全文获取类型
收费全文 | 899篇 |
免费 | 57篇 |
国内免费 | 6篇 |
专业分类
耳鼻咽喉 | 8篇 |
儿科学 | 62篇 |
妇产科学 | 6篇 |
基础医学 | 79篇 |
口腔科学 | 9篇 |
临床医学 | 38篇 |
内科学 | 146篇 |
皮肤病学 | 7篇 |
神经病学 | 118篇 |
特种医学 | 76篇 |
外科学 | 212篇 |
综合类 | 87篇 |
预防医学 | 21篇 |
眼科学 | 6篇 |
药学 | 28篇 |
中国医学 | 1篇 |
肿瘤学 | 58篇 |
出版年
2021年 | 3篇 |
2020年 | 2篇 |
2019年 | 12篇 |
2018年 | 10篇 |
2017年 | 5篇 |
2016年 | 7篇 |
2015年 | 12篇 |
2014年 | 21篇 |
2013年 | 28篇 |
2012年 | 23篇 |
2011年 | 31篇 |
2010年 | 31篇 |
2009年 | 40篇 |
2008年 | 35篇 |
2007年 | 38篇 |
2006年 | 32篇 |
2005年 | 43篇 |
2004年 | 44篇 |
2003年 | 45篇 |
2002年 | 38篇 |
2001年 | 25篇 |
2000年 | 34篇 |
1999年 | 44篇 |
1998年 | 42篇 |
1997年 | 25篇 |
1996年 | 28篇 |
1995年 | 14篇 |
1994年 | 25篇 |
1993年 | 17篇 |
1992年 | 15篇 |
1991年 | 14篇 |
1990年 | 18篇 |
1989年 | 14篇 |
1988年 | 18篇 |
1987年 | 8篇 |
1986年 | 12篇 |
1985年 | 12篇 |
1984年 | 13篇 |
1983年 | 8篇 |
1982年 | 4篇 |
1981年 | 2篇 |
1980年 | 7篇 |
1979年 | 5篇 |
1978年 | 13篇 |
1977年 | 12篇 |
1976年 | 8篇 |
1975年 | 6篇 |
1974年 | 4篇 |
1972年 | 5篇 |
1968年 | 3篇 |
排序方式: 共有962条查询结果,搜索用时 15 毫秒
1.
HUGH F. MOLLOY F.A.C.D. ERIC LAMONT-GREGORY M.SC. CHRIS IDZIKOWSKI PH.D. F.B.PS.S. TERENCE J. RYAN D.M. F.R.C.P. 《International journal of dermatology》1993,32(9):668-672
Background. Extensive questioning of patients with a wide variety of skin disorders led to the impression that nocturnal overheating was probably an important factor in the initiation and the perpetuation of many skin disorders. Methods. In order to test the hypothesis, 12 “clean-skinned” subjects (6M/6F) aged 18 to 45 years were monitored electronically every 30 seconds during an 8 hour sleep period (2300 to 0700 hours), sleeping under a standard 10 tog duvet. Results. All the subjects were too hot by 3 to 4°C. All showed changes in their EEG patterns with reduced REM sleep, increased awakenings, and all showed changes in their sleep stage patterns. In addition, they all showed evidence of increased sweating in the “heat-sink” area. Conclusions. The mechanisms where by such changes could be implicated in the precipitation and perpetuation of skin disease are discussed. “Lifestyle” modification as a very effective, noninvasive, therapeutic regime is recommended. Further research along these lines would probably be very valuable and instructive. 相似文献
2.
3.
4.
5.
M Walter C G McDonald B W Paty A M J Shapiro E A Ryan P A Senior 《Diabetic medicine》2007,24(2):161-165
AIMS: Autoimmune diseases such as Addison's or coeliac disease can contribute to hypoglycaemia or malabsorption and are more common in Type 1 diabetes (T1DM). This brief report describes the prevalence of known and newly detected autoimmune disease in clinical islet transplant candidates with longstanding T1DM and severe hypoglycaemia and/or glycaemic lability who are routinely screened for coexisting autoimmune disease. METHODS: One hundred and twenty-four C-peptide negative T1DM subjects [77 (62%) female, mean age 44 +/- 9 years, diabetes duration 28 +/- 11 years, body mass index 24.9 +/- 3.5 kg/m(2)] with indications for clinical islet transplantation at the University of Alberta were screened for autoimmune disease by history and measurement of anti-transglutaminase antibodies (positive > 10 U/ml), 09.00 h cortisol (followed by adrenocorticotrophic hormone-stimulation if < 495 nmol/l) and thyroid-stimulating hormone to determine the prevalence of coeliac disease, Addison's disease and autoimmune thyroid disease, respectively. RESULTS: Forty per cent of subjects had one or more coexisting autoimmune disease. The prevalence of autoimmune disease was 35%, coeliac disease 8% and Addison's disease 1.6%. In 11 individuals (9%), one or more autoimmune disease were newly detected (seven coeliac disease and five thyroid disease). Seven of 10 cases of coeliac disease were newly detected. A gluten-free diet in individuals with newly diagnosed coeliac disease reduced gastrointestinal symptoms, but indications for clinical islet cell transplantation persisted. CONCLUSIONS: Coexisting autoimmune disease is common in candidates for clinical islet cell transplantation. Screening in this group identified a substantial number of previously unrecognized cases. Clinicians should consider the presence of autoimmune disease even in the absence of classical symptoms. 相似文献
6.
