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Joanne Fielding Nellie Georgiou-Karistianis Lynette Millist Michael Fahey Owen White 《Journal of the International Neuropsychological Society》2006,12(4):455-464
Trajectories of saccadic eye movements can be modulated by the presence of a competing visual distractor. It is proposed that the superior colliculus (SC) controls the initial deviation through competitive lateral interactions. Given the ramifications of connections between basal ganglia (BG) thalamo-cortical circuitry and the SC, it was anticipated that this modulation would be differentially effected in those with Huntington's disease, which in its early stages is primarily a disorder of the BG. Horizontal deviation was determined for exogenously driven and endogenously driven vertical saccades in the presence of peripheral distractors. For neurologically healthy participants, the initial trajectories of both saccade types curved away from distractor locations, as predicted. However, for HD participants exogenous saccades consistently deviated leftwards, irrespective of distractor location. Endogenous saccades also revealed anomalous horizontal deviation, with significant leftward deviation evident for saccades directed upward and significant rightward deviation for saccades directed downward. Further, both groups generated a comparable proportion of erroneous responses to distractor stimuli, but only neurologically healthy participants demonstrated a response time advantage for compatible target/distractor presentation. These results suggest anomalous regulation of distractor-related activity in HD. 相似文献
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Nadine C. Milos Yanling Ma Parag V. Varma Michael P. Bering Zarina Mohamed Linda M. Pilarski Yvette N. Frunchak 《Anatomy and embryology》1990,182(4):319-327
Summary A monoclonal antibody has been produced againstXenopus laevis galactoside-binding neural-creststage lectin. This antibody inhibits lectin-mediated hemagglutination. Using this antibody
in conjunction with immunohistochemical techniques, lectin deposition has been studied in embryos and tadpoles at different
stages of morphogenesis, from initial neural crest migration, up to the formation of a swimming tadpole. Lectin levels change
during development in different regions of the embryo and tadpole, decreasing in migratory cells, and increasing in sites
where cells become more adhesive to one another. The results suggest that galactoside-binding lectins may be an important
class of cellular adhesion molecules during these stages of development. 相似文献
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Manavotam Singh MD Nitin Malik MD Vijaywant Brar MD Patrick T. Bering MD Cyrus Hadadi MD Farooq H. Sheikh MD Phillip H. Lam MD 《Journal of cardiovascular electrophysiology》2021,32(3):862-866
Sustained ventricular tachycardia and ventricular fibrillation (VF) are life-threatening arrhythmias which remain highly prevalent in patients with advanced heart failure. These ventricular arrhythmias may impair the support provided by continuous-flow left ventricular assist devices (CF-LVADs) and lead to frequent hospitalizations, antiarrhythmic medication use, external defibrillations, and need for heart transplantation. We report a case in which a patient with a CF-LVAD and an implantable cardioverter defibrillator at end of life presented with asymptomatic low-flow alarms and was found to have VF of unknown duration. Unique in our case was the presence of apparent organized contractility and rhythmic opening of the mitral valve on echocardiogram despite VF on electrocardiogram. 相似文献