全文获取类型
收费全文 | 1899篇 |
免费 | 106篇 |
国内免费 | 6篇 |
专业分类
耳鼻咽喉 | 23篇 |
儿科学 | 132篇 |
妇产科学 | 24篇 |
基础医学 | 186篇 |
口腔科学 | 45篇 |
临床医学 | 130篇 |
内科学 | 377篇 |
皮肤病学 | 37篇 |
神经病学 | 240篇 |
特种医学 | 47篇 |
外科学 | 294篇 |
综合类 | 39篇 |
一般理论 | 1篇 |
预防医学 | 57篇 |
眼科学 | 101篇 |
药学 | 131篇 |
中国医学 | 19篇 |
肿瘤学 | 128篇 |
出版年
2023年 | 14篇 |
2022年 | 28篇 |
2021年 | 75篇 |
2020年 | 50篇 |
2019年 | 41篇 |
2018年 | 71篇 |
2017年 | 50篇 |
2016年 | 55篇 |
2015年 | 62篇 |
2014年 | 67篇 |
2013年 | 83篇 |
2012年 | 162篇 |
2011年 | 122篇 |
2010年 | 72篇 |
2009年 | 63篇 |
2008年 | 129篇 |
2007年 | 107篇 |
2006年 | 84篇 |
2005年 | 66篇 |
2004年 | 79篇 |
2003年 | 53篇 |
2002年 | 62篇 |
2001年 | 40篇 |
2000年 | 43篇 |
1999年 | 47篇 |
1998年 | 15篇 |
1997年 | 15篇 |
1996年 | 4篇 |
1995年 | 5篇 |
1993年 | 4篇 |
1992年 | 21篇 |
1991年 | 15篇 |
1990年 | 23篇 |
1989年 | 22篇 |
1988年 | 19篇 |
1987年 | 11篇 |
1986年 | 20篇 |
1985年 | 10篇 |
1984年 | 11篇 |
1983年 | 15篇 |
1982年 | 10篇 |
1981年 | 7篇 |
1979年 | 13篇 |
1978年 | 5篇 |
1977年 | 6篇 |
1976年 | 5篇 |
1972年 | 5篇 |
1970年 | 3篇 |
1969年 | 3篇 |
1966年 | 3篇 |
排序方式: 共有2011条查询结果,搜索用时 15 毫秒
1.
2.
Neetu Radhakrishnan M.D. Chong. H. Park M.D. Barry M. Kaplan M.D. F.A.C.C. Rajiv Jauhar M.D. F.A.C.C. 《The International journal of angiology》2006,15(1):37-42
A 65-year-old man developed acute limb ischemia, severe abdominal wall and lower limb livedo reticularis following a coronary
angiogram. The differential diagnoses of acute limb ischemia and multiple cholesterol emboli syndrome (MCES) are discussed.
This work was performed at Long Island Jewish Medical Center, 270-05, 76th Avenue, New Hyde Park, NY 11040. 相似文献
3.
4.
A. Ravikumar S. Mohanty R. P. Vatsanath S. Raghunandhan 《Indian journal of otolaryngology and head and neck surgery》2004,56(4):317-320
The co-existence of fungal elements in allergic nasal Polyposis, has given rise to a distinct clinical entity known as ‘Allergic
fungal sinusitis ’ (AF’S). Many a time, these fungal elements may not be diagnosed pre-operatively by routine diagnostic nasal
endoscopy or CT scan of paranasal sinuses, due to the florid presentation of nasal polyps, which usually obscure the underlying
fungal pathology. The diagnosis is often made intra-operatively. The post-operative confirmation of AFS is by histopathology,
fungal smear, fungal culture, allergic murin study and fungal specific IgE titres. We report a series often such cases done
in our institution, which highlight that AFS should be considered as a differential diagnosis in Sinonasal Polyposis cases,
for their effective management. 相似文献
5.
P. Subashini Dr. A. Ravikumar M.S. DNB DLORCS M. S. Ranjit V. K. Sairam R. P. Vatsanath S. Jayasree 《Indian journal of otolaryngology and head and neck surgery》2007,59(1):73-75
A two and half year old male child was seen with systemic hypertension, left ventricular dysfunction, mitral regurgitation and congestive cardiac failure. Examination revealed adenoid hypertrophy. He was also suffering from obstructive sleep apnea. He was being treated with anti-hypertensive and anti-failure drugs. Adenoidectomy was performed following which obstructive sleep apnea symptoms disappeared and his cardiac status improved markedly. Subsequently he was weaned off anti-hypertensive and anti-failure therapy. 相似文献
6.
7.
