全文获取类型
收费全文 | 563篇 |
免费 | 27篇 |
国内免费 | 7篇 |
专业分类
儿科学 | 10篇 |
妇产科学 | 5篇 |
基础医学 | 108篇 |
口腔科学 | 8篇 |
临床医学 | 63篇 |
内科学 | 115篇 |
皮肤病学 | 10篇 |
神经病学 | 22篇 |
特种医学 | 157篇 |
外科学 | 28篇 |
综合类 | 4篇 |
预防医学 | 25篇 |
眼科学 | 2篇 |
药学 | 19篇 |
中国医学 | 1篇 |
肿瘤学 | 20篇 |
出版年
2023年 | 3篇 |
2022年 | 8篇 |
2021年 | 8篇 |
2020年 | 8篇 |
2019年 | 6篇 |
2018年 | 10篇 |
2017年 | 7篇 |
2016年 | 7篇 |
2015年 | 5篇 |
2014年 | 6篇 |
2013年 | 16篇 |
2012年 | 11篇 |
2011年 | 19篇 |
2010年 | 15篇 |
2009年 | 14篇 |
2008年 | 12篇 |
2007年 | 17篇 |
2006年 | 21篇 |
2005年 | 19篇 |
2004年 | 11篇 |
2003年 | 12篇 |
2002年 | 9篇 |
2001年 | 11篇 |
2000年 | 7篇 |
1999年 | 12篇 |
1998年 | 16篇 |
1997年 | 23篇 |
1996年 | 23篇 |
1995年 | 16篇 |
1994年 | 23篇 |
1993年 | 14篇 |
1992年 | 6篇 |
1991年 | 15篇 |
1990年 | 6篇 |
1989年 | 27篇 |
1988年 | 22篇 |
1987年 | 14篇 |
1986年 | 24篇 |
1985年 | 16篇 |
1984年 | 15篇 |
1983年 | 5篇 |
1982年 | 13篇 |
1981年 | 6篇 |
1980年 | 6篇 |
1979年 | 2篇 |
1978年 | 5篇 |
1977年 | 10篇 |
1976年 | 6篇 |
1975年 | 6篇 |
1935年 | 1篇 |
排序方式: 共有597条查询结果,搜索用时 15 毫秒
1.
Hillmann JS; Mesgarzadeh M; Revesz G; Bonakdarpour A; Clancy M; Betz RR 《Radiology》1987,165(3):769-773
Proximal femoral focal deficiency, an uncommon congenital anomaly, necessitates early radiologic classification for surgical planning and treatment. Objective radiographic criteria, including femoral length index, acetabular depth index, acetabular angle index, and shape of the proximal femur were determined in 49 patients before cartilaginous ossification of the femoral capital epiphysis; final classification was based on follow-up radiographs or findings at arthrography or surgery. These parameters were analyzed to determine the accuracy and contributions of each in classification. Correct classification into one of three groups was possible in 86% of cases with use of three of the parameters: femoral length index, acetabular depth index, and shape of the proximal femur. The acetabular angle was found to contribute insignificantly to classification. Magnetic resonance imaging, used in only one case, depicted the nonossified cartilaginous femoral capital epiphysis, thus obviating the need for invasive diagnostic procedures and facilitating early classification. 相似文献
2.
3.
4.
5.
The role of the complement system in innate immunity 总被引:4,自引:0,他引:4
Complement is a major component of innate immune system involved in defending against all the foreign pathogens through complement
fragments that participate in opsonization, chemotaxis, and activation of leukocytes and through cytolysis by C5b-9 membrane
attack complex. Bacterias and viruses have adapted in various ways to escape the complement activation, and they take advantage
of the complement system by using the host complement receptors to infect various cells. Complement activation also participates
in clearance of apoptotic cells and immune, complexes. Moreover at sublytic dose, C5b-9 was shown to promote cell survival.
Recently it was also recognized that complement plays a key role in adaptive immunity by modulating and modifying the T cell
responses. All these data suggest that complement activation constitutes a critical link between the innate and acquired immune
responses. 相似文献
6.
The role of complement activation in atherosclerosis 总被引:6,自引:0,他引:6
Atherosclerosis is a chronic inflammatory disease in which dyslipidemia, inflammation, and the immune system play an important pathogenetic role. A role in atherogenesis was demonstrated for monocyte/macrophages, complement system, and T-lymphocytes. Complement activation and C5b-9 deposition occurs both in human and experimental atherosclerosis. Complement C6 deficiency has a protective effect on diet-induced atherosclerosis, indicating that C5b-9 assembly is required for the progression of atherosclerotic lesions. The maturation of atherosclerotic lesions beyond the foam cell stage was shown to be strongly dependent on an intact complement system. C5b-9 may be responsible for cell lysis, and sublytic assembly of C5b-9 induces smooth muscle cell (SMC) and endothelial cell (EC) activation and proliferation. All these data suggest that activation of the complement system plays an important role in atherogenesis. 相似文献
7.
8.
Life expectancy in British Marfan syndrome populations 总被引:2,自引:0,他引:2
JR Gray AB Bridges RR West L. McLeish AG Stuart JCS Dean MEM Porteous M. Boxer SJ Davies 《Clinical genetics》1998,54(2):124-128
A total of 206 patients with Marfan syndrome were ascertained throughout genetic clinics in Wales and Scotland during the period 1970–1990. There were 45 deaths representing 22% of the cohort. Mean age at death was 45.3 ± 16.5 years. 50% median cumulative survival in the total cohort (n = 206) was 53 years for males and 72 years for females. Multivariate analysis confirmed severity as the best independent indicator of survival. These findings and survival curves will assist in the counselling of British families and individuals with Marfan syndrome. 相似文献
9.
Adrian Florin Gal Vasile Rus Sanda Andrei Viorel Miclăuş 《Journal of histotechnology》2020,43(2):97-101
ABSTRACT Early detection of apoptotic cells on histological slides is of major importance for both diagnostic and research areas. In the current study, the aim was to propose a convenient method to stain the mitochondria and establish whether hepatocytes undergoing apoptosis can be identified in tissue sections using the proposed method. Liver tissue from five adult chinchillas was fixed with 10% neutral buffered formalin for Goldner’s trichrome (GT) and Groat’s iron hematoxylin and eosin (HE) stains and with Kolster’s fixative for the Heidenhain’s iron hematoxylin procedure. The HE and GT-stained sections showed the morphological features consistent with apoptosis i.e., homogenous intensely acidophilic cytoplasm, cell shrinkage with an irregular outline, nuclear shrinkage with cloudy karyoplasm, and karyopyknosis in the late stage. Sections stained with Heidenhain’s iron hematoxylin method was used to pinpoint mitochondria and revealed cells which were undergoing the first stages of the apoptosis process i.e., disappearance of mitochondria from the cell, chromatin condensation and margination, paracentral localization of nucleoli, and vacuolated nuclei. In more advanced stages of apoptosis, cells presented significant nuclear and cytoplasmic changes. It was concluded that this is the first report targeting the mitochondria, by performing inexpensive histological staining techniques, in order to assess dead cells in situ. 相似文献
10.