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Medication administration errors from a nursing viewpoint: a formal consensus of definition and scenarios using a Delphi technique 下载免费PDF全文
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Jennifer M. Logue Elisa Zucchetti Christina A. Bachmeier Gabriel S. Krivenko Victoria Larson Daniel Ninh Giovanni Grillo Biwei Cao Jongphil Kim Julio C. Chavez Aliyah Baluch Farhad Khimani Aleksandr Lazaryan Taiga Nishihori Hien D. Liu Javier Pinilla-Ibarz Bijal D. Shah Rawan Faramand Anna E. Coghill Marco L. Davila Bhagirathbhai R. Dholaria Michael D. Jain Frederick L. Locke 《Haematologica》2021,106(4):978
CD19 chimeric antigen receptor T (CAR T)-cell therapy with axicabtagene ciloleucel (axi-cel) for relapsed or refractory (R/R) large B-cell lymphoma (LBCL) may lead to durable remissions, however, prolonged cytopenias and infections may occur. In this single center retrospective study of 85 patients, we characterized immune reconstitution and infections for patients remaining in remission after axi-cel for LBCL. Prolonged cytopenias (those occurring at or after day 30 following infusion) were common with ≥grade 3 neutropenia seen in 21 of 70 (30%) patients at day 30 and persisting in 3 of 31 (9.7%) patients at 1 year. B cells were undetectable in 30 of 34 (88.2%) patients at day 30, but were detected in 11 of 19 (57.9%) at 1 year. Median immunoglobulin G levels levels reached a nadir at day 180. By contrast, CD4 T cells decreased from baseline and were persistently low with a median CD4 count of 155 cells/mL at 1 year after axi-cel (n=19, range: 33– 269). In total, 23 of 85 (27.1%) patients received intravenous immunoglobulins after axi-cel, and 34 of 85 (40%) received granulocyte-colony stimulating factor. Infections in the first 30 days occurred in 31 of 85 (36.5%) patients, of which 11 of 85 (12.9%) required intravenous antibiotics or hospitalization (“severe”) and were associated with cytokine release syndrome, neurotoxicity, tocilizumab use, corticosteroid use, and bridging therapy on univariate analyses. After day 30, seven severe infections occurred, with no late deaths due to infection. Prolonged cytopenias are common following axi-cel therapy for LBCL and typically recover with time. Most patients experience profound and prolonged CD4 T-cell immunosuppression without severe infection. 相似文献
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Lamyia Anweigi Rawan Noah Lujain Alessa Ebtissam Al-Madi Alhanoof Aldegheishem 《Saudi Dental Journal》2021,33(2):63-68
AimThe objective of the study was to assess the in vitro fracture resistance of endodontically treated teeth restored using different post-and-core materials.Materials and methodsExtracted human mandibular premolars (n = 36) were extracted teeth and equally distributed into four (4) treatment groups: cast metal post-and-core, milled zirconia post-and-core, pre-fabricated post with composite resin core and control group. These samples were then each subjected to the load to fracture test using a universal testing machine. Fracture resistance data were compared among groups by analysis of variance and Fisher’s exact test.ResultsThe highest mean fracture resistance value was observed in the zirconia post-and-core treatment group (1567.26 ± 317.66 N), followed by the cast metal (1355.92 ± 621.56 N) and lastly the pre-fabricated post with composite resin core (725.67 ± 251.05 N) treatment group. Differences among groups were not statistically significantly different (P = 3.77).ConclusionEndodontically treated mandibular premolars with a zirconia post-and-core system exhibited the highest robustness against structural failure based on its mean fracture resistance value. In addition, extracted teeth restored with cast post-and-core resisted a greater stress load than those restored with fiber-reinforced posts. Zirconia showed a more favorable fracture mode than the other restorations. 相似文献
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Al-Karaki Rawan Awadallah Areeg Tawfeek Hesham M. Nasr Maha 《Pharmaceutical Chemistry Journal》2020,53(12):1118-1121
Pharmaceutical Chemistry Journal - The work was aimed to elucidate whether the nanoencapsulation of oleuropein would potentiate its anticancer activity against colon cancer or not. Oleuropein... 相似文献
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Elewa Hazem Qurishi Iqrah Abouelhassan Rawan Abou Safrah Salam Alhamoud Eman Bader Loulia 《Journal of thrombosis and thrombolysis》2020,49(4):659-666
Journal of Thrombosis and Thrombolysis - There is no strong evidence on pharmacogenetics role on the quality of INR control after the initiation phase and on the maintenance of stable INR on the... 相似文献
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