Intradural cavernomas are rare vascular lesions of the spinal cord. Four cases of histologically verified cavernomas of the cord are reported, of which two were extramedullary and two were intramedullary in location. Progressive neurological deficit was the presenting feature in three cases while one patient had a rapid evolution of neurological deficits and was found at surgery to have had bled from the extramedullary lesion. All the patients were subjected to surgery and total excision of the cavernomas was carried out in each case. While two patients improved after surgery the other two remained static. The available literature on spinal cord cavernomas is reviewed. 相似文献
8.
M V Beheshti D F Denny M G Glickman W Bodden J C Marsh R Strair T S Ravikumar 《Journal of vascular and interventional radiology : JVIR》1992,3(3):453-458
Chemotherapy for primary or metastatic hepatic malignancy is limited by poor tumor response and dose-related systemic toxicity. As an alternative to chemotherapy infusion by vein or by the hepatic artery, the authors have developed a percutaneous technique of isolated liver perfusion that allows the regional delivery of high-dose chemotherapy to the liver with little systemic toxicity. After placement of a hepatic artery infusion catheter, an 18-F double-balloon catheter is placed into the inferior vena cava through the opposite femoral vein. Balloons are inflated above and below the hepatic veins, thus isolating hepatic venous outflow. The effluent passes through fenestrations in the catheter and is pumped through charcoal hemoperfusion filters where the drug is removed. The filtered blood is returned to the patient through the internal jugular vein. Fifteen treatments have been conducted in eight patients in a phase I dose-escalation study with use of 5-fluorouracil (5-FU). While it is premature to assess tumor response to isolated liver perfusion, the data demonstrate that the procedure is safe and is tolerated by patients. Pharmacokinetic studies show a 5-FU extraction of up to 85%, with minimal drug leakage into the systemic circulation. This technique shows potential for improving liver tumor response while decreasing systemic toxicity. 相似文献
9.
Leukoerythrophagocytosis by sinus histiocytes in the lymph nodes is a rare cytological observation. Though often seen in lymph nodes draining malignancies, one may occasionally encounter them in vascular lesions. We report a case of leukoerythrophagocytosis by sinus histiocytes of the right supraclavicular lymph nodes in a 35-yr-old male. He presented with a painful soft tissue mass in the right anterior region of the chest wall extending into the axilla of 6 mo duration. Bilateral radial pulsations were absent. The patient had received treatment for pulmonary tuberculosis 1 yr ago. FNAC of the soft tissue mass revealed only blood. Radiological evaluation revealed a vascular lesion, with smooth borders, extending into the upper zone of right lung and displacing the second rib inferiorly. Doppler evaluation confirmed it to be a right subclavian aneurysm with arteritis. 相似文献
10.
Inhibition of Prostate Cancer Cell Colony Formation by the Flavonoid Quercetin Correlates with Modulation of Specific Regulatory Genes
下载免费PDF全文
![点击此处可从《Clinical and Vaccine Immunology : CVI》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Hari Krishnan Nair Kesava V. K. Rao Ravikumar Aalinkeel Supriya Mahajan Ram Chawda Stanley A. Schwartz 《Clinical and Vaccine Immunology : CVI》2004,11(1):63-69
The natural product quercetin is a flavonoid found in many fruits and vegetables. Previous research has shown that quercetin has antitumor, anti-inflammatory, antiallergic, and antiviral activities. In the present investigation we studied the effect of quercetin on the ability of prostate cancer cell lines with various degrees of aggressive potential to form colonies in vitro. Specifically, we examined the molecular mechanisms underlying this effect, including the expression of cell cycle and tumor suppressor genes as well as oncogenes. We observed that quercetin at concentrations of 25 and 50 μM significantly inhibited the growth of the highly aggressive PC-3 prostate cancer cell line and the moderately aggressive DU-145 prostate cancer cell line, whereas it did not affect colony formation by the poorly aggressive LNCaP prostate cancer cell line or the normal fibroblast cell line BG-9. Using the gene array methodology, we found that quercetin significantly inhibited the expression of specific oncogenes and genes controlling G1, S, G2, and M phases of the cell cycle. Moreover, quercetin reciprocally up-regulated the expression of several tumor suppressor genes. In conclusion, our results demonstrate that the antitumor effects of quercetin directly correlate with the aggressive potential of prostate cancer cells and that the mechanism(s) of quercetin-mediated antitumor effects may involve up-regulation of tumor suppressor genes and reciprocal down-regulation of oncogenes and cell cycle genes. The results of these studies provide a scientific basis for the potential use of flavonoids as nutraceuticals in the chemoprevention of cancer. 相似文献