全文获取类型
收费全文 | 9182篇 |
免费 | 592篇 |
国内免费 | 45篇 |
专业分类
耳鼻咽喉 | 166篇 |
儿科学 | 254篇 |
妇产科学 | 207篇 |
基础医学 | 1217篇 |
口腔科学 | 747篇 |
临床医学 | 829篇 |
内科学 | 1969篇 |
皮肤病学 | 199篇 |
神经病学 | 783篇 |
特种医学 | 268篇 |
外科学 | 1146篇 |
综合类 | 71篇 |
一般理论 | 2篇 |
预防医学 | 805篇 |
眼科学 | 133篇 |
药学 | 444篇 |
中国医学 | 46篇 |
肿瘤学 | 533篇 |
出版年
2023年 | 98篇 |
2022年 | 224篇 |
2021年 | 339篇 |
2020年 | 235篇 |
2019年 | 265篇 |
2018年 | 332篇 |
2017年 | 206篇 |
2016年 | 283篇 |
2015年 | 292篇 |
2014年 | 394篇 |
2013年 | 476篇 |
2012年 | 745篇 |
2011年 | 754篇 |
2010年 | 364篇 |
2009年 | 355篇 |
2008年 | 560篇 |
2007年 | 536篇 |
2006年 | 498篇 |
2005年 | 443篇 |
2004年 | 374篇 |
2003年 | 336篇 |
2002年 | 313篇 |
2001年 | 150篇 |
2000年 | 139篇 |
1999年 | 103篇 |
1998年 | 56篇 |
1997年 | 45篇 |
1996年 | 47篇 |
1995年 | 45篇 |
1994年 | 38篇 |
1993年 | 37篇 |
1992年 | 53篇 |
1991年 | 62篇 |
1990年 | 50篇 |
1989年 | 41篇 |
1988年 | 26篇 |
1987年 | 34篇 |
1986年 | 45篇 |
1985年 | 27篇 |
1984年 | 27篇 |
1983年 | 30篇 |
1982年 | 20篇 |
1981年 | 26篇 |
1980年 | 21篇 |
1978年 | 18篇 |
1977年 | 21篇 |
1975年 | 19篇 |
1974年 | 18篇 |
1972年 | 20篇 |
1970年 | 21篇 |
排序方式: 共有9819条查询结果,搜索用时 15 毫秒
1.
2.
3.
4.
5.
Raphael Mohr Robert Schierwagen Carolynne Schwarze-Zander Christoph Boesecke Jan-Christian Wasmuth Jonel Trebicka Jürgen Kurt Rockstroh 《Medicine》2015,94(50)
Liver-related death in human immunodeficiency virus (HIV)-infected individuals is about 10 times higher compared with the general population, and the prevalence of significant liver fibrosis in those with HIV approaches 15%. The present study aimed to assess risk factors for development of hepatic fibrosis in HIV patients receiving a modern combination anti-retroviral therapy (cART).This cross-sectional prospective study included 432 HIV patients, of which 68 (16%) patients were anti-hepatitis C virus (HCV) positive and 23 (5%) were HBsAg positive.Health trajectory including clinical characteristics and liver fibrosis stage assessed by transient elastography were collected at inclusion. Liver stiffness values >7.1 kPa were considered as significant fibrosis, while values >12.5 kPa were defined as severe fibrosis. Logistic regression and Cox regression uni- and multivariate analyses were performed to identify independent factors associated with liver fibrosis.Significant liver fibrosis was detected in 10% of HIV mono-infected, in 37% of HCV co-infected patients, and in 18% of hepatitis B virus co-infected patients. The presence of diabetes mellitus (odds ratio [OR] = 4.6) and FIB4 score (OR = 2.4) were independently associated with presence of significant fibrosis in the whole cohort. Similarly, diabetes mellitus (OR = 5.4), adiposity (OR = 4.6), and the FIB4 score (OR = 3.3) were independently associated with significant fibrosis in HIV mono-infected patients. Importantly, cumulative cART duration protected, whereas persistent HIV viral replication promoted the development of significant liver fibrosis along the duration of HIV infection.Our findings strongly indicate that besides known risk factors like metabolic disorders, HIV may also have a direct effect on fibrogenesis. Successful cART leading to complete suppression of HIV replication might protect from development of liver fibrosis. 相似文献
6.
