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排序方式: 共有271条查询结果,搜索用时 15 毫秒
1.
Summary A review is made of the current management strategies of abscesses in basal ganglia and thalamus, based on a review of the literature and three of our own cases. Clinical picture, aetiology, diagnostic, surgical treatment and outcome are discussed. Stereotactic abscess puncture in combination with temporary drainage and rinsing of the abscess cavity in combination with systemic medication of antibiotics has become the management of choice with satisfactory results. 相似文献
2.
Beat Morell Manuel Meyer Othmar Porr Ulrich Bay Ernst R. Froesch 《Acta diabetologica》1984,21(4):303-313
Summary The objective of this study was to follow the development of microalbuminuria and nerve conduction velocity under continuous
i.v. insulin therapy over a limited period of 4 months. For this purpose, 8 labile type I diabetics were selected (age 33±8
years, duration of diabetes 16±9 years) and treated conventionally with two insulin injections daily over 4 months. Afterwards,
the same patients were treated with continuous i.v. insulin infusion and finally again with two injections daily over 4 months
each. This procedure allowed each diabetic to serve as his own control. HbA1, microalbuminuria, nerve conduction velocity and relative refractory period of the ulnar nerve were checked at montly intervals.
During the continuous i.v. infusion over 4 months, blood sugar values were significantly lower, glucosuria had disappeared
almost completely and the glycosylated hemoglobin had fallen to near normal values. The mean rate of albumin excretion was
16±5 μg/min at rest and 76±26 μg/min during exercise (normal: 3.9±0.4 and 4.8±1.2 μg/min, respectively) and did not change
significantly. Nerve conduction velocity in the ulnar nerve rose significantly under i.v. insulin therapy from 47.9±0.6 m/sec
to 52±0.6 m/sec. Similarly, the relative refractory period of the same nerve fell significantly from 3.7±0.2 to 1.9±0.1 msec
(i.e. to within normal range). It is concluded that functional disturbances of peripheral nerve can regress by improved blood
sugar control with continuous i.v. insulin infusion over 4 months. On the other hand, incipient microangiopathy measured as
microalbuminuria remains unchanged over the same period of time. If an improvement is at all possible, considerably longer
periods of euglycemia are likely to be necessary.
Supported by Grant No. 3.964-0.80 from the Swiss National Science Foundation. 相似文献
3.
4.
Berger M Cunningham-Rundles C Bonilla FA Melamed I Bichler J Zenker O Ballow M 《Journal of clinical immunology》2007,27(5):503-509
Subjects with primary immune deficiency diseases treated with intravenous immunoglobulin (n=42) received intravenous infusions of Carimune NF Liquid every 3–4 weeks for 6 months without routine premedication. The
mean dose/patient/infusion was 278.5–800.7 mg/kg. Also, 80.4% of infusions achieved maximum rates of ≥3.5 mg/kg/min; 32% of
infusions were associated with adverse events during or within 48 h of their end (upper 95% confidence interval was 39.4%,
meeting the Food and Drug Administration (FDA) criterion for acceptable tolerability), and 54.8% of subjects had at least
one temporally associated adverse event considered at least possibly drug-related (headache: 35.7% of subjects, 12.4% of infusions;
nausea: 14.3%, 3.5%; myalgia: 14.3%, 3.2%; fatigue: 11.9%, 5.7%). The frequencies of these were highest after the first infusion.
There were no serious drug-related adverse events or acute serious bacterial infections. Serum IgG trough levels were unchanged
from baseline. Carimune NF Liquid, a ready-to-use, high-concentration, liquid immunoglobulin preparation is safe and effective.
On behalf of the study group 相似文献
5.
Max L. Eckstein PhD Othmar Moser PhD Norbert J. Tripolt PhD Peter N. Pferschy MSc Anna A. M. Obermayer MD Harald Kojzar BSc Alexander Mueller MSc Farah Abbas BSc Caren Sourij MD Harald Sourij MD 《Diabetes, obesity & metabolism》2021,23(7):1681-1684
To investigate differences in heart rate variability (HRV) during oral glucose tolerance tests (OGTTs) in response to the rate of change in glucose and to different glycaemic ranges in individuals with type 1 diabetes. This was a single-centre, prospective, secondary outcome analysis in 17 individuals with type 1 diabetes (glycated haemoglobin 53 ± 6.3 mmol/L), who underwent two OGTTs (after 12 and 36 hours of fasting) investigating differences in HRV in response to rapid glucose increases/decreases and different glycaemic ranges during OGTT. Based on the rate of change in glucose level, the variables heart rate (P < 0.001), square root of the mean standard difference of successive R-R intervals (P = 0.002), percentage of pairs of R-R intervals with >50 ms difference (P < 0.001) and corrected QT interval (P = 0.04) were significantly altered, with HRV particularly reduced during episodes of rapid glucose rises. Glycaemic ranges during OGTT had no impact on HRV (P < 0.05). Individuals with type 1 diabetes showed no changes in HRV in response to different glycaemic ranges. HRV was dependent on the rate of change in glucose, especially rapid increases in glucose level. 相似文献
6.
