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Dalirsani Zohreh Ghazi Narges Delavarian Zahra Pakfetrat Atessa Esmaily Habibollah Davaji Mina Alavi Hossein Salari Sedigh Hamideh Shafieian Reyhaneh 《Lasers in medical science》2021,36(7):1527-1534
Lasers in Medical Science - Diabetes mellitus is mostly interrelated to deficiency in wound healing. Low-level laser therapy has been shown to exert reliable effects on the acceleration of wound... 相似文献
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Zeinab Karimi Zahra Pakfetrat Jamshid Roozbeh Sahar Janfeshan 《Clinical and experimental pharmacology & physiology》2020,47(9):1584-1590
Gentamicin is an aminoglycoside antibiotic commonly administrated to patients with Gram-negative infections. Gentamicin induced nephrotoxicity by functional and structural impairment. Toll-like receptors (TLRs) as key mediators in the innate and adaptive immune system response involved in gentamicin-induced nephrotoxicity. The present study aimed to investigate the gene expression of TLR2 and pro-inflammatory cytokines in the renal tissues and buffy coat of the whole blood in gentamicin-treated rats. Twenty adult male Sprague Dawley rats weighing 180–200 were randomly divided into gentamicin (100 mg/kg, i.p) and control groups (n = 10). After 10 days, the serum creatinine (Cr) levels and blood urea nitrogen (BUN) were measured. The mRNA levels of TLR2, tumour necrosis factor (TNF)-α, interleukin (IL)-1β, and monocyte chemoattractant peptide (MCP)-1 were investigated in the renal tissue and buffy coat by qRT-PCR. Kidney histological analysis performed by hematoxylin-eosin (H&E) staining. Functional disturbance is characterized by a significant increase in the serum levels of Cr and BUN in the gentamicin group. Renal tissue slides of the gentamicin group indicated severe glomerular and tubular damage including lobulation of the glomerular tuft, Bowman's space enlargement, acute tubular necrosis, and proximal tubular destruction. The mRNA levels of IL-1β, TNF-α, MCP-1, and TLR2 increased in the buffy coat, but all of them except TLR2 decreased in the renal tissues in the gentamicin group compared with controls. Gentamicin administration induced relative systemic inflammation, which may be related to an increase in the mRNA levels of TLR2 results in gene expression of pro-inflammatory chemokines and cytokines including IL-1β, TNF-α, and MCP-1 in immune cells. 相似文献
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Maryam Pakfetrat Mohammad Hossein Nikoo Leila Malekmakan Mahmood Tabandeh Jamshid Roozbeh Mahshid Hashemi Nasab Mohammad Ali Ostovan Soheila Salari Mohammad Kafi Najmeh Moin Vaziri Farzad Adl Mehdi Hosseini Parviz Khajehdehi 《International urology and nephrology》2009,41(3):629-634
Background Contrast-induced nephropathy (CIN) is commonly encountered. Because the therapy of choice for prevention of CIN is controversial,
in this study we compared the preventive efficacy of bicarbonate (Bi) infusion in dextrose water versus normal saline (NLS)
infusion alone or in combination with oral acetazolamide (AZ).
Methods In a double-blind and randomized clinical trial, all patients undergoing coronary angiography or percutaneous coronary intervention
received NLS (NLS group), its combination with AZ (AZ group) or infusion of Bi (Bi group) before the procedures. RIFLE (risk
of renal failure, injury to the kidney, failure of kidney function, loss of kidney function, and end-stage renal disease)
criteria were used to define CIN-associated acute kidney injury (AKI).
Results The risk of AKI in CIN was significantly lower in the Bi and AZ groups than in the NLS group (P ≤ 0.04). Comparing pre-treatment and post-treatment values in each group the following results were obtained: serum creatinine
(Scr) increased and eGFR decreased significantly in the NLS group (P = 0.04) and in all patients (P = 0.001, P = 0.02, respectively). In addition, serum potassium decreased significantly in the Bi and NLS groups (P ≤ 0.02). Also, serum Bi increased significantly in the Bi group (P = 0.001) whereas it decreased significantly in the AZ group (P = 0.001). Urinary pH also increased in all groups (P ≤ 0.04) except the NLS group (P > 0.05).
Conclusions It seems that both Bi and AZ reduce the risk of CIN-related AKI, and close monitoring of serum potassium is needed during
bicarbonate infusion. 相似文献
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The preventive effect of pentoxifylline on contrast-induced nephropathy: a randomized clinical trial
Vahideh Yavari Mohammad Ali Ostovan Javad Kojuri Raha Afshariani Alireza Hamidian Jamshid Roozbeh Maryam Pakfetrat 《International urology and nephrology》2014,46(1):41-46
Background
Percutaneous coronary intervention provides a high-risk condition for incidence of CIN even in patients with normal renal function. Pentoxifylline (PTX) with a variety of mechanisms may prevent CIN.Materials and methods
Between April 5, 2011, and February 20, 2012, all consecutive eligible patients referred for elective percutaneous coronary intervention were asked to participate in the study (n = 199). Eligibility was defined as the age between 18 and 65 years and baseline serum creatinine ≤132.6 μmol/l (1.5 mg/dl). The patients were randomly allocated to two groups either receiving saline or saline plus pentoxifylline 400 mg orally three times a day for 48 h. Serum creatinine was measured 24 h prior to the procedure and 48 h thereafter. The primary endpoint was occurrence of CIN defined as 25 % rise in serum creatinine 48 h after the procedure.Results
The overall incidence of CIN was 6 % in this study (6.2 % in the PTX group versus 5.9 % in the hydration group, P = 0.92). Absolute rise in serum creatinine was not also significantly different between the two groups (P = 0.97). In hypertensive patients, however, the incidence of CIN was lower among those receiving PTX: 5 % in the PTX group versus 8.7 % in the hydration group. Nevertheless, this difference was not statistically significant (P = 0.68).Conclusion
Short-term prophylaxis with pentoxifylline added to optimal hydration does not seem to reduce the risk of CIN in patients with normal renal function undergoing PCI. Further clinical trials in patients with renal impairment are warranted to define its role. 相似文献8.
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Arjmandi K Yaghobi R Ravanshad M Hosseini SY Roozbeh J Pakfetrat M 《Transplantation proceedings》2011,43(2):554-556