Amanda Leal Rocha Alessandra Figueiredo De Souza Laiz Fernandes Mendes Nunes Nayara Dias de Souza Cunha Clia Regina Moreira Lanza Denise Vieira Travassos Tarcília Aparecida da Silva 《Pediatric dermatology》2019,36(1):e27-e30
Drug‐induced reactions are complications associated with high mortality and significant morbidity. Stevens–Johnson Syndrome (SJS) and toxic epidermal necrolysis (TEN) are examples of these conditions, which are characterized by skin and mucous lesions. Here, we report a case of a 9‐year‐old girl who presented with blisters associated with an extensive vesicular rash and multiple ulcerations on the lips and oral cavity. A drug‐induced hypersensitivity reaction to antibiotics was suspected, and a diagnosis of TEN was made. The patient was managed with withdrawal of the suspected causative agent, and the oral lesions were treated with low‐level laser therapy (LLLT) and oral hygiene. This case highlights that TEN requires interdisciplinary intervention with dental assistance and follow‐up to improve symptoms, nutrition, systemic condition, and quality of life. 相似文献
7.
F Lofaso F Nicot M Lejaille L Falaize A Louis A Clement J-C Raphael D Orlikowski B Fauroux 《The European respiratory journal》2006,27(5):980-982
Sniff nasal inspiratory pressure (SNIP) measurement is a volitional noninvasive assessment of inspiratory muscle strength. A maximum of 10 sniffs is generally used. The purpose of the present study was to investigate whether the maximum SNIP improved after the tenth sniff. In total, 20 healthy volunteers and 305 patients with various neuromuscular and lung diseases were encouraged to perform 40 and 20 sniffs, respectively. The best SNIP among the first 10 sniffs was lower than the best SNIP among the next 10 sniffs in the healthy volunteers and patients. The SNIP improvement after the twentieth sniff was marginal. In conclusion, a learning effect persists after the tenth sniff. The current authors suggest using 10 additional sniffs when the best result of the first 10 sniffs is slightly below normal, or when sniff nasal inspiratory pressure is used to monitor a progressive decline in inspiratory muscle strength. 相似文献
8.
Neil H Pliskin Alia N Ammar Joseph W Fink S Kristian Hill Aaron C Malina Alona Ramati Kathleen M Kelley Raphael C Lee 《Journal of the International Neuropsychological Society》2006,12(1):17-23
The clinical presentation of electrical injury commonly involves physical, cognitive, and emotional complaints. Neuropsychological studies, including case reports, have indicated that electrical injury (EI) survivors may experience a broad range of impaired neuropsychological functions, although this has not been clarified through controlled investigation. In this study, we describe the neuropsychological test findings in a series of 29 EI patients carefully screened and matched to a group of 29 demographically similar healthy electricians. Participants were matched by their estimated premorbid intellectual ability. Multivariate analysis of variance was used to assess group differences in the following neuropsychological domains: attention and mental speed, working memory, verbal memory, visual memory, and motor skills. EI patients performed significantly worse on composite measures of attention/mental speed and motor skills, which could not be explained by demographic differences, injury parameters, litigation status, or mood disturbance. Results suggest that cognitive changes do occur in patients suffering from electrical injury. 相似文献
9.
OBJECTIVE: Gelastic seizures are a frequent and well established manifestation of the epilepsy associated with hypothalamic hamartomas. The scalp EEG recordings very seldom demonstrate clear spike activity and the information about the ictal epilepsy dynamics is limited. In this work, we try to isolate epileptic rhythms in gelastic seizures and study their generators. METHODS: We extracted rhythmic activity from EEG scalp recordings of gelastic seizures using decomposition in independent components (ICA) in three patients, two with hypothalamic hamartomas and one with no hypothalamic lesion. Time analysis of these rhythms and inverse source analysis was done to recover their foci of origin and temporal dynamics. RESULTS: In the two patients with hypothalamic hamartomas consistent ictal delta (2-3 Hz) rhythms were present, with subcortical generators in both and a superficial one in a single patient. The latter pattern was observed in the patient with no hypothalamic hamartoma visible in MRI. The deep generators activated earlier than the superficial ones, suggesting a consistent sub-cortical origin of the rhythmical activity. CONCLUSIONS: Our data is compatible with early and brief epileptic generators in deep sub-cortical regions and more superficial ones activating later. SIGNIFICANCE: Gelastic seizures express rhythms on scalp EEG compatible with epileptic activity originating in sub-cortical generators and secondarily involving cortical ones. 相似文献
10.
Qin Lu Jean-Michel Constantin Ania Nieszkowska Marilia Elman Silvia Vieira Jean-Jacques Rouby 《Critical care (London, England)》2006,10(3):R95-10