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Nicholas E. Johnson MD Janet Sowden BSc Nuran Dilek MS Katy Eichinger PT DPT NCS Joshua Burns PhD Michael P. Mcdermott PhD Michael E. Shy MD David N. Herrmann MBBCh 《Muscle & nerve》2015,51(4):485-488
Introduction: This study aims to assess the frequency, location, severity, duration, and fluctuation over time of muscle cramps in Charcot‐Marie‐Tooth disease (CMT). Methods: Inherited Neuropathies Consortium Contact Registry participants recorded the occurrence and characteristics of muscle cramps using an 11‐question survey administered 3 times over 8 weeks. Results: A total of 110 adult patients with CMT completed the survey. Weekly cramp frequency was 9.3 (SD 12.3), and 23% had daily muscle cramps. Twenty‐two percent reported a significant impact on quality of life. Over 8 weeks, the daily frequency and severity of muscle cramps did not change significantly. Conclusions: Patients with CMT have muscle cramps that vary little over an 8‐week period, and they may interfere with quality of life. These data may be useful in the planning of clinical trials of agents to treat adults with CMT‐associated muscle cramps. Muscle Nerve 51: 485–488, 2015 相似文献
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Chad Heatwole MD MS‐CI Rita Bode PhD Nicholas E. Johnson MD Jeanne Dekdebrun MS Nuran Dilek MS Katy Eichinger PT DPT NCS James E. Hilbert MS Eric Logigian MD Elizabeth Luebbe MS William Martens BA Michael P. Mcdermott PhD Shree Pandya PT DPT Araya Puwanant MD Nan Rothrock PhD Charles Thornton MD Barbara G. Vickrey MD MPH David Victorson PhD Richard T. Moxley MD III 《Muscle & nerve》2016,53(2):183-190
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