全文获取类型
收费全文 | 110039篇 |
免费 | 6333篇 |
国内免费 | 3269篇 |
专业分类
耳鼻咽喉 | 597篇 |
儿科学 | 3513篇 |
妇产科学 | 3873篇 |
基础医学 | 9124篇 |
口腔科学 | 2507篇 |
临床医学 | 10831篇 |
内科学 | 21551篇 |
皮肤病学 | 1204篇 |
神经病学 | 5266篇 |
特种医学 | 4210篇 |
外国民族医学 | 5篇 |
外科学 | 9272篇 |
综合类 | 15565篇 |
现状与发展 | 1篇 |
一般理论 | 17篇 |
预防医学 | 11431篇 |
眼科学 | 2941篇 |
药学 | 6915篇 |
5篇 | |
中国医学 | 5158篇 |
肿瘤学 | 5655篇 |
出版年
2023年 | 703篇 |
2022年 | 676篇 |
2021年 | 1026篇 |
2020年 | 903篇 |
2019年 | 558篇 |
2018年 | 1325篇 |
2017年 | 1262篇 |
2016年 | 1443篇 |
2015年 | 1475篇 |
2014年 | 1666篇 |
2013年 | 2302篇 |
2012年 | 4471篇 |
2011年 | 7621篇 |
2010年 | 3967篇 |
2009年 | 2991篇 |
2008年 | 5353篇 |
2007年 | 5082篇 |
2006年 | 4843篇 |
2005年 | 5999篇 |
2004年 | 10606篇 |
2003年 | 9971篇 |
2002年 | 7767篇 |
2001年 | 6234篇 |
2000年 | 3305篇 |
1999年 | 3829篇 |
1998年 | 2824篇 |
1997年 | 2433篇 |
1996年 | 1646篇 |
1995年 | 1390篇 |
1994年 | 1466篇 |
1993年 | 2012篇 |
1992年 | 1862篇 |
1991年 | 1646篇 |
1990年 | 1317篇 |
1989年 | 1169篇 |
1988年 | 925篇 |
1987年 | 818篇 |
1986年 | 778篇 |
1985年 | 480篇 |
1984年 | 329篇 |
1983年 | 260篇 |
1982年 | 204篇 |
1981年 | 187篇 |
1980年 | 146篇 |
1979年 | 209篇 |
1978年 | 159篇 |
1977年 | 151篇 |
1975年 | 156篇 |
1974年 | 141篇 |
1973年 | 160篇 |
排序方式: 共有10000条查询结果,搜索用时 0 毫秒
1.
2.
3.
María Cabrerizo Gloria Trallero María José Pena Amaia Cilla Gregoria Megias Carmen Mu?oz-Almagro Eva Del Amo Diana Roda Ana Isabel Mensalvas Antonio Moreno-Docón Juan García-Costa Nuria Rabella Manuel Ome?aca María Pilar Romero Sara Sanbonmatsu-Gámez Mercedes Pérez-Ruiz María José Santos-Mu?oz Cristina Calvo And the study group of “Enterovirus parechovirus infections in children under ?years-old Spain” PI- 《European journal of pediatrics》2015,174(11):1511-1516
4.
5.
Bi-Hua BIE Yong CHEN Zhi-Qi ZHAO Institute of Neurobiology Fu-Dan University Shanghai China Institute of Shanghai Physiology Chinese Academy of Sciences Shanghai China 《中国神经科学杂志》2006,(2)
Objective Ligustrazine, also named as tetramethylpyrazine, is a compound purified from Ligusticum chuanxiong hort and has ever been testified to be a calcium antagonist. The present investigation was to determine the antinoci-ceptive effect of ligustrazine and, if any, the peripheral ionic mechanism involved. Methods Paw withdrawal Latency ( PWL) to noxious heating was measured in vivo and whole-cell patch recording was performed on small dorsal root ganglion (DRG) neurons. Results Intraplantar injection of ligustrazine (0.5 mg in 25μl) significantly prolonged the withdrawal latency of ipsilateral hindpaw to noxious heating in the rat. Ligustrazine not only reversibly inhibited high-voltage gated calcium current of dorsal root ganglion (DRG) neuron in dose-dependent manner with IC50 of 1.89 mmol/L, but also decreased tetrodotoxin (TTX) -resistant sodium current in relatively selective and dose-dependent manner with IC50 of 2.49 mmol/L. Conclusion The results suggested that ligustrazine could elevate the threshold of thermal nociception through inhibiting the high-voltage gated calcium current and TTX-resistant sodium current of DRG neuron in the rat. 相似文献
6.