D. Grabs M. Bergmann M. Urban A. Post M. Gratzl 《The European journal of neuroscience》1996,8(1):162-168
GTP-binding rab proteins, present in synaptic vesicles and endocrine secretory granules, have been shown to be involved in the control of regulated exocytosis. We found rab3 proteins in immunoblots of diverse areas of the mouse central nervous system (spinal cord, olfactory bulb, hippocampus, cerebellum and neocortex). Immunohistochemical observations at light- and electron-microscopical levels in the hippocampus and other areas revealed rab3 proteins in virtually all synaptic fields and terminals of the areas investigated. In the retina, rab3A immunoreactivity was confined to the inner and outer plexiform layers. Ultrastructural examination revealed that rab3A was present in conventional terminals in the inner plexiform layer and in horizontal cell processes of the outer plexiform layer. In contrast ribbon synapses, which play a key role in transferring information from the photoreceptor cells to the central nervous system, were immunonegative. We also tested whether other proteins of the rab3 family are present in ribbon synapses. However, using an antibody recognizing rab3B and rab3C in addition to rab3A, we found no immunoreactivity in these synapses. Interestingly, we observed also no immunoreactivity for synaptosomal-associated protein 25 (SNAP-25) in ribbon synapses, but conventional synapses and horizontal cell processes were heavily stained. Our data show that the known rab3 and SNAP-25 isoforms, which are components of the secretory apparatus of conventional synapses, are absent from ribbon synapses of the retina. Our observations suggest different mechanisms of transmitter exocytosis in conventional and ribbon terminals. 相似文献
7.
Nikolai E. Lazarov Sebastian Reindl Florian Fischer Manfred Gratzl 《Respiratory physiology & neurobiology》2009,165(2-3):131-136
Carotid body (CB) chemoreceptors are the main sensors detecting systemic hypoxia. Studies in animals revealed that dopamine and histamine may serve as transmitters between the chemoreceptor cells and the afferent nerve. To gain insight whether histamine and dopamine could play a role in the human CB and thus be important for the understanding of breathing disorders, we have investigated the chemosensory traits in human CBs from nine subjects of different ages obtained at autopsy. Immunohistochemistry revealed expression of histidine decarboxylase, vesicular monoamine transporter 2, histamine receptors 1 and 3 in virtually all chemosensory cells within the glomeruli of different ages. By contrast, catecholaminergic traits (tyrosine hydroxylase and vesicular monoamine transporter 1) were only detected in a subset of CB chemosensory cells at each age group while dopamine D2 receptors were expressed in the great majority of them. Our data suggest that histamine along with catecholamines may serve as transmitters between chemoreceptor cells and the afferent nerve in humans as well. 相似文献
8.
Franziska Carmen Grafen Valentin Neuhaus Othmar Schöb Matthias Turina 《Langenbeck's archives of surgery / Deutsche Gesellschaft fur Chirurgie》2010,395(1):57-63
Purpose
The aim of this study is to compare the results of laparoscopic management of acute small bowel obstruction (SBO) from abdominal adhesions to both exploratory laparotomy and secondary conversion to open surgery. 相似文献9.
10.
Skin tuberculosis with atypical mycobacteria 8 years after combined pancreas-kidney transplantation 总被引:1,自引:0,他引:1
Schmekal B Janko O Zazgornik J Schinko H Bogner S Syre G Biesenbach G 《American journal of nephrology》2002,22(5-6):566-568
We report on a Mycobacterium marinum infection in a diabetic woman 8 years after undergoing a combined pancreas-kidney transplantation. This is, to our knowledge, the first case report on an isolated skin infection with atypical mycobacteria after simultaneous pancreas-kidney transplantation. A genetic probe categorization revealed an infection with M. marinum. Skin tuberculosis caused by M. marinum is an uncommon complication in kidney or pancreas-kidney transplant recipients, hence the diagnosis can be delayed. 相似文献