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The coronavirus disease 2019 (COVID-19) is associated with high morbidity and mortality, prompting overwhelmed hospital systems to reallocate resources to those stricken with the disease. In response, many liver transplantation programs unexpectedly came to an abrupt halt, significantly affecting the lives of living donors and recipients around the world. As the risk-benefit scale of liver transplantation has changed in the era of COVID-19, it is prudent to understand the impact of COVID-19 on those with underlying liver disease and those in need of a liver transplant. In this review, we discuss recommendations put forth by hepatology and transplant societies, summarize results from emerging studies, and propose strategies to appropriately risk stratify patients prior to transplantation. 相似文献
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Background and Purpose
Stroke is one of the most common neurological manifestations of infective endocarditis. The use of intravenous tissue plasminogen activator (t-PA) in the management of acute ischemic stroke is the accepted standard of practice. Current guidelines for intravenous (IV) t-PA therapy in acute ischemic stroke do not exclude patients with infective endocarditis. 相似文献5.
BACKGROUND: Although current recommendations advocate screening persons 50 years of age or older for colorectal cancer (CRC), actual screening practice is highly variable among primary care physicians (PCPs). Knowledge of the factors that influence whether or not screening is offered during a clinic visit is essential to develop effective screening strategies. METHODS: A cross-sectional telephone survey of one in four randomly selected patients aged 50 years or older (n = 400) attending a primary care clinic within an integrated health care system in central Texas was conducted. A survey of all PCPs (n = 32) at the practice sites was also administered. RESULTS: The visit type was an important determinant of whether CRC screening was discussed, with most discussion occurring during visits for physicals (P < 0.0001). This finding was corroborated by the physician survey. Patient age and education were also associated with a higher likelihood of having been offered CRC screening (P = 0.009 and 0.014, respectively). Patient race, gender, primary language, PCP, or clinics attended were not significantly associated with the discussion of CRC screening. CONCLUSIONS: Discussions regarding CRC screening are most likely to occur during preventive care visits. Thus, facilitating preventive visits especially for the elderly represents an opportunity to improve CRC screening rates in primary care practice. 相似文献
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Ugo Giovanni Falagario Anna Lantz Ivan Jambor Alberto Martini Parita Ratnani Vinayak Wagaskar Patrick‐Julien Treacy Alessandro Veccia Carlo Andrea Bravi Hafis O Bashorun Deron Phillip Sara Lewis Kenneth Haines Luigi Cormio Giuseppe Carrieri Ash Tewari 《International journal of urology》2021,28(1):47-52
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Parita Sanghani Beng Ti Ang Nicolas Kon Kam King Hongliang Ren 《Surgical oncology》2018,27(4):709-714
Glioblastoma multiforme (GBM) are aggressive brain tumors, which lead to poor overall survival (OS) of patients. OS prediction of GBM patients provides useful information for surgical and treatment planning. Radiomics research attempts at predicting disease prognosis, thus providing beneficial information for personalized treatment from a variety of imaging features extracted from multiple MR images. In this study, MR image derived texture features, tumor shape and volumetric features, and patient age were obtained for 163 patients. OS group prediction was performed for both 2-class (short and long) and 3-class (short, medium and long) survival groups. Support vector machine classification based recursive feature elimination method was used to perform feature selection. The performance of the classification model was assessed using 5-fold cross-validation. The 2-class and 3-class OS group prediction accuracy obtained were 98.7% and 88.95% respectively. The shape features used in this work have been evaluated for OS prediction of GBM patients for the first time. The feature selection and prediction scheme implemented in this study yielded high accuracy for both 2-class and 3-class OS group predictions. This study was performed using routinely acquired MR images for GBM patients, thus making the translation of this work into a clinical setup convenient. 相似文献
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Nidom CA Yamada S Nidom RV Rahmawati K Alamudi MY Kholik Indrasari S Hayati RS Iwatsuki Horimoto K Kawaoka Y 《Virus genes》2012,44(3):459-465
Since 2003, highly pathogenic H5N1 avian influenza viruses have caused outbreaks among poultry in Indonesia every year, producing
the highest number of human victims worldwide. However, little is known about the H5N1 influenza viruses that have been circulating
there in recent years. We therefore conducted surveillance studies and isolated eight H5N1 viruses from chickens. Phylogenic
analysis of their hemagglutinin and neuraminidase genes revealed that all eight viruses belonged to clade 2.1.3. However,
on the basis of nucleotide differences, these viruses could be divided into two groups. Other viruses genetically closely
related to these two groups of viruses were all Indonesian isolates, suggesting that these new isolates have been evolving
within Indonesia. Among these viruses, two distinct viruses circulated in the Kalimantan islands during the same season in
2010. Our data reveal the continued evolution of H5N1 viruses in Indonesia. 相似文献
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Philip Gerretsen Julia Kim Parita Shah Lena Quilty Thushanthi Balakumar Fernando Caravaggio Eric Plitman Jun Ku Chung Yusuke Iwata Bruce G. Pollock Satya Dash Sanjeev Sockalingam Ariel Graff-Guerrero 《Primary Care Diabetes》2018,12(4):371-378