全文获取类型
收费全文 | 500篇 |
免费 | 11篇 |
国内免费 | 3篇 |
专业分类
儿科学 | 7篇 |
妇产科学 | 6篇 |
基础医学 | 61篇 |
口腔科学 | 1篇 |
临床医学 | 60篇 |
内科学 | 66篇 |
皮肤病学 | 3篇 |
神经病学 | 47篇 |
特种医学 | 10篇 |
外科学 | 75篇 |
综合类 | 1篇 |
预防医学 | 111篇 |
眼科学 | 22篇 |
药学 | 31篇 |
中国医学 | 2篇 |
肿瘤学 | 11篇 |
出版年
2023年 | 4篇 |
2022年 | 8篇 |
2021年 | 21篇 |
2020年 | 3篇 |
2019年 | 13篇 |
2018年 | 13篇 |
2017年 | 12篇 |
2016年 | 11篇 |
2015年 | 5篇 |
2014年 | 16篇 |
2013年 | 33篇 |
2012年 | 43篇 |
2011年 | 61篇 |
2010年 | 30篇 |
2009年 | 27篇 |
2008年 | 32篇 |
2007年 | 36篇 |
2006年 | 25篇 |
2005年 | 20篇 |
2004年 | 27篇 |
2003年 | 27篇 |
2002年 | 18篇 |
2001年 | 8篇 |
2000年 | 1篇 |
1999年 | 1篇 |
1998年 | 1篇 |
1996年 | 2篇 |
1995年 | 1篇 |
1994年 | 1篇 |
1993年 | 1篇 |
1992年 | 2篇 |
1991年 | 2篇 |
1990年 | 1篇 |
1989年 | 3篇 |
1983年 | 3篇 |
1982年 | 2篇 |
排序方式: 共有514条查询结果,搜索用时 15 毫秒
1.
2.
Najet Rebai Guillermina Almazan Ling Wei Mark I. Greene H. Uri Saragovi 《The European journal of neuroscience》1996,8(2):273-281
A surface receptor complex of M r ˜65 000 (p65) and ˜95 000 (p95) is expressed in cells of the central nervous system of mice. This receptor is recognized by monoclonal antibody 87.92.6 or by reovirus type 3 haemagglutinin as unnatural ligands. The p65/p95 receptor is expressed mostly in neural embryonic precursors undergoing proliferation, especially those in the S-G2 phase of the cell cycle. Receptor expression decreases progressively throughout embryogenesis to low but detectable levels in the adult brain. Biochemical characterization revealed that the neural p65/p95 receptor complex is indistinguishable from the p65/p95 receptor expressed in T cells, where receptor ligation leads to a mitogenic block. In neural and lymphoid tissues the p65/p95 receptor (or an associated protein) possesses a tyrosine kinase enzymatic activity. Receptor ligation in neural cells resulted in the rapid tyrosine phosphorylation of cellular proteins which are different from substrates phosphorylated in T cells. Differential substrate coupling to the receptor may account for differences in signal transduction and biology between neural cells and T cells. Further study of this receptor complex may help define important features of neural proliferation, differentiation and survival. 相似文献
3.
Analysis of MHC genes in a Tunisian isolate with autoimmune thyroid diseases: implication of TNF -308 gene polymorphism 总被引:4,自引:0,他引:4
Bougacha-Elleuch N Rebai A Mnif M Makni H Bellassouad M Jouida J Abid M Hammadi A 《Journal of autoimmunity》2004,23(1):75-80
Autoimmune thyroid diseases (AITDs), which include Hashimoto thyroiditis (HT), Graves' disease (GD) and primary idiopathic myxoedema (PIM), are recognized as multifactorial diseases. In this study, we have examined single and haplotypic genetic variation across the major histocompatibility complex (MHC) in a Tunisian isolate with a high prevalence of AITDs (62 patients: 32 with GD, 9 with HT and 21 with PIM). Genotyping was performed for HLA class I and II alleles as well as polymorphisms within tumor necrosis factor (TNF), lymphotoxin alpha (TLalpha) and heat shock protein (HSP70-02 and HSP70-hom) genes. Our results showed association of HLA-A2-B50-TNF 2 haplotype with AITDs (p = 0.045). Linkage analysis using Simwalk2 program has shown significant result with TNF -308 gene polymorphism (p = 0.03). The FBAT has given evidence for genetic association with TNF -308 and HLA-DR gene polymorphisms. TNF 2 allele was associated with GD (p = 0.0011), whereas TNF 1, HLA-DR11 and DR12 (p = 0.0039, p = 0.00089 and p = 0.0056, respectively) were rather implicated in HT pathogenesis. Results found by TDT-STDT have confirmed the involvement of the TNF -308 gene polymorphism in AITD pathogenesis (p < 10(-9)). 相似文献
4.
