全文获取类型
收费全文 | 2324篇 |
免费 | 179篇 |
国内免费 | 22篇 |
专业分类
耳鼻咽喉 | 1篇 |
儿科学 | 176篇 |
妇产科学 | 36篇 |
基础医学 | 277篇 |
口腔科学 | 54篇 |
临床医学 | 219篇 |
内科学 | 565篇 |
皮肤病学 | 35篇 |
神经病学 | 153篇 |
特种医学 | 475篇 |
外科学 | 163篇 |
综合类 | 35篇 |
一般理论 | 1篇 |
预防医学 | 122篇 |
眼科学 | 17篇 |
药学 | 113篇 |
中国医学 | 3篇 |
肿瘤学 | 80篇 |
出版年
2021年 | 20篇 |
2020年 | 13篇 |
2019年 | 20篇 |
2018年 | 29篇 |
2017年 | 17篇 |
2016年 | 31篇 |
2015年 | 40篇 |
2014年 | 35篇 |
2013年 | 71篇 |
2012年 | 35篇 |
2011年 | 44篇 |
2010年 | 88篇 |
2009年 | 73篇 |
2008年 | 54篇 |
2007年 | 34篇 |
2006年 | 45篇 |
2005年 | 41篇 |
2004年 | 35篇 |
2003年 | 49篇 |
2002年 | 44篇 |
2001年 | 54篇 |
2000年 | 67篇 |
1999年 | 71篇 |
1998年 | 149篇 |
1997年 | 128篇 |
1996年 | 139篇 |
1995年 | 97篇 |
1994年 | 76篇 |
1993年 | 89篇 |
1992年 | 40篇 |
1991年 | 40篇 |
1990年 | 32篇 |
1989年 | 73篇 |
1988年 | 57篇 |
1987年 | 73篇 |
1986年 | 57篇 |
1985年 | 60篇 |
1984年 | 31篇 |
1983年 | 36篇 |
1982年 | 41篇 |
1981年 | 27篇 |
1980年 | 43篇 |
1979年 | 18篇 |
1978年 | 21篇 |
1977年 | 25篇 |
1976年 | 32篇 |
1975年 | 36篇 |
1973年 | 10篇 |
1971年 | 12篇 |
1969年 | 7篇 |
排序方式: 共有2525条查询结果,搜索用时 561 毫秒
1.
JA HYEON KU CHEOL KWAK SEUNG-JUNE OH EUNSIK LEE SANG EUN LEE JAE-SEUNG PAICK 《International journal of urology》2004,11(7):489-493
BACKGROUND: Our aims in the present study were to estimate the influences of pain and urinary symptoms on quality of life, and to determine which of these two variables has the most predictive power with respect to quality of life in young men with chronic prostatitis-like symptoms. METHODS: Chronic prostatitis-like symptoms were measured by the National Institutes of Health-Chronic Prostatitis Symptom Index. Of the 28,841 men aged 20 years who lived in the study community, 18,495 men (a response rate 64.1%) agreed to participate in the study. A total of 1057 men who complained of symptoms indicative of chronic prostatitis were included in the study. The influences of pain and urinary symptoms on quality of life were determined using logistic regression analysis. The receiver operating characteristic (ROC) curve was used to estimate the predictive ability of each of these variables with respect to quality of life. RESULTS: Results from multivariate analysis showed that both pain and urinary symptoms were associated with an increased likelihood of impaired quality of life, although pain contributed more to a reduced quality of life than urinary symptoms. Relative to men who experienced mild pain, men who experienced moderate pain had a 3.9-fold risk of poor quality of life (odds ratio [OR], 3.87; 95% confidence interval [CI], 2.86-5.23; P < 0.001) and those who experienced severe pain had a 15.7-fold risk of reduced quality of life (OR, 15.68; 95% CI, 6.59-37.35; P < 0.001). Moderate urinary symptoms were associated with a 1.4-fold risk of bother (OR, 1.41; 95% CI, 1.01-1.99; P < 0.001) and severe urinary symptoms were associated with 2.4-fold risk (OR, 2.39; 95% CI, 1.37-4.12; P < 0.001), relative to mild urinary symptoms. Comparison of the effects of pain and urinary symptoms showed that pain severity had the most predictive power for bother, quality of life, and quality-of-life impact. The areas under the ROC curves for bother, quality of life, and quality-of-life impact were 71.3%, 69.3% and 72.5%, respectively. CONCLUSION: Urinary symptoms and pain might be associated with an increased likelihood of impaired quality of life in young men with chronic prostatitis-like symptoms. In addition, our findings suggest that pain severity is the most influential variable for determining quality of life in this population. 相似文献
2.
