami† & T. Shinozuka† 《International journal of gynecological cancer》2005,15(1):155-162
Loss of heterozygosity (LOH) was analyzed in four patients with endometrial hyperplasia (EH) with atypia (two patients) and without atypia (two patients) and in five patients with endometrial adenocarcinoma (EAC) to clarify the clinicopathologic relationship between genetic alterations and hormone therapy. Each patient was initially administered high-dose medroxyprogesterone acetate (MPA) as a uterine-sparing treatment. The five microsatellite markers used to analyze LOH were at chromosomal loci 8p22.1, 8p21, 8p21.3, 8p22, and 8p22. DNA was extracted from paraffin-embedded sections before, during, and after MPA therapy using laser capture microdissection. As a result, LOH was more frequently detected after MPA therapy (overall ratios were 16, 17, and 29% before, during, and after MPA therapy, respectively). LOH is more easily detected in EH loci than in EAC loci before MPA. For EAC, initial LOH detection on chromosome 8 may be related to an incomplete response to MPA, but negative LOH does not guarantee a favorable treatment outcome. For EH or atypical endometrial hyperplasia, it is unknown whether LOH alteration associated with MPA therapy is related to atypia of the disease. 相似文献
4.
5.
Met-RANTES ameliorates fibrous airway obliteration and decreases ERK expression in a murine model of bronchiolitis obliterans. 总被引:1,自引:0,他引:1
Osamu Uchida Naohiro Kajiwara Aeru Hayashi Kuniharu Miyajima Takayoshi Nagatsuka Hiroki Hayashi Masahiro Taira Masakazu Kimura Masahiro Tsuboi Harubumi Kato 《Annals of thoracic and cardiovascular surgery》2007,13(2):82-86
OBJECTIVES: Bronchiolitis obliterans (BO) is the main cause of late mortality among long-term survivors of lung transplantation. Chemokine-chemokine receptor (CCR) interaction and subsequent recruitment of infiltrating cells to the graft are early events in the development of chronic rejection of transplanted lungs. The present study investigated whether blockade of chemokine receptors CCR1 and CCR5 with Met-regulated-on-activation, normal T cells expressed and secreted (RANTES), an amino-terminal modified derivative of RANTES/CCL5, affects the development of BO in murine model and we sought to determine the expression of RANTES/CCL5 and their relationship with extracellular signal-regulated kinase (ERK). Materials and Methods: BALB/c mouse tracheas were heterotopically transplanted into C57Black6 recipients and treated for 21 days with either Met-RANTES at 20 microg/day or vehicle. Animals were killed at 21 days after transplantation for histologic examination of ERK expression. RESULTS: RANTES/CCL5 was highly expressed in allografts compare to isografts. Met-RANTES treatment ameliorated fibrous airway obliteration in a mouse model of BO and decreased ERK expression. CONCLUSION: Blockade of chemokine receptors by Met-RANTES ameliorated airway obliteration and decreased ERK expression. These findings suggest that chemokine receptors CCR1 and CCR5 play significant roles in the development of chronic rejection and ERK may be a new molecular target for chronic rejection. 相似文献
6.
Use of Glycopeptidolipid Core Antigen for Serodiagnosis of Mycobacterium avium Complex Pulmonary Disease in Immunocompetent Patients 下载免费PDF全文
Seigo Kitada Ryoji Maekura Naomi Toyoshima Takashi Naka Nagatoshi Fujiwara Masami Kobayashi Ikuya Yano Masami Ito Kazuo Kobayashi 《Clinical and Vaccine Immunology : CVI》2005,12(1):44-51
We report the development of a serodiagnostic method for Mycobacterium avium complex (MAC) disease with an enzyme immunoassay (EIA) with the MAC-specific glycopeptidolipid (GPL) core as the antigen. In this study, we confirmed by EIA that the GPL core antibody was in the sera of immunocompetent patients with MAC disease. The EIA for quantifying the GPL core antibody was evaluated as a clinical tool for serodiagnosis of pulmonary MAC disease. A significant increase in GPL core antibodies (immunoglobulins G, A, and M) was detected in sera of patients with MAC pulmonary diseases when they were compared to patients who were colonized with MAC, patients with Mycobacterium kansasii disease or tuberculosis, and healthy subjects. The sensitivities and specificities of the GPL core-based EIA for diagnosis of MAC pulmonary disease were 72.6% and 92.2%, respectively, for IgG, 92.5% and 95.1%, respectively, for IgA, and 78.3% and 91.0%, respectively, for IgM. The best sensitivity and specificity were obtained by measuring immunoglobulin A antibodies against GPL core antigen. The level of GPL core antibodies reflected disease activity, since it decreased in cured MAC patients who had responded to chemotherapy. Measurement of serum antibodies against GPL core is useful for both diagnosis and assessment of disease activity in MAC disease of the lung. 相似文献
7.