Treatment of rectal cancer by low anterior resection with coloanal anastomosis. 总被引:20,自引:0,他引:20
下载免费PDF全文
![点击此处可从《Annals of surgery》网站下载免费的PDF全文](/ch/ext_images/free.gif)
OBJECTIVE: Our institution's experience with low anterior resection in combination with coloanal anastomosis (LAR/CAA) for primary rectal cancer was reviewed (1) to determine cancer treatment results, 2) to identify risk factors for pelvic recurrence, and 3) to assess the long-term success of sphincter preservation. SUMMARY BACKGROUND DATA: Use of sphincter-preserving resection for mid-rectal and selected distal-rectal cancers continues to increase. As surgical techniques and adjuvant therapy evolve, treatment results must be carefully assessed. METHODS: One hundred thirty-four patients treated for primary rectal cancer by LAR/CAA between 1977 and 1990 were studied retrospectively. All pathologic slides were reviewed. Median follow-up was 4 years. RESULTS: Actuarial 5-year survival for all patients was 73%. Among 36 patients who relapsed, distant metastatic disease had developed at the time of first clinical relapse in most (86%). Pelvic recurrence was detected in 13 patients, an actuarial rate of 11% at 5 years. Mesenteric implants, positive microscopic resection margin, T3 tumor, perineural invasion, blood vessel invasion, and high tumor grade were associated with increased risk for pelvic recurrence. Eleven patients ultimately required permanent colostomy, and in eight instances the cause was pelvic recurrence. CONCLUSIONS: Low anterior resection combined with coloanal anastomosis provides good treatment for mid-rectal cancers and for some distal rectal cancers. Pelvic recurrence is not associated with short distal resection margins but is correlated with the presence of histopathologic markers of aggressive disease in the primary tumor. Long-term preservation of anal sphincter function depends primarily on control of pelvic tumor and can be achieved in more than 90% of patients. 相似文献
7.
Variants of B cell lymphoma 6 (BCL6) and marked atopy 总被引:3,自引:0,他引:3
Chaker N Adra PS Gao XQ Mao Beverly W Baron S. Pauker T. Miki T. Shirakawa JM Hopkin 《Clinical genetics》1998,54(4):362-364
8.
One multiple sclerosis (MS) is diagnosed, important considerations often include life expectancy and the availability of life insurance. We designed a study specifically to examine life expectancy among MS clinic patients and analyzed the data using standard actuarial methods, both including and excluding suicides. The data show that severe MS disability, as measured by an Expanded Disability Status Score (EDSS) of greater than or equal to 7.5, is a major risk factor for death with case fatality ratios for this group of patients approaching 4 times the rate for controls. Conversely, excluding deaths by suicide, case fatality ratios for those with mild and moderate disability (EDSS less than or equal to 7.0) approach 1.4 times and 1.6 times for age- and sex-matched comparison groups. Life tables indicate that the overall life expectancy for MS is only about 6 to 7 years less than that for the "insured" population without MS. 相似文献
9.
Clustering patterns of LOD scores for asthma-related phenotypes revealed by a genome-wide screen in 295 French EGEA families 总被引:3,自引:0,他引:3
Bouzigon E Dizier MH Krähenbühl C Lemainque A Annesi-Maesano I Betard C Bousquet J Charpin D Gormand F Guilloud-Bataille M Just J Le Moual N Maccario J Matran R Neukirch F Oryszczyn MP Paty E Pin I Rosenberg-Bourgin M Vervloet D Kauffmann F Lathrop M Demenais F 《Human molecular genetics》2004,13(24):3103-3113
A genome-wide scan for asthma phenotypes was conducted in the whole sample of 295 EGEA families selected through at least one asthmatic subject. In addition to asthma, seven phenotypes involved in the main asthma physiopathological pathways were considered: SPT (positive skin prick test response to at least one of 11 allergens), SPTQ score being the number of positive skin test responses to 11 allergens, Phadiatop (positive specific IgE response to a mixture of allergens), total IgE levels, eosinophils, bronchial responsiveness (BR) to methacholine challenge and %predicted FEV(1). Four regions showed evidence for linkage (P=0.001): 6q14 for %FEV(1), 12p13 for IgE, 17q22-q24 for SPT and 21q21 for both SPTQ and %FEV(1). Nine other regions indicated smaller linkage signals (0.001
相似文献
10.
Sarangi G Chayani N Mahapatra A Mahapatra D Paty BP Parida B 《Indian journal of pathology & microbiology》2004,47(4):553-555
Rhodococcus equi (R. equi) primarily causes zoonotic infections affecting grazing animals and is an unusual cause of infection in immunocompetent human beings. We report a case of bacteremia due to R. equi a rare isolate in a child suffering from protein energy malnutrition 相似文献