全文获取类型
收费全文 | 54篇 |
免费 | 3篇 |
专业分类
儿科学 | 1篇 |
基础医学 | 4篇 |
口腔科学 | 3篇 |
临床医学 | 8篇 |
内科学 | 14篇 |
神经病学 | 3篇 |
特种医学 | 2篇 |
外科学 | 6篇 |
综合类 | 5篇 |
预防医学 | 6篇 |
药学 | 1篇 |
中国医学 | 3篇 |
肿瘤学 | 1篇 |
出版年
2023年 | 1篇 |
2022年 | 2篇 |
2021年 | 2篇 |
2020年 | 5篇 |
2019年 | 2篇 |
2018年 | 1篇 |
2016年 | 1篇 |
2015年 | 1篇 |
2014年 | 4篇 |
2013年 | 4篇 |
2012年 | 6篇 |
2011年 | 5篇 |
2010年 | 6篇 |
2009年 | 1篇 |
2008年 | 3篇 |
2007年 | 2篇 |
2006年 | 1篇 |
2005年 | 2篇 |
2003年 | 1篇 |
2001年 | 2篇 |
2000年 | 1篇 |
1999年 | 1篇 |
1996年 | 2篇 |
1993年 | 1篇 |
排序方式: 共有57条查询结果,搜索用时 15 毫秒
1.
2.
3.
Mary van Andel Scott Zaari Phiri Bernard Andrew McFadden Ian Dacre Paul Bingham Cord Heuer Barbara Binney Kelly Buckle Ronel Abila Htun Htun Win Khin Ohnmar Lwin M. Carolyn Gates 《Transboundary and Emerging Diseases》2020,67(1):108-120
Knowledge of the distribution of foot‐and‐mouth disease (FMD) is required if control programmes are to be successful. However, data on the seroprevalence and incidence of affected villages in developing countries with endemic disease are scarce. This is partly due to resource constraints as well as the logistical challenges of conducting intensive surveys and diagnostic testing in remote locations. In this study, we evaluated the performance of low resolution national‐scale data against high resolution local survey data to predict the FMD serological status of 168 villages in the Mandalay and Sagaing Regions of central Myanmar using both logistic regression and random forest modelling approaches. Blood samples for ELISA testing were collected from approximately 30 cattle per village in both the 6 to 18 month age range and in the over 18 month age range to distinguish between recent and historical exposure, respectively. The results of the animal level tests were aggregated to the village level to provide the outcome of interest (village positive or not positive for FMD), and three explanatory data sets were constructed: using only nationally available data, using only data collected by survey and using the combined survey and nationally available data. The true seroprevalence of FMD at the village level was 61% when only young animals were included, but increased to 87% when all animals were included. The best performing model was a logistic regression model using the combined national and survey data to predict recent infection in villages. However, this still incorrectly classified 40% of villages, which suggests that using national‐level data were not reliable enough for extrapolating seroprevalence in regions where conducting detailed surveys is impractical. Other methods for collected data on FMD such as the use of local reporting should be explored. 相似文献
4.
Hong Ng C Norman TR Naing KO Schweitzer I Kong Wai Ho B Fan A Klimidis S 《International clinical psychopharmacology》2006,21(2):87-92
This prospective 6-week study examined the differences in dosage and steady state plasma concentrations of sertraline in Chinese versus Caucasian depressed patients. Two groups of Chinese patients from different geographical sites and a group of Caucasian patients were evaluated with clinical measures during an initial dose of 50 mg/day, with subsequent doses adjusted clinically. The results of 17 Australian Chinese (ACHI), 13 Malaysian Chinese (MCHI) and 15 Australian Caucasians (AC) were analysed. Despite controlling for weight, the AC subjects received a significantly higher dose than both the ACHI (P = 0.002) and the MCHI groups (P = 0.012). However, the mean sertraline concentration to dose ratios at weeks 1 and 6 were not significantly different between the three groups. Sertraline was effective and well tolerated in both ethnic groups with few adverse events. Although there was a lack of difference between groups in the pharmacokinetic results, Chinese depressed patients appeared to require lower dosages with consequently lower plasma concentrations of sertraline compared to Caucasian patients to achieve clinical efficacy. Further studies of the dosages, kinetics and adverse effects of selective serotonin reuptake inhibitors linked with genotyping are necessary. 相似文献
5.