Riadh Nciri Ezzeddine Bourogaa Samira Jbahi Mohamed Salah Allagui Abdelfattah Elfeki Christian Vincent Franoise Croute 《中国神经再生研究》2014,9(7):735-740
To investigate the molecular mechanism underlying the neuroprotective effect of lithium on cells, in this study, we exposed SH-SY5Y cells to 0.5 mmol/L lithium carbonate(Li2CO2) for 25–50 weeks and then detected the expression levels of some neurobiology related genes and post-translational modifications of stress proteins in SH-SY5Y cells. cDNA arrays showed that pyruvate kinase 2(PKM2) and calmodulin 3(CaM 3) expression levels were significantly down-regulated, phosphatase protein PP2A expression was lightly down-regulated, and casein kinase II(CK2), threonine/tyrosine phosphatase 7(PYST2), and dopamine beta-hydroxylase(DBH) expression levels were significantly up-regulated. Besides, western blot analysis of stress proteins(HSP27, HSP70, GRP78 and GRP94) showed an over-expression of two proteins: a 105 kDa protein which is a hyper-phosphorylated isoform of GRP94, and a 108 kDa protein which is a phosphorylated tetramer of HSP27. These results suggest that the neuroprotective effects of lithium are likely related to gene expressions and post-translational modifications of proteins cited above. 相似文献
5.
Ibtihel Rebai Ichraf Kraoua Hanene Benrhouma Aida Rouissi Ilhem Turki Irène Ceballos-Picot Neziha Gouider-Khouja 《Brain & development》2014
Lesch Nyhan syndrome (LNS) is an X-linked recessive disorder due to complete deficiency of the hypoxanthine–guanine phosphoribosyltransferase (HPRT) enzyme. Defect of the enzymatic activity is related to mutations of the HPRT1 gene. The disorder severity is due to neurological features and renal complications. Up to now, more than 300 mutations have been reported. We report on a Tunisian child with a severe phenotype due to a novel identified complex mutation. 相似文献
6.
7.
8.
9.
Abdellatif Maalej Fadhila Mbarki Ahmed Rebai Foued Karray Jomaa Jouida Mohamed Abid 《Autoimmunity》2013,46(3):237-239
FKBP1B belongs to immunophilins superfamily and functions as a cytosolic receptor protein of FK506. The role of FKBP1B in the immunosuppressive pathway of FK506 is well established. Previously, we reported a strong evidence of linkage between D2S171 microsatellite marker (located in vicinity of FKBP1B gene) and susceptibility to autoimmune thyroid diseases (AITDs). In this study, we report linkage disequilibrium between the dimorphism (C/T) in the 3′ untranslated region (3′ UTR) of FKBP1B gene and susceptibility to AITDs.DNAs were extracted from a large Tunisian family affected with Graves' disease (GD) and Hashimoto's thyroiditis (HT) and analysed by PCR–RFLP using DraIII restriction enzyme. Our results showed an excess of transmission of the allele C from heterozygous parents to affected offspring (transmission disequilibrium test (TDT)=4.76; p=0.012). This suggests a linkage disequilibrium of 3′ UTR (C/T) SNP with AITDs. Moreover, The FBAT analysis gives a significant association with the C allele under the recessive model (χ2=5.50; p=0.018). These results support the involvement of FKBP1B gene in the genetic susceptibility to the AITDs development in the studied family. 相似文献
10.
Maria Benito de Valle Tobias Müller Einar Björnsson Morgane Otten Martin Volkmann Olaf Guckelberger Bertram Wiedenmann Riadh Sadik Eckart Schott Mats Andersson Thomas Berg Björn Lindkvist 《Digestive and liver disease》2014,46(10):903-908