全文获取类型
收费全文 | 6501篇 |
免费 | 316篇 |
国内免费 | 34篇 |
专业分类
耳鼻咽喉 | 65篇 |
儿科学 | 594篇 |
妇产科学 | 119篇 |
基础医学 | 703篇 |
口腔科学 | 99篇 |
临床医学 | 389篇 |
内科学 | 1419篇 |
皮肤病学 | 82篇 |
神经病学 | 321篇 |
特种医学 | 118篇 |
外国民族医学 | 1篇 |
外科学 | 1067篇 |
综合类 | 132篇 |
一般理论 | 1篇 |
预防医学 | 358篇 |
眼科学 | 255篇 |
药学 | 680篇 |
中国医学 | 26篇 |
肿瘤学 | 422篇 |
出版年
2023年 | 46篇 |
2022年 | 113篇 |
2021年 | 198篇 |
2020年 | 105篇 |
2019年 | 131篇 |
2018年 | 187篇 |
2017年 | 121篇 |
2016年 | 172篇 |
2015年 | 168篇 |
2014年 | 240篇 |
2013年 | 317篇 |
2012年 | 401篇 |
2011年 | 419篇 |
2010年 | 269篇 |
2009年 | 212篇 |
2008年 | 351篇 |
2007年 | 339篇 |
2006年 | 340篇 |
2005年 | 336篇 |
2004年 | 284篇 |
2003年 | 276篇 |
2002年 | 193篇 |
2001年 | 121篇 |
2000年 | 142篇 |
1999年 | 114篇 |
1998年 | 44篇 |
1997年 | 26篇 |
1995年 | 25篇 |
1994年 | 26篇 |
1993年 | 34篇 |
1992年 | 74篇 |
1991年 | 71篇 |
1990年 | 71篇 |
1989年 | 64篇 |
1988年 | 72篇 |
1987年 | 60篇 |
1986年 | 61篇 |
1985年 | 67篇 |
1984年 | 52篇 |
1983年 | 41篇 |
1980年 | 37篇 |
1979年 | 39篇 |
1978年 | 32篇 |
1977年 | 30篇 |
1975年 | 37篇 |
1974年 | 38篇 |
1973年 | 23篇 |
1972年 | 25篇 |
1971年 | 26篇 |
1970年 | 31篇 |
排序方式: 共有6851条查询结果,搜索用时 15 毫秒
1.
Annals of Surgical Oncology - 相似文献
2.
Pankaj Kumar Mishra 《European journal of cardio-thoracic surgery》2006,29(5):861-2; author reply 862
3.
Palat Balachandran M.S. M.Ch. Shaleen Agarwal M.S. M.Ch. Narendra Krishnani M.D. Chandra M. Pandey Ph.D. Ashok Kumar M.S. M.Ch. Sadiq S. Sikora M.S. Rajan Saxena M.S. Vinay K. Kapoor M.S. 《Journal of gastrointestinal surgery》2006,10(6):848-854
The aim of this study was to examine the predictors of long-term survival (>24 months) in patients with gall bladder cancer.
A retrospective review of 117 cases of gall bladder cancer resected between 1989 and 2000. The resections included 80 simple
cholecystectomies and 37 extended procedures. Patients with survival >24 months (n=44) were compared with those having survival
<24 months (n=73) for 17 prognostic factors. Overall median survival was 16 months with a 5-year survival of 27%. T status
(P=.000) and adjuvant chemoradiotherapy (P=.001) were independent predictors of long-term survival. Survival advantage was
seen in T3N+ve disease (P=.007) with extended procedures. Complete (R0) resection was attained in 30 patients with a 5-year
survival advantage of 30% as compared with incomplete (R1) resection (P=.0002). Adjuvant chemoradiotherapy improved survival
in simple cholecystectomy group (P=.0008) but no advantage was seen after extended procedures. Stage III (P=.001) and node-positive
disease (P=.0005) had significant benefit with adjuvant therapy. Poor differentiation and vascular invasion were associated
with poor long-term survival. R0 resection was associated with prolonged survival. Extended procedures improved survival in
patients with T3N+ve disease. Addition of chemoradiotherapy made significant improvement in long-term survival in stage III
and node-positive lesions and in patients undergoing simple cholecystectomy. R0 resection predicted long-term survival in
gall bladder cancer. T3 N+ve disease had better survival after extended procedures. Adjuvant chemoradiotherapy improved survival
in stage III and node-positive disease. Poor differentiation and vascular invasion were adverse predictors of survival. 相似文献
4.
Pankaj Dabir Snehal Dabir B V Siva Prasad M V R Reddy 《Infection, genetics and evolution》2006,6(4):287-291
Molecular characterization of Wuchereria bancrofti is essential to develop suitable anti-filarial drugs and vaccines. We describe here isolation, sequence analysis and cloning of a partial cDNA of an enzyme superoxide dismutase from this parasite. The immunoscreening of a lambda zap W. bancrofti microfilarial (Mf) cDNA library with microfilaremic sera had resulted in the isolation of several seroreactive clones including, WbSOD. This clone contained a 309 bp insert and showed significant nucleotide and deduced amino acid sequence homologies to the superoxide dismutases of other nematode parasites. The antioxidant property of this enzyme may have important contribution in the defense mechanism of the parasite against host immune response. 相似文献
5.
