Predicting outcome in severe heart failure. Who will benefit from device therapy (CRT)?

Dyssynchronous ventricular contraction in severe heart failurecontributes to low cardiac output, worsening symptoms, and poorprognosis. Recognition of the effect of dyssynchrony in heartfailure, and the possibility of manipulating the sequence ofelectrical cardiac activation to improve the efficiency of mechanicalevents, led Cazeau et al. to attempt four-chamber pacing in1994.¹ This early system could stimulate both atria and bothventricles extrinsically, and could dictate the temporal relationshipbetween atrial systole and ventricular systole, and the ventriculo-ventricularrelationship. Modern cardiac resynchronization therapy (CRT),involving pacing of the right and left ventricles, with rightatrial pacing to optimize atrio-ventricular delay, has evolvedrapidly from this beginning. Left bundle branch block (LBBB) on the surface electrocardiogram(ECG) has been considered a marker of mechanical dyssynchronyas it represents a delay in conduction of depolarization tothe left ventricle, with the greatest delay usually being in     

The anti-arrhythmia properties of bonnecor metabolites

The experiments on the model of aconitine-induced arrhythmia in anesthetized rats and awake dogs with cardiac rhythm disorders caused by the coronary artery occlusion showed that all four metabolites of bonnecor possessed the antiarrhythmic activity. Metabolite 4 proved to be the most active on both models of cardiac rhythm disorders.     

Illness cognitions and health-related quality of life in liver transplant patients related to length of stay,comorbidities and complications

Quality of Life Research - Illness cognitions regarding helplessness and acceptance are known to play a role in health-related quality of life (HRQoL). Our study examined the evolution of these...     

Factors Associated with Nodal Pathologic Complete Response Among Breast Cancer Patients Treated with Neoadjuvant Chemotherapy: Results of CALGB 40601 (HER2+) and 40603 (Triple-Negative) (Alliance)

Annals of Surgical Oncology - De-escalation of axillary surgery after neoadjuvant chemotherapy (NAC) requires careful patient selection. We seek to determine predictors of nodal pathologic complete...     

Mast cell number,histamine concentration and placental vascular response to histamine in preeclampsia

Inflammation Research -     

19. Radiologische Diagnostik und Strahlentherapie

Zusammenfassung Diagnostische Verfahren wie Xeroradiographie, Lymphographie, Angio graphie und Computer-Tomographie können wertvolle Hinweise zur Indikation und den technischen Modalitäten einer chirurgischen Intervention bei malignen Weichteiltumoren geben. Der Strahlentherapie kommt im Rahmen der Behandlung von Fibro-, Lipo-, Leiomyo-, Synovialsarkomen, von malignen Schwannomen und Mesenchymomen im allgemeinen nur eine adjuvante|r" Rolle zu. Bei malignen Hämangio-Endotheliomen und -Pericytomen hat sie ihren festen Platz im Therapiekonzept.     

Place de la vaccination antipapillomavirus après 25 ans

Antipapillomavirus vaccination of young girls before their first sexual encounter is now a common practice. However, this prophylactive measure could also be extended to older patients. The HPV infection is indeed not limited to teenagers even if the highest incidence rate is noticed between the age of 18 and 30, it can also be found in older women. These older women show a sustained prevalence due to the longer persistence of the infection. This is clearly illustrated by the incidence of cervical cancer after the age of 50. Moreover, phase 3 studies in large unselected populations have shown the effectiveness of HPV vaccination in patients who had previously been infected by HPV (and got cured of it) as well as with patients who had never had any papillomavirus contact. Actually, less than 1 % of women who present simultaneously a HPV 16 and a HPV 18 infection will not derive any benefit from a HPV vaccination. Therefore, it seems logical to positively consider a HPV prophylaxis in patients who are above the age of 25 and who do not present any papillomavirus induced cervical lesion.     

Aggressive angiomyxoma of the vulva: a case report and review of literature

Background Aggressive angiomyxoma (AA) is a rare vulvovaginal mesenchymal neoplasm with a marked tendency to local recurrence but which usually does not metastasize. Case report We describe a case of AA in the left labium majus pudendi in a 47-year-old woman who underwent incomplete surgical excision. Follow-up 2 years later revealed no recurrence. Conclusion In the past, most authors advocated wide excision even if genitourinary and digestive tract resection were necessary. These days, a less radical surgery is recommended, but the significance of hormonal treatment and/or radiation therapy is not clear yet. Further investigation is necessary.