From HER2/Neu signal cascade to androgen receptor and its coactivators: A novel pathway by induction of androgen target genes through MAP kinase in prostate cancer cells 总被引:25,自引:0,他引:25
下载免费PDF全文
![点击此处可从《Proceedings of the National Academy of Sciences of the United States of America》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Shuyuan Yeh Hui-Kuan Lin Hong-Yo Kang Tin Htwe Thin Ming-Fong Lin Chawnshang Chang 《Proceedings of the National Academy of Sciences of the United States of America》1999,96(10):5458-5463
Overexpression of the HER2/Neu protooncogene has been linked to the progression of breast cancer. Here we demonstrate that the growth of prostate cancer LNCaP cells can also be increased by the stable transfection of HER2/Neu. Using AG879, a HER2/Neu inhibitor, and PD98059, a MAP kinase inhibitor, as well as MAP kinase phosphatase-1 (MPK-1), in the transfection assay, we found that HER2/Neu could induce prostate-specific antigen (PSA), a marker for the progression of prostate cancer, through the MAP kinase pathway at a low androgen level. Reporter assays and mammalian two-hybrid assays further suggest this HER2/Neu-induced androgen receptor (AR) transactivation may function through the promotion of interaction between AR and AR coactivators, such as ARA70. Furthermore, we found this HER2/Neu --> MAP kinase --> AR-ARAs --> PSA pathway could not be blocked completely by hydroxyflutamide, an antiandrogen used in the treatment of prostate cancer. Together, these data provide a novel pathway from HER2/Neu to AR transactivation, and they may represent one of the reasons for the PSA re-elevation and hormone resistance during androgen ablation therapy in prostate cancer patients. 相似文献
6.
Sebastian Peters Sabrina Kuespert Eva Wirkert Rosmarie Heydn Benjamin Jurek Siw Johannesen Ohnmar Hsam Sven Korte Florian Timo Ludwig Lars Mecklenburg Heike Mrowetz Barbara Altendorfer Rodolphe Poupardin Susanne Petri Dietmar R. Thal Andreas Hermann Jochen H. Weishaupt Joachim Weis Inci Sevval Aksoylu Sebastian A. Lewandowski Ludwig Aigner Tim-Henrik Bruun Ulrich Bogdahn 《Neurotherapeutics》2021,18(3):1963
7.
Chakravarty D Santos E Ryder M Knauf JA Liao XH West BL Bollag G Kolesnick R Thin TH Rosen N Zanzonico P Larson SM Refetoff S Ghossein R Fagin JA 《The Journal of clinical investigation》2011,121(12):4700-4711
Advanced human thyroid cancers, particularly those that are refractory to treatment with radioiodine (RAI), have a high prevalence of BRAF (v-raf murine sarcoma viral oncogene homolog B1) mutations. However, the degree to which these cancers are dependent on BRAF expression is still unclear. To address this question, we generated mice expressing one of the most commonly detected BRAF mutations in human papillary thyroid carcinomas (BRAF(V600E)) in thyroid follicular cells in a doxycycline-inducible (dox-inducible) manner. Upon dox induction of BRAF(V600E), the mice developed highly penetrant and poorly differentiated thyroid tumors. Discontinuation of dox extinguished BRAF(V600E) expression and reestablished thyroid follicular architecture and normal thyroid histology. Switching on BRAF(V600E) rapidly induced hypothyroidism and virtually abolished thyroid-specific gene expression and RAI incorporation, all of which were restored to near basal levels upon discontinuation of dox. Treatment of mice with these cancers with small molecule inhibitors of either MEK or mutant BRAF reduced their proliferative index and partially restored thyroid-specific gene expression. Strikingly, treatment with the MAPK pathway inhibitors rendered the tumor cells susceptible to a therapeutic dose of RAI. Our data show that thyroid tumors carrying BRAF(V600E) mutations are exquisitely dependent on the oncoprotein for viability and that genetic or pharmacological inhibition of its expression or activity is associated with tumor regression and restoration of RAI uptake in vivo in mice. These findings have potentially significant clinical ramifications. 相似文献
8.
Aung PP Ohnmar M Hlaing MM Kyaw MT Than AA Thwin T Myini TK 《Malaysian journal of nutrition》2010,16(1):91-100
A cross-sectional survey combined with 24-hour dietary recall and food diary was undertaken to assess the calcium intake of the Myanmar population. The study was conducted from November 2003 to October 2005. A total of 886 subjects of both sexes aged above 2 years from three States and Divisions (Bago, Kayin, and Yangon) of Myanmar were included in the study. The major measures were mean daily calcium intake (mg/day) and major sources of calcium in the diet. Overall mean calcium intake was 197+13mg/day (2-9 years), 421+2mg/day (10-19 years), 399+21 mg/day (20-49 years), and 383+25mg/day (>50 years) for males, while the corresponding values for females were 207+17 mg/day, 366+19 mg/day, 387+16 mg/day, and 327 +19 mg/day. Calcium intake was less than 80% of the recommended dietary allowances (RDA) for Myanmar for ages 2-9 years and 10-29 years in all the study areas, and for the 50 years and above age group in Yangon. Fish paste was found to be the major source of calcium. Milk and milk products contributed very little to total calcium intake, contributing 2.1% for residents in Yangon, 5.1% in Pa-an and none in Bago. Consumption of calcium rich foods, particularly milk and milk products, should be encouraged among the Myanmar people. Towards this end, appropriate nutrition education materials should be developed for promotional purposes. 相似文献
9.
10.
Ernie Chen Ling-shiang Chuang Mamta Giri Nicole Villaverde Nai-yun Hsu Ksenija Sabic Sari Joshowitz Kyle Gettler Shikha Nayar Zhi Chai Isaac L. Alter Colleen C. Chasteau Ujunwa M. Korie Siarhei Dzedzik Tin Htwe Thin Aayushee Jain Arden Moscati Gerardus Bongers Judy H. Cho 《Gastroenterology》2021,160(5):1709-1724