GIUSEPPE BORIANI MAURO BIFFI MAURIZIO RUSSO† MAURIZIO LUNATI‡ GIANLUCA BOTTO¶ ALESSANDRO PROCLEMER§ GIUSEPPE VERGARA WERNER RAHUE†† CRISTIAN MARTIGNANI RENATO RICCI† MASSIMO SANTINI† On Behalf of the SEARCH MI Registry Italian Investigators 《Pacing and clinical electrophysiology : PACE》2006,29(S2):S29-S34
Background: Large randomized trials show that in appropriately selected patients with left ventricular dysfunction, implantable cardioverter-defibrillators (ICDs) can improve overall survival at 2–5 years. Since direct implementation of the criteria used in the MADIT II and SCD-HeFT will lead to a marked rise in ICD implants, there is a growing fear that increased use of ICDs may cause a dramatic burden to health care systems. The ICD has traditionally been seen as an expensive form of treatment, which is difficult to accept at the first look. This is mainly due to the nonlinear character of the ICD investment, characterized by high initial expenditure, followed by a deferred pay-off in terms of clinical benefits. Cost-effectiveness analysis may help provide a different perspective on the problem of ICD cost, as may estimation of the daily cost of ICD treatment, assuming a time horizon of 5–7 years—a particularly interesting subject for further registry studies.
Methods and Results: Based on real expenditure data from 2002 to 2005, as recorded in the Search-MI Registry-Italian Sub-study of patients implanted on MADIT II indications, we estimated the daily costs associated with the device and leads. Over a 5–7 year time horizon, the average daily cost was estimated to be €4.60–€6.70. Translation of these figures into U.S. market conditions suggests a daily cost of around $7.90–$11.40.
Conclusions: These findings appear useful to help evaluate the affordability of ICD in comparison with other therapeutic options in a context of limited available economic resources. 相似文献
Methods and Results: Based on real expenditure data from 2002 to 2005, as recorded in the Search-MI Registry-Italian Sub-study of patients implanted on MADIT II indications, we estimated the daily costs associated with the device and leads. Over a 5–7 year time horizon, the average daily cost was estimated to be €4.60–€6.70. Translation of these figures into U.S. market conditions suggests a daily cost of around $7.90–$11.40.
Conclusions: These findings appear useful to help evaluate the affordability of ICD in comparison with other therapeutic options in a context of limited available economic resources. 相似文献
7.
8.
9.
Avninder Dhaliwal Adrienne L West Jonathan D Trobe David C Musch 《Journal of neuro-ophthalmology》2006,26(1):4-10
BACKGROUND: The relationship between the circumstances and severity of closed head injury (CHI) and the clinical and imaging features of cranial nerve 3, 4, and 6 palsies has not been rigorously addressed in a large study. METHODS: Retrospective chart review of 210 consecutive patients with CHI examined at a single tertiary care center from 1987 to 2002. Patients were located by searching the ophthalmology inpatient consultation and neuro-ophthalmology outpatient databases and hospital emergency room billing codes for a diagnosis of traumatic 3, 4, or 6 cranial nerve palsy (Cranial Nerve Injury Group) and a diagnosis of CHI without traumatic 3, 4, or 6 nerve palsy (Control Group). The Cranial Nerve Injury Group was then subdivided into two groups: those with injuries to an individual cranial nerve and those with multiple (including bilateral) cranial nerve injuries. Comparisons between groups were based on age, gender, type of accident, Glasgow Coma Scale (GCS), documented loss of consciousness (LOC), type of ocular injury, presence of systemic injury, need for rehabilitation, physical therapy and cognitive scores, and imaging features. RESULTS: The Cranial Nerve Injury Group had a significantly higher severity of head injury, more CT abnormalities, and worse short-term neurologic outcomes as compared with the Control Group. These trends were also found when each cranial nerve injury subgroup was compared with the Control Group. Those with cranial nerve 3 palsy had the most severe head injury; those with cranial nerve 4 palsy had an intermediate level of head injury; and those with cranial nerve 6 palsy had the lowest level of head injury. There were no consistent associations between the location of the imaging abnormalities and which cranial nerve was damaged. CONCLUSIONS: CHI with palsy of an ocular motor nerve was more severe than CHI without ocular motor nerve palsy, as measured by the GCS, intracranial and skull imaging abnormalities, and a greater frequency of inpatient rehabilitation. Palsy of cranial nerve 3 was associated with relatively more severe CHI than was palsy of cranial nerves 4 or 6. The location of the imaging abnormalities did not correlate with a particular cranial nerve injury. 相似文献
10.