全文获取类型
收费全文 | 835篇 |
免费 | 49篇 |
国内免费 | 8篇 |
专业分类
耳鼻咽喉 | 1篇 |
儿科学 | 14篇 |
妇产科学 | 10篇 |
基础医学 | 82篇 |
口腔科学 | 5篇 |
临床医学 | 90篇 |
内科学 | 205篇 |
皮肤病学 | 35篇 |
神经病学 | 35篇 |
特种医学 | 51篇 |
外科学 | 76篇 |
综合类 | 10篇 |
预防医学 | 119篇 |
眼科学 | 4篇 |
药学 | 65篇 |
肿瘤学 | 90篇 |
出版年
2023年 | 12篇 |
2022年 | 18篇 |
2021年 | 19篇 |
2020年 | 10篇 |
2019年 | 18篇 |
2018年 | 14篇 |
2017年 | 19篇 |
2016年 | 28篇 |
2015年 | 22篇 |
2014年 | 28篇 |
2013年 | 38篇 |
2012年 | 68篇 |
2011年 | 70篇 |
2010年 | 37篇 |
2009年 | 45篇 |
2008年 | 41篇 |
2007年 | 49篇 |
2006年 | 57篇 |
2005年 | 50篇 |
2004年 | 55篇 |
2003年 | 23篇 |
2002年 | 38篇 |
2001年 | 17篇 |
2000年 | 10篇 |
1999年 | 10篇 |
1998年 | 17篇 |
1997年 | 4篇 |
1996年 | 7篇 |
1995年 | 7篇 |
1994年 | 9篇 |
1993年 | 8篇 |
1991年 | 1篇 |
1990年 | 1篇 |
1989年 | 3篇 |
1988年 | 10篇 |
1987年 | 4篇 |
1986年 | 4篇 |
1985年 | 4篇 |
1984年 | 3篇 |
1983年 | 1篇 |
1982年 | 2篇 |
1981年 | 1篇 |
1980年 | 3篇 |
1979年 | 1篇 |
1978年 | 1篇 |
1977年 | 3篇 |
1976年 | 1篇 |
1975年 | 1篇 |
排序方式: 共有892条查询结果,搜索用时 15 毫秒
1.
2.
3.
Oscillatory motion of the normal cervical spinal cord 总被引:2,自引:0,他引:2
4.
Mansouri D Mrad K Sassi S Driss-Fourati M Abbes I Koubaa-Mahjoub W Hechiche M Ben Romdhane K 《Annales de pathologie》2004,24(2):179-182
Pseudo-angiomatous hyperplasia of mammary stroma (PASH) is a histopathological entity which is a microscopic fortuitous finding in mammary biopsies performed for different reasons. It may be symptomatic and appears then as a palpable lump. The term pseudo-angiomatous emphasizes the characteristic aspect of the stroma simulating a vascular tumor. We report a case of PASH in a 71 year-old woman who presented a recurring breast mass with rapid swelling of the mammary gland (70 x 60 x 20 cm) treated by mastectomy. PASH must be distinguished from a well-differentiated angiosarcoma. It is ruled out by immunohistochemistry. 相似文献
5.
ALK Expression Defines a Distinct Group of T/Null Lymphomas (“ALK Lymphomas”) with a Wide Morphological Spectrum 下载免费PDF全文
Brunangelo Falini Barbara Bigerna Marco Fizzotti Karen Pulford Stefano A. Pileri Georges Delsol Antonino Carbone Marco Paulli Umberto Magrini Fabio Menestrina Roberto Giardini Silvana Pilotti Alessandra Mezzelani Barbara Ugolini Monia Billi Alessandra Pucciarini Roberta Pacini Pier-Giuseppe Pelicci Leonardo Flenghi 《The American journal of pathology》1998,153(3):875-886
The t(2;5)(p23;q35) translocation associated with CD30-positive anaplastic large cell lymphoma results in the production of a NPM-ALK chimeric protein, consisting of the N-terminal portion of the NPM protein joined to the entire cytoplasmic domain of the neural receptor tyrosine kinase ALK. The ALK gene products were identified in paraffin sections by using a new anti-ALK (cytoplasmic portion) monoclonal antibody (ALKc) that tends to react more strongly than a previously described ALK1 antibody with the nuclei of ALK-expressing tumor cells after microwave heating in 1 mmol/L ethylenediaminetetraacetic acid buffer, pH 8.0. The ALKc monoclonal antibody reacted selectively with 60% of anaplastic large cell lymphoma cases (60 of 100), which occurred mainly in the first three decades of life and consistently displayed a T/null phenotype. This group of ALK-positive tumors showed a wide morphological spectrum including cases with features of anaplastic large cell lymphoma “common” type (75%), “lymphohistiocytic” (10%), “small cell” (8.3%), “giant cell” (3.3%), and “Hodgkin’s like” (3.3%). CD30-positive large anaplastic cells expressing the ALK protein both in the cytoplasm and nucleus represented the dominant tumor population in the common, Hodgkin’s-like and giant cell types, but they were present at a smaller percentage (often with a perivascular distribution) also in cases with lymphohistiocytic and small cell features. In this study, the ALKc antibody also allowed us to identify small neoplastic cells (usually CD30 negative) with nucleus-restricted ALK positivity that were, by definition, more evident in the small cell variant but were also found in cases with lymphohistiocytic, common, and “Hodgkin’s-like” features. These findings, which have not been previously emphasized, strongly suggest that the neoplastic lesion (the NPM-ALK gene) must be present both in the large anaplastic and small tumor cells, and that ALK-positive lymphomas lie on a spectrum, their position being defined by the ratio of small to large neoplastic cells. Notably, about 15% of all ALK-positive lymphomas (usually of the common or giant cell variant) showed a cytoplasm-restricted ALK positivity, which suggests that the ALK gene may have fused with a partner(s) other than NPM. From a diagnostic point of view, detection of the ALK protein was useful in distinguishing anaplastic large cell lymphoma cases of lymphohistiocytic and small cell variants from reactive conditions and other peripheral T-cell lymphoma subtypes, as well as for detecting a small number of tumor cells in lymphohemopoietic tissues. In conclusion, ALK positivity appears to define a clinicopathological entity with a T/null phenotype (“ALK lymphomas”), but one that shows a wider spectrum of morphological patterns than has been appreciated in the past. 相似文献
6.
7.
Amel Rezgui Maissa Thabet Sahar Makki Jihed Anoun Imen Ben Hassine Monia Karmeni Fatma Ben Fredj Anis Mzabi Chedia Laouani 《Reumatologia》2021,59(2):111
Coexistence of spondyloarthritis (SpA) and Takayasu’s arteritis is not a common finding, but such cases have been discussed, particularly in the context of choice of therapy. Inhibition of inflammation by tumor necrosis factor inhibitors (TNFi) is a key aspect of the treatment of SpA and also positive effects of such treatment in concomitant large vessel vasculitis have been reported. However, TNFi is also associated with the possibility of initiating vasculitis.The present article based on a case study and the available literature is an attempt to discuss coexistence of these two diseases and the impact of treatment with biological drugs from the anti-TNF group in the course of SpA with Takayasu’s arteritis. 相似文献
8.
9.
10.