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A randomized controlled trial of sedation in the critically ill 总被引:2,自引:0,他引:2
LYNN PARKINSON RSCN JULIE HUGHES RSCN REA GILL MSc IMOGEN BILLINGHAM BM FRCA JANE RATCLIFFE MB ChB FRCP & IMTI CHOONARA MD MRCP 《Paediatric anaesthesia》1997,7(5):405-510
A randomized controlled trial comparing: a) a combination of oral chloral hydrate and promethazine to b) a continuous intravenous midazolam infusion, for maintenance sedation in critically ill children, was carried out. The level of sedation was assessed four hourly using a specifically devized sedation scale. Forty-four children entered the study of whom two were subsequently excluded. The number of satisfactory assessments (desired and actual levels of sedation equal) was significantly greater in the chloral hydrate and promethazine group (Chi-squared P <0.01; confidence intervals of the difference 0.06 to 0.20). The number of assessments at level 5 on the sedation scale (patient restless/distressed) was significantly greater in the midazolam group (Chi-squared P <0.05). The total number of satisfactory assessments in the two groups were only 61 and 48% respectively, suggesting that sedation can be considerably improved. Chloral hydrate and promethazine are more effective than midazolam as maintenance sedation in critically ill children. It is possible to prospectively study the efficacy of sedative drugs in critically ill children. 相似文献
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Self-healing juvenile cutaneous mucinosis is characterized by an early age of onset, the presence of plaques and nodules in a characteristic distribution, and rapid onset followed by spontaneous resolution of the lesions within a period of weeks to months. Only four previous cases have been reported. The patient in this study was an 8-year-old child who developed cutaneous mucinosis while undergoing chemotherapy for a nephroblastoma, This is the first case described of self-healing juvenile cutaneous mucinosis associated with a neoplasm. 相似文献
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Lack of Influence of Atrioventricular Delay on Stroke Volume at Rest in Patients with Complete Atrioventricular Block and Dual Chamber Pacing 总被引:1,自引:0,他引:1
ERALDO OCCHETTA CRISTINA PICCININO GABRIELLA FRANCALACCI REA MAGNANI LEONARDO BOLOGNESE PAOLO DEVECCHI GIORGIO ROGNONI PAOLO ROSSI 《Pacing and clinical electrophysiology : PACE》1990,13(7):916-926
Dual chamber pacing (DDD) maintains atrioventricular (AV) sequence; AV delay programmability modifies the relationship between atrial and ventricular contraction. To evaluate the hemodynamic effects of such a modification, ten patients with a DDD unit for complete AV block were studied by time-motion (M-mode) and Doppler echocardiography during inhibited ventricular pacing (VVI), atrial-triggered ventricular pacing (VDD) and atrioventricular sequential pacing (DVI) at different AV delay (90, 140, 190, 240 msec). A significant improvement in stroke volume (SV) (15%-20%, P less than 0.05) was seen during DDD versus VVI pacing; no changes, however, were observed in the same patient with different AV delay or during DVI versus VDD pacing. These data suggest that programming of AV delay does not affect systolic performance at rest; longer diastolic filling times recorded during DDD pacing with "short" AV delay (90-140 msec) do not seem to be a hemodynamically relevant epi-phenomenon of PM programming. 相似文献
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Ventricular Tachycardia/Ventricular Fibrillation Ablation in the Setting of Ischemic Heart Disease 总被引:1,自引:0,他引:1
FRANCIS MARCHLINSKI M.D. FERMIN GARCIA M.D. AMIR SIADATAN M.D. WILLIAM SAUER M.D. STUART BELDNER M.D. ERICA ZADO P.A.-C. HENRY HSIA M.D. DAVID LIN M.D. JOSHUA COOPER M.D. RALPH VERDINO M.D. EDWARD GERSTENFELD M.D. SANJAY DIXIT M.D. REA RUSSO M.D. DAVID CALLANS M.D. 《Journal of cardiovascular electrophysiology》2005,16(S1):S59-S70
Recurrent ventricular tachycardia (VT) in the setting of coronary artery disease is frequently a life-threatening electrophysiologic emergency. Even in patients with an implantable defibrillator, recurrent VT is frequently accompanied by repeated and disabling shock therapy. Catheter ablative therapy offers the ability to provide immediate control of recurrent VT. Long-term elimination of VT should be anticipated in most patients. This article reviews the strategies, tools, techniques, and expected outcome for catheter ablation of stable and unstable ventricular arrhythmias in the setting ischemic heart disease. 相似文献
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CATHRIN THEIS M.D. HANKE MOLLNAU M.D. SEBASTIAN SONNENSCHEIN M.D. TORSTEN KONRAD M.D. EWALD HIMMRICH M.D. KARSTEN BOCK M.D. EBERHARD SCHULZ M.D. DENISE KÄMPFNER M.D. SIMON GERHARDT M.D. BLANCA QUESADA OCETE M.D. THOMAS MÜNZEL M.D. THOMAS ROSTOCK M.D. 《Journal of cardiovascular electrophysiology》2014,25(8):889-895
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ABSTRACT. The association of zinc and vitamin A levels was studied in liver of foetuses and infants which were stillborn or died of various causes between the age of 26 weeks of gestation up to 16 weeks post-partum. No correlation between zinc and vitamin A was observed ( r =0.07). Although smaller infants had more hepatic vitamin A than larger infants no significant difference was observed between these groups for liver zinc values. 相似文献