Nucleolar organizer regions in meningioma 总被引:1,自引:0,他引:1
Seventy-eight cases of meningioma and related tumors were examined independently using a simple and reproducible argyrophilic method for the demonstration of nucleolar organizer regions (AgNORs) and staining with bromodeoxyuridine monoclonal antibody. The mean number of AgNORs per cell and the bromodeoxyuridine labeling index were shown to be linearly related (r = 0.84, P less than 0.001). The mean AgNOR number was 2.99 for meningeal sarcoma, 2.29 for anaplastic meningioma, 2.08 for hemangiopericytic meningioma. 1.72 for recurrent meningioma without atypical histological findings, and 1.52 for nonrecurrent meningioma. We noted that the mean number of AgNORs reflected the cellular kinetics of a tumor and was related to histological grade and clinical behavior. 相似文献
8.
Yasuhiro Sano Shigeharu Yamashiro Asuka Komano Hisashi Maruko Hiroshi Sekiguchi Yasuo Takayama Ryoji Sekioka Kouichiro Tsuge Isaac Ohsawa Mieko Kanamori-Kataoka Yasuo Seto Akiyoshi Satoh 《Forensic Toxicology》2007,25(2):76-79
We previously reported that the Guardian Bio-Threat Alert (BTA) system could detect (detection limit: about 0.1 μg/ml) staphylococcal
enterotoxin B (SEB), botulinum toxins (BTX) A and B, and ricin, with no interference by white-powdered materials or colored
matrices. In this study, the capability of the BTA system was further assessed. With 10 min of preheating at 60°C, all toxins
could be detected, but with preheating at 80°C, BTX A and B and ricin became undetectable. About 20% SEB could be detected
after heating at 80°C, but this detection ability was completely removed after heating at 100°C. The effects of chemicals
usually used for decontamination, such as sodium hypochlorite, hydrogen peroxide, formaldehyde, and sodium nitrite, on the
detectability of SEB, BTX A, or ricin in the BTA system were also tested. The concentrations giving 50% line intensity for
SEB, BTX A, and ricin were 3.1, 11, and 15 μM for sodium hypochlorite and 88, 210, and 60 mM for formaldehyde, respectively.
The addition of hydrogen peroxide or sodium nitrite did not decrease the detectability even when used at high concentrations. 相似文献
9.
Yoshie Ochiai Kazuhiro Kurisu Takashi Kajiwara Hiroshi Kumeda Ryuji Tominaga 《The Japanese Journal of Thoracic and Cardiovascular Surgery》2004,52(2):81-83
We describe a case of type B aortic dissection with large ascending aortic aneurysm occurring 12.8 years after aortic root
replacement (Cabrol procedure) in a non-Marfan patient with cystic medial necrosis of the aorta. We have successfully performed
an extended total aortic arch replacement using a four-branched graft through the “L-indsion” approach (a combination of a
left anterior thoracotomy and upper half median sternotomy). Of note, a histological specimen from the aneurysmal ascending
aortic wall revealed “healed aortic dissection” with fibrous tissue replacing the media and intima in addition to multiple
foci of cystic medial necrosis. 相似文献
10.