全文获取类型
收费全文 | 1653篇 |
免费 | 94篇 |
国内免费 | 7篇 |
专业分类
耳鼻咽喉 | 13篇 |
儿科学 | 47篇 |
妇产科学 | 30篇 |
基础医学 | 263篇 |
口腔科学 | 44篇 |
临床医学 | 110篇 |
内科学 | 417篇 |
皮肤病学 | 73篇 |
神经病学 | 136篇 |
特种医学 | 41篇 |
外科学 | 181篇 |
综合类 | 11篇 |
预防医学 | 85篇 |
眼科学 | 19篇 |
药学 | 108篇 |
中国医学 | 2篇 |
肿瘤学 | 174篇 |
出版年
2023年 | 18篇 |
2022年 | 24篇 |
2021年 | 56篇 |
2020年 | 25篇 |
2019年 | 29篇 |
2018年 | 38篇 |
2017年 | 35篇 |
2016年 | 38篇 |
2015年 | 38篇 |
2014年 | 55篇 |
2013年 | 53篇 |
2012年 | 100篇 |
2011年 | 123篇 |
2010年 | 66篇 |
2009年 | 50篇 |
2008年 | 97篇 |
2007年 | 100篇 |
2006年 | 88篇 |
2005年 | 101篇 |
2004年 | 98篇 |
2003年 | 79篇 |
2002年 | 97篇 |
2001年 | 37篇 |
2000年 | 32篇 |
1999年 | 44篇 |
1998年 | 16篇 |
1997年 | 16篇 |
1996年 | 8篇 |
1995年 | 10篇 |
1994年 | 6篇 |
1993年 | 5篇 |
1992年 | 15篇 |
1991年 | 22篇 |
1990年 | 10篇 |
1989年 | 10篇 |
1988年 | 15篇 |
1987年 | 11篇 |
1986年 | 10篇 |
1985年 | 8篇 |
1984年 | 10篇 |
1983年 | 6篇 |
1981年 | 6篇 |
1980年 | 3篇 |
1979年 | 5篇 |
1975年 | 3篇 |
1973年 | 4篇 |
1972年 | 4篇 |
1969年 | 7篇 |
1965年 | 2篇 |
1933年 | 2篇 |
排序方式: 共有1754条查询结果,搜索用时 0 毫秒
1.
2.
Hatta Naohito MD PhD † Morita Reiji MD PhD Yamada Mizuki MD Takehara Kazuhiko MD PhD Ichiyanagi Kenji MD PhD ‡ Yokoyama Kunihiko MD PhD ‡ 《Dermatologic surgery》2005,31(3):327-330
BACKGROUND: Although there is lymphatic flow into the popliteal fossa from a skin tumor located in the lower leg, popliteal metastasis is extremely rare. Recently, sentinel lymph nodes outside traditional nodal basins have been identified. This study investigated the incidence of sentinel nodes in the popliteal region and the indication for biopsy. METHODS: Fourteen patients with various skin cancers involving the lower extremities (nine melanomas, four squamous cell carcinomas, and one sweat gland carcinoma) underwent lymphoscintigraphy and excision with sentinel lymph node biopsy. RESULTS: In all 14 patients, hot spots showed accumulation in the groin region. Five of 14 patients (36%) demonstrated popliteal sentinel nodes in addition to the inguinal nodes. Three of five popliteal sentinel nodes were histologically studied. A patient with acral melanoma demonstrated micrometastasis of melanoma cells in a popliteal node but not in the groin node. CONCLUSION: This study demonstrates that sentinel lymph nodes located in the popliteal fossa are frequently detected by lymphoscintigraphy and that biopsy should be performed if popliteal nodes are identified. 相似文献
3.
Hideyuki Iwai Ryuji Koike Jun Ogawa Takahiko Sugihara Hiroyuki Hagiyama Kenji Nagasaka Yoshinori Nonomura Junko Nishio Toshihiro Nanki Rieko Tsubata Hitoshi Kohsaka Tetsuo Kubota Nobuyuki Miyasaka 《Nihon Rinshō Men'eki Gakkai kaishi》2002,25(3):270-276
A 36-year-old man was admitted to a hospital with complaints of fever, polyarthralgia and dyspnea. Erythema was observed on his face, extensor surface of the fingers and extremities, and a chest X-ray revealed massive bilateral pleural effusion. He had no sign of myopathy at this point. Pleural fluid was proved to be exudative and contained extremely high levels of hyaluronic acid. He was also complicated with interstitial pneumonitis and was given a pulse therapy with methyl prednisolone followed by daily administration of 55 mg prednisolone (PSL). Twenty days after the commencement of the therapy, pleural effusion decreased but muscle weakness gradually appeared, accompanied by elevation of myogenic enzymes. Myogenic changes on electromyogram, and irregularity of the muscle fibers with slight inflammatory cell infiltrates in a biopsy specimen were demonstrated. He was transferred to our hospital, and a diagnosis of dermatomyositis was made. Later, pleural effusion waxed and waned depending on the dosage of PSL, but no other causative disorder was demonstrated by extensive examinations. This case indicates that the pleuritis could be one of the vasculitic manifestations of dermatomyositis. 相似文献
4.