E Miller A Nicoll S A Rousseau P J Sequeira M H Hambling R W Smithells H Holzel 《British medical journal (Clinical research ed.)》1987,294(6574):737-739
The incidence of congenital rubella was found to be 2.3 times higher in Asian than non-Asian births in England and Wales. This was attributed in part to higher susceptibility to rubella in Asian than non-Asian women, as shown by antenatal serological data from public health laboratories in Leeds, Luton, and Manchester. Examination of the ethnic origin of pregnant women requesting laboratory testing after contact with rubella or rash and of women with laboratory confirmed rubella in pregnancy also suggested that the disease was being underdiagnosed in pregnant Asian women. Failure to prevent congenital rubella by termination of infected pregnancies may therefore contribute to the increased incidence of the syndrome in Asians. Health education programmes about the dangers of rubella in pregnancy and of the need for vaccination can readily be promoted in the Asian community through existing ethnic organisations. Protection of other ethnic minorities likely to be at similar increased risk may require a vaccination programme aimed at national elimination of rubella. 相似文献
3.
4.
Benign intracranial hypertension and recombinant growth hormone therapy in Australia and New Zealand
PA Crock JD McKenzie AM Nicoll NJ Howard W Cutfield LK Shield G Byrne 《Acta paediatrica (Oslo, Norway : 1992)》1998,87(4):381-386
Benign intracranial hypertension (BIH) is reported in three children from Australia and one from New Zealand, who were being treated with recombinant human growth hormone (rhGH). Three males and one female, aged between 10.5 and 14.2 y, developed intracranial hypertension within 2 weeks to 3 months of starting treatment. A national database, OZGROW, has been prospectively collecting data on all 3332 children treated with rhGH in Australia and New Zealand from January 1986 to 1996. The incidence of BIH in children treated with growth hormone (GH) is small, 1.2 per 1000 cases overall, but appears to be greater with biochemical GHD (<10IUml -1 ), i.e. 6.5/1000 (3 in 465 cases), relative risk 18.4, 95% confidence interval 1.9-176.1, than in all other children on the database. The incidence in patients with Turner's syndrome was 2.3/1000 (1 in 428 cases). No cases in patients with partial GHD (10–20 IUml -1 ) or chronic renal failure were identified. Possible causative mechanisms are discussed. The authors'practice is now to start GH replacement at less than the usual recommended dose of 14IUm-2 week-1 in those children considered to be at high risk of developing BIH. Ophthalmological evaluation is recommended for children before and during the first few months following commencement of rhGH therapy and is mandatory in the event of peripheral or facial oedema, persistent headaches, vomiting or visual symptoms. The absence of papilledema does not exclude the diagnosis. 相似文献
5.
6.
7.
Long-term potentiation at single fiber inputs to hippocampal CA1 pyramidal cells. 总被引:4,自引:0,他引:4
下载免费PDF全文
![点击此处可从《Proceedings of the National Academy of Sciences of the United States of America》网站下载免费的PDF全文](/ch/ext_images/free.gif)
J T Isaac G O Hjelmstad R A Nicoll R C Malenka 《Proceedings of the National Academy of Sciences of the United States of America》1996,93(16):8710-8715
Despite extensive investigation, it remains unclear whether presynaptic and/or postsynaptic modifications are primarily responsible for the expression of long-term potentiation (LTP) in the CA1 region of the hippocampus. Here we address this issue by using techniques that maximize the likelihood of stimulating a single axon and thereby presumably a single synapse before and after the induction of LTP. Several basic properties of synaptic transmission were examined including the probability of neurotransmitter release (Pr), the quantal size (q), and the so-called potency, which is defined as the average size of the synaptic response when release of transmitter does occur. LTP was routinely associated with an increase in potency, whereas increases in Pr alone were not observed. LTP was also reliably induced when baseline Pr was high, indicating that synapses with high Pr can express LTP. These results suggest that the mechanism for the expression of LTP involves an increase in q and is difficult to explain by an increase in Pr alone. 相似文献
8.
9.
10.