Pankaj Hari Anand Srivastava Arun Kumar Gupta Rajendra N. Srivastava 《Pediatric nephrology (Berlin, Germany)》1997,11(4):497-498
Acute renal failure (ARF) developed in a 7-week-old infant due to bilateral candidal bezoars (fungal balls) causing obstruction
at the pelviureteric junction. The baby was born at term with an appropriate birthweight, and had been treated with broad-spectrum
antibiotics for respiratory distress and septicemia during the 1st week of life. Recovery from ARF followed renal decompression
with bilateral nephrostomy tube placement and parenteral administration of amphotericin B and 5-flucytosine.
Received August 21, 1996; received in revised form and accepted January 3, 1997 相似文献
6.
7.
Mihaly Arato Ed Frecska Duncan J. MacCrimmon Rick Guscott Bishan Saxena Kornelia Tekes Laszlo Tothfalusi 《Progress in neuro-psychopharmacology & biological psychiatry》1991,15(6):759-764
1. Postmortem neurochemical investigations revealed interhemispheric asymmetry in the mediofrontal region of human brain. Significantly higher right hemisphere serotonin metabolite (5HIAA) content as well as increased maximal imipramine binding (IB) were found in the right hemisphere than in the left side.
2. IB did not show a gender difference in the mediofrontal area. However, women had higher IB in the right orbital frontal cortex than did men.
3. In vivo pharmaco-EEG results tend to support the postmortem neurochemical data. Intravenous chlorimipramine resulted in an asymmetric topographic distribution of the P300 auditory evoked potential, peak amplitudes were shifted to the right hemisphere. 相似文献
8.
K Taori R Sanyal J Rathod S Mahajan G Jajoo V Saxena M Bhagat 《Journal of Medical Imaging and Radiation Oncology》2006,50(4):298-305
Hydatid disease has characteristic imaging features on CT, which allow accurate preoperative diagnosis in most cases. However, when it occurs at unusual locations the diagnosis is often difficult, especially as the imaging appearance varies at different sites. In this article we have presented a pictorial review of the CT features of disease due to Echinococcus granulosus at various sites in the human body. 相似文献
9.
Ian F. Dunn Pankaj K. Agarwalla Alexander M. Papanastassiou William E. Butler Edward R. Smith 《Child's nervous system》2007,23(10):1191-1194
Objective Approximately 10% of patients with neurofibromatosis I (NFI) patients will have central nervous system (CNS) tumors. The most
common of these are hypothalamic–optic gliomas, followed by brainstem and cerebellar pilocytic astrocytomas. While isolated
pilocytic astrocytomas in NFI are well described, the appearance of multiple pilocytic astrocytomas in an individual patient
is less common. The most frequent combination in NFI patients with more than one pilocytic astrocytoma is optic tract/hypothalamic
and brainstem. Other combinations are exceedingly rare; multiple pilocytic astrocytomas have only been reported once in the
cerebral hemispheres in a patient with NFI. This report presents the first documented case, to our knowledge, of multiple
pilocytic astrocytomas in the cerebellum of a patient with NF1.
Methods Case report.
Conclusion The finding of multiple cerebellar pilocytic astrocytomas in a patient with NF1 is important because it expands the spectrum
of presentations for patients with NF1 and also highlights specific diagnostic and therapeutic challenges faced by the treating
physicians. The genetic and molecular basis of NF1 is reviewed. Strategies of diagnosis and treatment outlined here are relevant
to both patients with NF1 and all patients with multiple posterior fossa tumors. 相似文献
10.
The optimal conditions for inactivation of Bordetella pertussis organisms with glutaraldehyde for the production of a safe and potent whole cell pertussis vaccine were investigated. Two bacterial harvests from B. pertussis strain 10536 were treated with glutaraldehyde, each with 0.025, 0.05 and 0.1% concentrations of glutaraldehyde for 10, 60 and 120 min. The nine types of glutaraldehyde-inactivated pertussis vaccine (GIPV) and conventional heat-inactivated pertussis vaccine (HIPV) preparations made from two bacterial harvests were comparatively evaluated for the mouse weight gain test (MWGT), potency, and the histamine-sensitization (HS) and leucocytosis-promoting-factor (LPF) tests. The minimum period for killing the B. pertussis organisms with glutaraldehyde was>10 min for 0.025%, 10 min for 0.05% and 5 min for 0.1% concentration. The average loss in opacity varied from 5 to 10% for GIPV preparations and was 14% for HIPV preparations. The GIPV preparations except those inactivated with 0.025% glutaraldehyde for 10 min (GIPV-A) were much less toxic than the HIPV preparations in the MWGT. The GIPV-A preparations did not pass the MWGT. The GIPV preparations were also much less toxic in HS and LPF tests than the HIPV preparation. The potency of GIPV preparations inactivated with 0.05% glutaraldehyde for 10 min (GIPV-D) was similar to that of HIPV preparations. The prolonged treatments with glutaraldehyde reduced the potency. The GIPV-D preparation with good potency and less toxicity was found to be inactivated with glutaraldehyde under optimal conditions. All the preparations were innocuous in the abnormal toxicity test. 相似文献