全文获取类型
收费全文 | 527篇 |
免费 | 22篇 |
国内免费 | 7篇 |
专业分类
儿科学 | 55篇 |
妇产科学 | 4篇 |
基础医学 | 30篇 |
口腔科学 | 8篇 |
临床医学 | 63篇 |
内科学 | 103篇 |
皮肤病学 | 5篇 |
神经病学 | 16篇 |
特种医学 | 153篇 |
外科学 | 63篇 |
综合类 | 6篇 |
预防医学 | 20篇 |
眼科学 | 3篇 |
药学 | 15篇 |
肿瘤学 | 12篇 |
出版年
2021年 | 3篇 |
2020年 | 7篇 |
2019年 | 3篇 |
2018年 | 6篇 |
2017年 | 5篇 |
2016年 | 4篇 |
2015年 | 8篇 |
2014年 | 6篇 |
2013年 | 12篇 |
2012年 | 15篇 |
2011年 | 12篇 |
2010年 | 29篇 |
2009年 | 9篇 |
2008年 | 7篇 |
2007年 | 16篇 |
2006年 | 16篇 |
2005年 | 9篇 |
2004年 | 12篇 |
2003年 | 8篇 |
2002年 | 6篇 |
2001年 | 8篇 |
2000年 | 4篇 |
1999年 | 8篇 |
1998年 | 31篇 |
1997年 | 24篇 |
1996年 | 27篇 |
1995年 | 26篇 |
1994年 | 16篇 |
1993年 | 19篇 |
1992年 | 3篇 |
1991年 | 4篇 |
1990年 | 8篇 |
1989年 | 15篇 |
1988年 | 17篇 |
1987年 | 13篇 |
1986年 | 12篇 |
1985年 | 20篇 |
1984年 | 11篇 |
1983年 | 13篇 |
1982年 | 22篇 |
1981年 | 9篇 |
1980年 | 14篇 |
1979年 | 1篇 |
1978年 | 5篇 |
1977年 | 12篇 |
1976年 | 12篇 |
1975年 | 5篇 |
1974年 | 1篇 |
1970年 | 1篇 |
1968年 | 1篇 |
排序方式: 共有556条查询结果,搜索用时 15 毫秒
1.
B Gerdts AFPM Vloemans RW Kreis 《Journal of the European Academy of Dermatology and Venereology》2007,21(6):781-788
BACKGROUND: Toxic epidermal necrolysis (TEN) is a severe and potentially fatal drug reaction characterized by an extensive skin rash with blisters and exfoliation, frequently accompanied by mucositis. The wounds caused by TEN are similar to second-degree burns and severe cases may involve large areas of skin loss. OBJECTIVES: Analysis of our results in patients with TEN and evaluation of the variety of therapeutic interventions that has been studied and suggested in TEN. PATIENTS/METHODS: Retrospective analysis of 19 consecutive patients with TEN treated in our burns centre between 1989 and 2004. RESULTS: Immediate withdrawal of any potentially fatal drug, maximum supportive care, and a restricted and tailored antibiotic, medical and surgical treatment regimen confined mortality to 21%, whereas prognosis scores like APACHE II and SCORTEN predicted mortality of 22 and 30%, respectively. A positive contribution of selective digestive decontamination is suggested but has yet to be established. CONCLUSIONS: Because of a potentially fatal outcome, fast referral of a patient suspected of TEN to a specialized centre (mostly a burns unit or specialized dermatology centre) for expert wound management and tailored comprehensive care is strongly advised and contributes to survival. 相似文献
2.
1背景 育龄妇女常见慢性下腹痛,可造成身体损害、情绪忧伤及导致巨大的健康服务费用。美国在这方面的花费超过8亿8千万美元(Mathias 1996)。英国全国数据库的一般性诊治资料显示,慢性下腹痛发病率及流行率与偏头痛、背部痛、哮喘发病率相似(Zondervan 1999)。 相似文献
3.
N. M. van Schoor D. L. Knol C. A. W. Glas R. W. J. G. Ostelo A. Leplège C. Cooper O. Johnell P. Lips 《Osteoporosis international》2006,17(4):543-551
Introduction Vertebral deformities are a common consequence of osteoporosis and are known to decrease quality of life. The Qualeffo–41
is a quality-of-life questionnaire especially developed for measuring quality of life in patients with vertebral deformities.
It consists of 41 questions arranged in five domains: pain, physical function, social function, general health perception,
and mental function. The objectives of this study were: (1) to develop a shorter version of the Qualeffo–41 by removing redundant
questions; and (2) to investigate the scale characteristics, reliability, and validity of this shorter version.
Methods The study was performed using data from the Qualeffo validation study and the Multiple Outcomes of Raloxifene Evaluation (MORE)
study. The analyses were performed in patients with vertebral deformities (n=579). Factor analysis on polychoric correlations and an item response theory (IRT) model, i.e., the generalized partial credit
model (GPCM), were used to create a shorter version of Qualeffo–41. Using GPCM, scoring weights were computed for all items.
Results Three items were removed from the data set because of too many missing values. Factor analysis identified three instead of
five domains: (1) pain, (2) physical function, and (3) mental function. Five items had factor loadings <0.4 and were not included
in the GPCM. After excluding several items, the domains pain (four items), physical function (18 items), and mental function
(nine items) showed a good, reasonable, and excellent fit, respectively. This indicates that the mental function domain and
the pain domain are more unidimensional than the physical function domain. All three domains showed a very high correlation
(r ≥0.95) with the corresponding domains of the Qualeffo–41.
Conclusions Qualeffo–31 was developed, consisting of three domains with a reasonable to excellent fit to the GPCM. Although the fit to
the GPCM supports the construct validity of the Qualeffo–31, validation in a new study should be performed before using it
in practice. 相似文献
4.
5.
6.
7.
8.
9.
10.
Dou Q; Tarnuzzer RW; Williams RS; Schultz GS; Chegini N 《Molecular human reproduction》1997,3(11):1005-1014