5.
Fukui K Kominami R Kaneuji A Matsumoto T Shinohara H 《Okajimas folia anatomica Japonica》2004,81(4):57-62
We report a new method of perfusion fixation for the proximal one-third of the femur of the Japanese white rabbit. Fluids to flush the blood and fix the marrow were injected into the abdominal aorta and drained from the stump of the femur. The oozing of the fluids from the stumps guaranteed complete flushing and fixation. The new method facilitated fixation and decreased the volume of necessary fluids. Scanning electron microscopy (SEM) images of bone marrow fixed using the new method and using the conventional method did not differ. Large fat globules were not observed in the SEM specimens produced using either the new or the conventional method. 相似文献
6.
Effect of ascorbic acid on fibrinolysis 总被引:1,自引:0,他引:1
M Shimizu Y Hatta H Hayashi M Itokawa Y Yanagisawa 《Journal of Japan Haematological Society》1970,33(1):137-148
7.
Yamamoto A Honma R Sumita M Hanawa T 《Journal of biomedical materials research. Part A》2004,68(2):244-256
When artificial hip or knee joints are implanted in the human body, they release metallic, ceramic, and polymeric debris into the surrounding tissues. The toxicity of the released particles is of two types: chemical, caused by the released soluble ions and monomers, and mechanical, a result of mechanical stimulation produced by the insoluble particles. In this study, the cytotoxicity of particles of TiO2, Al2O3, ZrO2, Si3N4, and SiC for murine fibroblasts and macrophages were examined to evaluate just their mechanical toxicity because these particles are not expected to release soluble metal ions. Different sizes and shapes of TiO2 particles were used to evaluate the effect of size and shape on particle cytotoxicity. The results suggest that the cytotoxicity of ceramic particles does not depend on their chemical species. Cytotoxicity levels were lower than those of corresponding metal ions, indicating that the mechanical toxicity of particles is lower than the chemical toxicity of released soluble ions and monomers. The differences in size did not affect the mechanical toxicity of these particles. The dendritic particles had a higher cytotoxicity level for macrophages than did spindle and spheric particles. 相似文献
8.
Mirjam?I?BakkerEmail author Linda?May Mochammad?Hatta Agnes?Kwenang Paul?R?Klatser Linda?Oskam Jeanine?J?Houwing-Duistermaat 《BMC medical genetics》2005,6(1):40
Background
It is generally accepted that genetic factors play a role in susceptibility to both leprosy per se and leprosy type, but only few studies have tempted to quantify this. Estimating the contribution of genetic factors to clustering of leprosy within families is difficult since these persons often share the same environment. The first aim of this study was to test which correlation structure (genetic, household or spatial) gives the best explanation for the distribution of leprosy patients and seropositive persons and second to quantify the role of genetic factors in the occurrence of leprosy and seropositivity. 相似文献9.
This study concerns the immunohistochemical localization of S-100 alpha, S-100 beta, and whole brain S-100 (wbS-100) in testicular large-cell calcifying Sertoli cell tumor (LCCSCT). We examined 8 LCCSCTs (7 benign and 1 malignant), 6 Sertoli cell tumors not otherwise specified (SCTs-NOS), 6 Leydig cell tumors (LCTs), 5 ovarian Sertoli-Leydig cell tumors (SLCTs), and 7 gonadoblastomas (GBLs). The 8 LCCSCTs showed immunoreactivity for S-100 alpha, S-100 beta, and wbS-100. Five of the 6 LCTs and the Leydig cell components in the ovarian SLCTs stained positively for S-100 alpha and wbS-100 but were negative for S-100 beta. SCTs-NOS and the Sertoli cell components in the SLCTs occasionally showed focal and weak/moderate positivity for S-100 alpha, S-100 beta, and wbS-100. Sex cord cells of the GBLs were positive for S-100 beta and wbS-100 and negative for S-100 alpha. Germ cell elements of the GBLs were negative for S-100 alpha, S-100 beta, and wbS-100. In nonneoplastic testicular parenchyma adjacent to the above-mentioned tumors, there was S-100 alpha reactivity in Leydig cells, rete testis, and a few Sertoli cells. S-100 beta reactivity was seen in a few Sertoli cells, Schwann cells, and some endothelial cells. WbS-100 reactivity was present in Leydig cells, a few Sertoli cells, rete testis, Schwann cells, and some endothelial cells. The results indicate that S-100 alpha and S-100 beta can potentially be used as immunohistochemical markers for LCCSCT, especially when differentiating it from LCT, which may mimic LCCSCT on routine histopathology. Although the biological significance of both S-100 subunits expression in LCCSCT remains unknown, these notable calcium-binding proteins may be associated with the characteristic calcification in LCCSCT through regulation of calcium levels in the tumor cells. 相似文献
10.