全文获取类型
收费全文 | 563篇 |
免费 | 18篇 |
国内免费 | 5篇 |
专业分类
耳鼻咽喉 | 1篇 |
儿科学 | 21篇 |
妇产科学 | 4篇 |
基础医学 | 46篇 |
口腔科学 | 16篇 |
临床医学 | 108篇 |
内科学 | 71篇 |
皮肤病学 | 13篇 |
神经病学 | 27篇 |
特种医学 | 113篇 |
外科学 | 38篇 |
综合类 | 50篇 |
预防医学 | 27篇 |
眼科学 | 10篇 |
药学 | 23篇 |
1篇 | |
中国医学 | 2篇 |
肿瘤学 | 15篇 |
出版年
2021年 | 4篇 |
2018年 | 3篇 |
2017年 | 3篇 |
2015年 | 31篇 |
2014年 | 43篇 |
2013年 | 23篇 |
2012年 | 13篇 |
2011年 | 26篇 |
2010年 | 20篇 |
2009年 | 24篇 |
2008年 | 19篇 |
2007年 | 26篇 |
2006年 | 28篇 |
2005年 | 13篇 |
2004年 | 12篇 |
2003年 | 11篇 |
2002年 | 10篇 |
2001年 | 8篇 |
2000年 | 6篇 |
1999年 | 11篇 |
1998年 | 14篇 |
1997年 | 14篇 |
1996年 | 17篇 |
1995年 | 20篇 |
1994年 | 24篇 |
1993年 | 11篇 |
1992年 | 4篇 |
1991年 | 5篇 |
1990年 | 5篇 |
1989年 | 9篇 |
1988年 | 9篇 |
1987年 | 7篇 |
1986年 | 10篇 |
1985年 | 22篇 |
1984年 | 7篇 |
1983年 | 6篇 |
1982年 | 3篇 |
1981年 | 10篇 |
1980年 | 8篇 |
1979年 | 3篇 |
1978年 | 6篇 |
1977年 | 7篇 |
1976年 | 3篇 |
1974年 | 4篇 |
1972年 | 2篇 |
1971年 | 4篇 |
1970年 | 3篇 |
1969年 | 2篇 |
1967年 | 2篇 |
1966年 | 2篇 |
排序方式: 共有586条查询结果,搜索用时 0 毫秒
1.
2.
Ulrich Weber Christian WA Pfirrmann Rudolf O Kissling Juerg Hodler Marco Zanetti 《BMC musculoskeletal disorders》2007,8(1):20
Background
Ankylosing spondylitis is a chronic inflammatory rheumatic disorder which usually begins in early adulthood. The diagnosis is often delayed by many years. MR imaging has become the preferred imaging method for detection of early inflammation of the axial skeleton in ankylosing spondylitis. 相似文献3.
4.
5.
6.
7.
Retinal photoreceptor degeneration was induced by exposing albino rats to fluorescent illumination at elevated environmental temperatures. Fine carbon particles were injected intravenously or directly into the vitreous body or anterior chamber of the eye. The resulting pattern of invasion, migration, and egression of carbon-filled phagocytes in eyes with degenerated retinas was reconstructed from a time sequence series of light and electron microscopic tissue sections. Retinal debris, such as damaged photoreceptor outer segments and carbon particles, was most frequently removed by two populations of cells possessing phagocytic properties: mononuclear cells of vascular origin and pigment epithelial cells. After retinal damage, mononuclear cells appeared first in the vitreous body and later, in time sequence, progressively deeper in the inner plexiform layer and out to the bipolar nuclear layer, where they were seen within, or partially within, retinal capillaries. After intravenous carbon injection, however, marked phagocytes were not seen in the retina. Carbon-filled phagocytic cells were observed in the choroidal connective tissue and blood vessels after intravenous injection, but not after intravitreal injections of carbon. Therefore, retinal phagocytes did not appear to leave the eye through the choroidal circulation. Pigment epithelial cells proliferated by mitotic activity, occurred as single cells separated from Bruch's membrane, and were seen among the degenerated outer segments. After direct exposure to carbon particles, pigment cell phagosomes contained both carbon and lamellated discs of degenerated outer segments. Whether these cells exited from the eye through retinal capillaries or returned to Bruch's membrane to reestablish continuity in the pigment epithelium could not be determined. 相似文献
8.
Background
Genetic polymorphisms of the TCF7L2 gene are strongly associated with large increments in type 2 diabetes risk in different populations worldwide. In this study, we aimed to confirm the effect of the TCF7L2 polymorphism rs7903146 on diabetes risk in a Brazilian population and to assess the use of this genetic marker in improving diabetes risk prediction in the general population. 相似文献9.
10.
Previously we have described the properties of store-operated channel currents (SOCs) in freshly dispersed rabbit portal vein smooth muscle cells. In addition to Ca2+ store depletion these SOCs could also be activated by α-adrenoceptor stimulation and diacylglycerol (DAG) via a protein kinase C (PKC)-dependent mechanism. In the present study we have investigated the effect of β-adrenoceptor stimulation on SOCs in rabbit portal vein myocytes. With whole-cell recording the selective β-adrenoceptor agonist isoprenaline reduced the current evoked by cyclopiazonic acid (CPA, sarcoplasmic/endoplasmic reticulum ATPase inhibitor) by over 85%. With cell-attached patch recording, bath application of isoprenaline produced a pronounced inhibition of SOC activity evoked by either CPA or the acetoxymethyl ester form of BAPTA (BAPTA-AM). SOC activity evoked by CPA, the DAG analogue, 1-oleoyl-acetyl- sn -glycerol (OAG) or the phorbol ester, phorbol-12,13-dibutyrate (PDBu) was also markedly inhibited by the adenylate cyclase activator, forskolin, and the cell-permeable non-hydrolysable analogue of cyclic adenosine monophosphate (cAMP), 8-Br-cAMP. With inside-out patches, bath application of PDBu evoked channel currents with similar properties to SOCs which were inhibited by over 90% by a catalytic subunit of protein kinase A (PKA) and by 8-Br-cAMP. Moreover bath application of PKA inhibitors, H-89, KT5720 and an inhibitory peptide to quiescent cell-attached or inside-out patches, activated channel currents with similar properties to SOCs. These data suggest that in rabbit portal vein myocytes, stimulation of β-adrenoceptors inhibits SOC activity via a cAMP-dependent protein kinase signal transduction cascade. In addition it is concluded that constitutive PKA activity has a profound inhibitory effect on SOC activity in this vascular preparation. 相似文献